A5004486348- Circadian rhythm and melatonin
- Mitochondrial Function and Pathology
- Inflammasome and immune disorders
- Nutrition and Health in Aging
- Dietary Effects on Health
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
- Sperm and Testicular Function
- Circular RNAs in diseases
- Muscle Physiology and Disorders
- Genetics, Aging, and Longevity in Model Organisms
- Body Composition Measurement Techniques
- Autophagy in Disease and Therapy
- Parkinson's Disease Mechanisms and Treatments
- Birth, Development, and Health
- Liver Disease and Transplantation
- Extracellular vesicles in disease
- Health, psychology, and well-being
- Tryptophan and brain disorders
- Hereditary Neurological Disorders
- Retinoids in leukemia and cellular processes
- Hydrogen's biological and therapeutic effects
- Exercise and Physiological Responses
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Psychological and Temporal Perspectives Research
The University of Texas Health Science Center at San Antonio
2022-2025
Parque Tecnológico de la Salud
2017-2022
Universidad de Granada
2017-2022
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable
2022
Instituto de Investigación Biosanitaria de Granada
2022
The NLRP3 inflammasome is involved in the innate immune response during inflammation. Moreover, melatonin blunts NF-κB/NLRP3 connection sepsis. Thus, we compared roles of and/or treatment septic wild-type and NLRP3-/- mice. Mouse myocardial tissue was used for this purpose. nuclear turnover NF-κB enhanced sepsis, with an increase TNFα, iNOS, pro-IL-1β. lack mice significantly reduced that blunted IL-1β maturation due to caspase-1. Clock Bmal1 did not change both mouse strains, enhancing...
Although circulating microRNAs (miRNAs) can modulate gene expression and affect immune system response, little is known about their participation in age‐associated frailty syndrome sarcopenia. The aim of this study was to determine miRNAs as possible biomarkers age correlation with oxidative inflammatory state human blood. Three inflammation‐related (miR‐21, miR‐146a, miR‐223) one miRNA related the control melatonin synthesis (miR‐483) were analyzed. Twenty‐two healthy adults, 34 aged...
Abstract To investigate the role of NLRP3 inflammasome in muscular aging, we evaluated here morphological and functional markers sarcopenia NLRP3-knockout mice, as well beneficial effect melatonin supplementation. The gastrocnemius muscles young (3 months), early-aged (12 old-aged (24 months) female mice were examined. Moreover, locomotor activity apoptosis assessed. results revealed early at age 12 months, including reduction lactate, ratio muscle weight to body weight, fibers number,...
Previous data showed that the administration of high doses melatonin improved circadian system in athletes. Here, we investigated same experimental paradigm whether antioxidant properties has also beneficial effects against exercise-induced oxidative stress and muscle damage Twenty-four athletes were treated with 100 mg·day-1 or placebo 30 min before bedtime during 4 weeks a randomized double-blind scheme. Exercise intensity was higher study starting it. Blood samples collected after...
Aging is a major risk for cardiovascular diseases (CVD). Age-related disorders include oxidative stress, mitochondria dysfunction, and exacerbation of the NF-κB/NLRP3 innate immune response pathways. Some molecular mechanisms underlying these processes, however, remain unclear. This study tested hypothesis that NLRP3 inflammasome plays role in cardiac aging melatonin able to counteract its effects. With aim investigating impact actions target aged myocardium, we analyzed expression proteins...
To gain insight into the mechanism of sarcopenia and protective effect melatonin, gastrocnemius muscles young (3-4 months), early-aged (12 old-aged (24 months) wild-type C57BL/6J female mice were examined by magnetic resonance microscopy. Locomotor activity, lactate production, nuclear apoptosis also assessed. The results support early onset at 12 months age, with reduction muscle fiber number, weight/body weight ratio, lactate, locomotor activity. Lipid droplet infiltration autophagosomes...
MPTP-mouse model constitutes a well-known of neuroinflammation and mitochondrial failure occurring in Parkinson's disease (PD). Although it has been extensively reported that nitric oxide (NO●) plays key role the pathogenesis PD, relative roles synthase isoforms iNOS nNOS nigrostriatal pathway remains, however, unclear. Here, participation iNOS/nNOS dysfunction was analyzed deficient mice. Our results showed MPTP increased activity substantia nigra striatum, whereas sharply reduced complex I...
Charcot-Marie-Tooth neuropathy (CMT) is a motor and sensory comprising heterogeneous group of inherited diseases. The CMT1A phenotype predominant in the 70% CMT patients, with nerve conduction velocity reduction hypertrophic demyelination. These patients have elevated oxidative stress chronic inflammation. Currently, there no effective cure for CMT; herein, we investigated whether melatonin treatment may reduce inflammatory damage patients. Three aged 8-10 years, were treated (60 mg at 21:00...
Muscular aging is a complex process and underlying physiological mechanisms are not fully clear. In recent years, the participation of NF-kB pathway NLRP3 inflammasome in chronic inflammation that accompanies skeletal muscle’s has been confirmed. microRNAs (miRs) form part gene regulatory machinery, they control numerous biological processes including inflammatory pathways. this work, we studied expression four miRs; three them considered as inflammatory-related miRs (miR-21, miR-146a,...
Age and age-dependent inflammation are two main risk factors for cardiovascular diseases. Aging can also affect clock gene-related impairments such as chronodisruption has been linked to a decline in melatonin synthesis aggravation of the NF-κB/NLRP3 innate immune response known inflammaging. The molecular drivers these mechanisms remain unknown. This study investigated impact aging NLRP3 expression on cardiac circadian system, actions potential therapy restore daily rhythms by mitigating We...
To investigate the role of NLRP3 inflammasome in cardiac aging, we evaluate here morphological and ultrastructural age-related changes muscles fibers wild-type NLRP3-knockout mice, as well studying beneficial effect melatonin therapy. The results clarified beginning sarcopenia at age 12 months, with hypertrophy myocytes, increased expression β-MHC, appearance small necrotic fibers, decline cadiomyocyte number, destruction mitochondrial cristae, small-sized residual bodies, apoptotic nuclei...
Although mitochondria dysfunction is related to multiple diseases, no in vivo studies are available on mitochondrial respiration animal parkinsonian models. Our aim analyze respiration, which reflects changes bioenergetics more precisely than vitro preparations. These experiments can be carried out zebrafish embryos, were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) from 24 72 hours postfertilization (hpf). A reduction electron transfer system capacity, ATP turnover, and...
The role of retinoid acid receptor-related orphan receptor alpha (RORα) on male reproductive functions during aging is unclear.Here, we analyze the morphological changes in testis both young and aged RORαdeficient mice, with without melatonin supplementation.Young mutants showed vacuolation, degeneration pyknosis spermatogenic epithelium Sertoli cells.Aged atrophy seminiferous tubules absence mitotic cells.Absence sperms many tubules, loss acrosomal cap, vacuolation hypertrophy cells were...