A5000092638- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Drug-Induced Hepatotoxicity and Protection
- Organ Transplantation Techniques and Outcomes
- Cardiovascular Disease and Adiposity
- Alcohol Consumption and Health Effects
- Liver Diseases and Immunity
- Immune Response and Inflammation
- Pancreatitis Pathology and Treatment
- Diabetes and associated disorders
- Inflammatory Biomarkers in Disease Prognosis
- Sepsis Diagnosis and Treatment
- Clinical Nutrition and Gastroenterology
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Immune Cell Function and Interaction
- Metabolomics and Mass Spectrometry Studies
- Inflammation biomarkers and pathways
- Renal function and acid-base balance
- Intensive Care Unit Cognitive Disorders
- Nutrition and Health in Aging
- Adrenal Hormones and Disorders
- Acute Lymphoblastic Leukemia research
- Enhanced Recovery After Surgery
- Macrophage Migration Inhibitory Factor
Queen Mary University of London
2023
Newcastle upon Tyne Hospitals NHS Foundation Trust
2023
Freeman Hospital
2023
Peninsula Health
2023
University of Plymouth
2023
St Mary's Hospital
2019
Imperial College London
2019
Chelsea and Westminster Hospital
2019
King's College London
2010-2017
King's College Hospital
2008-2017
Predicting survival in decompensated cirrhosis (DC) is important decision making for liver transplantation and resource allocation. We investigated whether high-resolution metabolic profiling can determine a phenotype associated with 90-day survival.Two hundred forty-eight subjects underwent plasma metabotyping by (1)H nuclear magnetic resonance (NMR) spectroscopy reversed-phase ultra-performance liquid chromatography coupled to time-of-flight mass spectrometry (UPLC-TOF-MS; DC:...
Summary Background Patients with cirrhosis are susceptible to sepsis, pre‐disposing the development of encephalopathy, bleeding and organ dysfunction associated high mortality. Aim To characterise circulating neutrophil function in a cirrhotic cohort as determinant 90‐day 1‐year Methods Sixty‐two patients [49 stable (Child–Pugh A/B/C = 24%/39%/37%); 13 acute‐on‐chronic liver failure] were prospectively studied compared 11 healthy controls. Neutrophil was evaluated at baseline repeated...
Background & AimsPatients with acute liver failure (ALF) have defects in innate immune responses to microbes (immune paresis) and are susceptible sepsis. Cytotoxic T-lymphocyte−associated protein 4 (CTLA4), which interacts the membrane receptor B7 (also called CD80 CD86), is a negative regulator of T-cell activation. We collected T cells from patients ALF investigated whether inhibitory signals down-regulate adaptive ALF.MethodsWe peripheral blood mononuclear controls September 2013 through...
Summary Background Atherosclerotic cardiovascular disease is a key cause of morbidity in non‐alcoholic fatty liver (NAFLD) but appropriate means to predict major acute events (MACE) are lacking. Aim To design bespoke risk score NAFLD. Methods A retrospective derivation (2008‐2016, 356 patients) and prospective validation (2016‐ 2017, 111 NAFLD cohort study was performed. Clinical biochemical data were recorded at enrolment mean platelet volume (MPV), Qrisk2 Framingham scores one year prior...
Patients with alcohol-related liver disease (ALD) have antibodies directed to alcohol dehydrogenase (ADH), anti-ADH titers being associated severity and active consumption. ADH-specific T-cell responses not been characterized. We aimed define cellular immune their association consumption severity. Using cultures of peripheral blood mononuclear cells (PBMCs) from 25 patients cirrhosis (ARC; 12 were actively drinking or abstinent for <6 months, 13 >6 months) hepatic (HMCs) 14 ARC who...
Acute variceal haemorrhage (AVH) is associated with significant mortality.To determine outcome and factors hospital mortality (HM) in patients AVH admitted to intensive care unit (ICU) compare outcomes of requiring transfer a tertiary ICU (transfer group, TG) local in-patient group (LG).A retrospective study all adult (N = 177) from 2000-2008 was performed.Median age 48 years (16-80). Male represented 58%. Median MELD score 16 (6-39), SOFA 8 (6-11). HM higher who had severe liver disease or...
Primary biliary cirrhosis (PBC) is a cholestatic liver disease characterised by the autoimmune destruction of small intrahepatic bile ducts. The has an unpredictable clinical course, but may progress to fibrosis and cirrhosis. Although medical treatment with urseodeoxycholic acid largely successful, some patients failure requiring transplantation. PBC presence specific anti-mitochondrial (AMA) antibodies, which are pathognomonic for development. demonstrates overwhelming female preponderance...
Patients with alcohol-related cirrhosis (ALD) are prone to infection. Circulating neutrophils in ALD dysfunctional and predict development of sepsis, organ dysfunction, survival. Neutrophil granules important effector organelles containing a toxic array microbicidal proteins, whose controlled release is required kill microorganisms while minimizing inflammation damage host tissue. We investigated the role these granular responses contributing immune disarray ALD. content mobilization were...
•This study identified significant variation in the management of NAFLD UK.•Non-invasive fibrosis assessment was only performed 27.9% patients with suspected NAFLD.•Greater emphasis on associated cardiometabolic risk factors is warranted individuals NAFLD.•Fibrosis evaluation and were more likely within hospitals a multidisciplinary service.•Further work needed to align guideline recommendations real-world practice care. Background & AimsNon-alcoholic fatty liver disease (NAFLD)...
<h3>Introduction</h3> There is a marked propensity for patients with acute liver failure (ALF) and cirrhosis to develop sepsis inflammation which may hasten the development of hepatic encephalopathy (HE) cerebral oedema. Neutrophil dysfunction an important biomarker poor prognosis in neutrophil TLR9 expression upregulates ammonia exposure. paucity understanding regarding relationship between HE, moreover there lack predictive/prognostic biomarkers that differentiate ALF will go on HE. The...