A5080775481- Psoriasis: Treatment and Pathogenesis
- Systemic Sclerosis and Related Diseases
- Cytokine Signaling Pathways and Interactions
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Autoimmune Bullous Skin Diseases
- Immunodeficiency and Autoimmune Disorders
- Melanoma and MAPK Pathways
- Liver Disease Diagnosis and Treatment
- Inflammatory Myopathies and Dermatomyositis
- Mast cells and histamine
- Liver Diseases and Immunity
- Dermatology and Skin Diseases
- Spondyloarthritis Studies and Treatments
- Asthma and respiratory diseases
- Hepatitis Viruses Studies and Epidemiology
- interferon and immune responses
- Topic Modeling
- Inflammatory Bowel Disease
- Hepatitis C virus research
- Multiple Sclerosis Research Studies
- NF-κB Signaling Pathways
- Immunotherapy and Immune Responses
- Autoimmune and Inflammatory Disorders Research
University of Thessaly
2015-2024
Centre for Research and Technology Hellas
2014-2024
Information Technologies Institute
2021
University Hospital of Larissa
2018-2019
Center for Rheumatology
2015-2017
Center for Research and Technology Thessaly
2012-2015
King's College London
2011-2013
King's College Hospital
2012-2013
King's College School
2011
King's College Hospital NHS Foundation Trust
2011
Breg cells, a regulatory cell subset that produces interleukin-10 (IL-10), play significant role in suppressing autoimmune responses and preventing autoimmunity. This study was undertaken to examine the number function of cells patients with systemic sclerosis (SSc), disease many autoantibodies.Forty-five SSc (12 early SSc, 33 established including 16 SSc-associated pulmonary fibrosis [PF]), 12 healthy control subjects, 10 rheumatoid arthritis (RA)-associated PF were studied. The phenotypes...
Abstract Objectives Psoriatic arthritis (PsA) and psoriasis are immune-mediated inflammatory diseases sharing common immunological mechanisms. Regulatory B cells (Breg cells) producing IL–10 (B10 cells), a critical anti-inflammatory B-cell subset, were found to be decreased in both PsA psoriasis. Apremilast, phosphodiesterase-4(PDE4) inhibitor, increases IL-10 therefore, we examined the effect of apremilast on Breg cells. Methods Fifty patients, including 20 with 30 psoriasis, included...
p38 mitogen activated protein kinase (p38 MAPK) signaling plays a major role in the modulation of immune-mediated inflammatory responses and therefore has been linked with several autoimmune diseases. The extent involvement MAPK pathogenesis blistering diseases started to emerge, but whether it pays critical is matter debate. activity studied great detail during loss keratinocyte cell-cell adhesions development pemphigus vulgaris (PV) foliaceus (PF). These are characterised by autoantibodies...
Primary biliary cirrhosis (PBC) is a cholestatic liver disease characterised by the autoimmune destruction of small intrahepatic bile ducts. The has an unpredictable clinical course, but may progress to fibrosis and cirrhosis. Although medical treatment with urseodeoxycholic acid largely successful, some patients failure requiring transplantation. PBC presence specific anti-mitochondrial (AMA) antibodies, which are pathognomonic for development. demonstrates overwhelming female preponderance...
Abstract Psoriasis is an inflammation of the skin mediated via IL-23/Thl17/IL-17 pathway. We have previously demonstrated that anthocyanin delphinidin diminishes in vitro IL-17 and IFN-γ production peripheral monocytes isolated by psoriasis patients (PBMCs). The degradation product gallic acid (GA). This phenolic compound found fruits, red wine, or green tea exerts pleiotropic antioxidant, anticarcinogenic, antimicrobial, anti-inflammatory properties. Previous research has inhibitory effect...
Limited data from clinical trials in multiple sclerosis (MS) reported that minocycline, a widely used antibiotic belonging to the family of tetracyclines (TCs), exerts beneficial short-lived effect A similar anti-inflammatory minocycline attributed deviation Th1 Th2 immune response has been experimental models MS. Whether such an immunomodulatory mechanism is operated human disease remains largely unknown.To assess vitro tetracyclines, and particular doxycycline, naïve treated patients with...
Cannabidiol (CBD), a substance that belongs to the phytocannabinoids, appears exert antioxidant, neuroprotective, antipsychotic, anticonvulsant, and anticancer properties. Recent evidence supports immunoregulatory effect of CBD on autoimmune and/or inflammatory disease. Psoriasis is chronic skin The main immune cell population involved in pathogenesis disease interleukin- (IL-) 17-producing T helper (Th) 17 subset. Other subpopulations, such as interferon-γ (IFNγ) -producing Th1 cytotoxic...