A5064048303- Circadian rhythm and melatonin
- Mitochondrial Function and Pathology
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Zebrafish Biomedical Research Applications
- Spaceflight effects on biology
- Photoreceptor and optogenetics research
- Chemical Reactions and Isotopes
- Redox biology and oxidative stress
- Birth, Development, and Health
- Inflammasome and immune disorders
- Coenzyme Q10 studies and effects
- Skin Protection and Aging
- Electromagnetic Fields and Biological Effects
- Autophagy in Disease and Therapy
- Allergic Rhinitis and Sensitization
- Genomics, phytochemicals, and oxidative stress
- Sleep and Wakefulness Research
- Dietary Effects on Health
- Hydrogen's biological and therapeutic effects
- Advanced Glycation End Products research
- S100 Proteins and Annexins
- Light effects on plants
- Tryptophan and brain disorders
Universidad de Granada
2019-2024
Instituto de Investigación Biosanitaria de Granada
2023-2024
Aarhus University
2024
Parque Tecnológico de la Salud
2021-2023
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable
2023
Head and neck cancer is the sixth leading by incidence worldwide. Unfortunately, drug resistance relapse are principal limitations of clinical oncology for many patients, failure conventional treatments an extremely demoralizing experience. It therefore crucial to find new therapeutic targets drugs enhance cytotoxic effects without potentiating or offsetting adverse effects. Melatonin has oncostatic effects, although mechanisms involved doses required remain unclear. The purpose this study...
The oncostatic effects of melatonin correlate with increased reactive oxygen species (ROS) levels, but how induces this ROS generation is unknown. In the present study, we aimed to elucidate two seemingly opposing actions regarding its relationship free radicals. We analyzed on head and neck squamous cell carcinoma lines (Cal-27 SCC-9), which were treated 0.5 or 1 mM melatonin. further examined potential induce apoptosis in Cal-27 xenograft mice. Here report that mediates cancer by driving...
Antioxidant defenses in biological systems ensure redox homeostasis, regulating baseline levels of reactive oxygen and nitrogen species (ROS RNS). Oxidative stress (OS), characterized by a lack antioxidant or an elevation ROS RNS, may cause modification biomolecules, being primarily absorbed proteins. As result both genome environment interactions, proteomics provides complete information about cell’s proteome, which changes continuously. Besides measuring protein expression levels, can also...
Metabolic reprogramming, which is characteristic of cancer cells that rapidly adapt to the hypoxic microenvironment and crucial for tumor growth metastasis, recognized as one major mechanisms underlying therapeutic resistance. Mitochondria, are directly involved in metabolic used design novel mitochondria-targeted anticancer agents. Despite being targeted by melatonin, functional role mitochondria melatonin’s oncostatic activity remains unclear. In this study, we aim investigate melatonin...
Head and neck squamous cell carcinoma present a high mortality rate. Melatonin has been shown to have oncostatic effects in different types of cancers. However, inconsistent results reported for vivo applications. Consequently, an alternative administration route is needed improve bioavailability establish the optimal dosage melatonin cancer treatment. On other hand, use patient-derived tumor models transformed field drug research because they reflect heterogeneity patient tissues. In study,...
Muscular aging is a complex process and underlying physiological mechanisms are not fully clear. In recent years, the participation of NF-kB pathway NLRP3 inflammasome in chronic inflammation that accompanies skeletal muscle’s has been confirmed. microRNAs (miRs) form part gene regulatory machinery, they control numerous biological processes including inflammatory pathways. this work, we studied expression four miRs; three them considered as inflammatory-related miRs (miR-21, miR-146a,...
Beyond sleep/wake, clock genes regulate the daily rhythms of melatonin production, motor activity, innate immunity, and mitochondrial dynamics, among others. All these are affected in Parkinson's disease (PD), suggesting that chronodisruption may be an early stage disease. The aim this study was to evaluate connection between PD, whether administration reestablished normal function. Parkinsonism induced with 600 μM MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) 24-120 h post...
The circadian clock is a regulatory system, with periodicity of approximately 24 h, which generates rhythmic changes in many physiological processes, including mitochondrial activity. Increasing evidence links chronodisruption aberrant functionality gene expression, resulting multiple diseases such as cancer. Melatonin, whose production and secretion oscillates according to the light-dark cycle, principal regulator expression. In addition, oncostatic effects melatonin correlate an increase...
Abstract Head and neck squamous cell carcinoma present a high mortality rate. Melatonin has been shown to have oncostatic effects in different types of cancers. However, inconsistent results reported for vivo applications. Consequently, an alternative administration route is needed improve bioavailability establish the optimal dosage melatonin cancer treatment. On other hand, use patient-derived tumor models transformed field drug research because they reflect heterogeneity patient tissues....