A5084592481- Systemic Lupus Erythematosus Research
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Genetic factors in colorectal cancer
- Low-power high-performance VLSI design
- DNA Repair Mechanisms
- PARP inhibition in cancer therapy
- Integrated Circuits and Semiconductor Failure Analysis
- T-cell and B-cell Immunology
University of Arizona Cancer Center
2021-2022
University of Arizona
2021-2022
Oregon Health & Science University
2021
PARP6, a member of family enzymes (17 in humans) known as poly-ADP-ribose polymerases (PARPs), is neuronally enriched PARP. While previous studies from our group show that Parp6 regulator dendrite morphogenesis rat hippocampal neurons, its function the nervous system vivo poorly understood. Here, we describe generation loss-of-function mouse model for examining during neurodevelopment vivo. Using CRISPR-Cas9 mutagenesis, generated line expressed truncated variant (Parp6TR) place Parp6WT....
Systemic lupus erythematosus is a chronic disease characterized by autoantibodies, renal and cutaneous disease, immune complex formation. Emerging evidence suggests that aberrant DNA repair an underlying mechanism of development. We previously showed the POLBY265C/C mutation, which results in development repertoire, leads to lupus-like mice. To address whether hematopoietic compartment sufficient for development, we transplanted bone marrow cells from POLB+/+ into wild-type congenic Only...