A5032059550- Axon Guidance and Neuronal Signaling
- Hair Growth and Disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Genetics and Neurodevelopmental Disorders
- Dermatology and Skin Diseases
- Neurogenesis and neuroplasticity mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Single-cell and spatial transcriptomics
- PARP inhibition in cancer therapy
- Skin and Cellular Biology Research
- Insect and Arachnid Ecology and Behavior
- Integrated Circuits and Semiconductor Failure Analysis
- Plant and animal studies
- Zebrafish Biomedical Research Applications
- Autism Spectrum Disorder Research
- Animal and Plant Science Education
- Neurobiology and Insect Physiology Research
- Nerve injury and regeneration
- Genomic variations and chromosomal abnormalities
- melanin and skin pigmentation
- Low-power high-performance VLSI design
- CRISPR and Genetic Engineering
University of Washington
2024
Vollum Institute
2021-2023
Oregon Health & Science University
2015-2023
California State University, Fresno
2015-2018
Animal evolution is influenced by the emergence of new cell types, yet our understanding this process remains elusive. This prompts need for a broader exploration across diverse research organisms, facilitated recent breakthroughs, such as gene editing tools and single-cell genomics. Essential to type accurate identification homologous cells. We delve into significance considering developmental ontogeny potential pitfalls when drawing conclusions about homology. Additionally, we highlight...
PARP6, a member of family enzymes (17 in humans) known as poly-ADP-ribose polymerases (PARPs), is neuronally enriched PARP. While previous studies from our group show that Parp6 regulator dendrite morphogenesis rat hippocampal neurons, its function the nervous system vivo poorly understood. Here, we describe generation loss-of-function mouse model for examining during neurodevelopment vivo. Using CRISPR-Cas9 mutagenesis, generated line expressed truncated variant (Parp6TR) place Parp6WT....
Abstract The mammalian somatosensory system is comprised of multiple neuronal populations that form specialized, highly organized sensory endings in the skin. organization essential to their functions, yet mechanisms which regulate this remain unclear. Using a combination genetic and molecular labeling approaches, we examined development mouse hair follicle-innervating low-threshold mechanoreceptors (LTMRs) explored competition for innervation targets as mechanism involved patterning...
Peripheral somatosensory neurons innervate the skin and sense environment. Whereas many studies focus on initial axon outgrowth pathfinding, how signaling pathways contribute to maintenance of established arbors terminals within is largely unknown. This question particularly relevant types neuropathies that affect mature neuronal arbors. We show a receptor tyrosine kinase (RTK), c-Kit, contributes maintenance, but not development, cutaneous axons in larval zebrafish before sex determination....
When cockroaches are trained to a visual-olfactory cue pairing using the antennal projection response (APR), they can form different memories for location of visual cue. A series experiments, each examining memory spatial cue, were performed restrained cockroaches. The first group experiments involved training associate (CS-green LED) with an odor (US) in presence or absence second reference (white LED). These revealed that have at least two forms memory. First, it was found during learning,...
Cutaneous innervation is an essential component of the mammalian sensory nervous system. During development, genetically and morphologically diverse subtypes neurons use distinct molecular pathways to innervate end organs or form free nerve endings in glabrous hairy skin. Peripheral can be damaged by acute injury degenerate due chronic conditions including diabetes chemotherapy, leading peripheral neuropathy. The analysis skin cutaneous applied many research endeavors, from developmental...
Abstract The mammalian somatosensory system is comprised of multiple neuronal populations that form specialized, highly organized sensory endings in the skin. organization essential to their functions, yet mechanisms which regulate this remain unclear. Using a combination genetic and molecular labeling approaches, we examined development mouse hair follicle-innervating low-threshold mechanoreceptors (LTMRs) explored competition for innervation targets as mechanism involved patterning...
ABSTRACT Peripheral somatosensory neurons innervate the skin and sense environment. Loss of innervation, often caused by “dying back” distal axons, is a common side effect drug-induced peripheral neuropathies (DIPNs) results in pain sensory dysfunction. Targeted cancer therapies frequently employ multi-kinase inhibitor (MKI) drugs that each block multiple receptor tyrosine kinases. Many MKIs produce DIPNs but molecular targets cellular mechanisms underlying these are unknown. We performed...