A5085108977- Cognitive Abilities and Testing
- Birth, Development, and Health
- Health disparities and outcomes
- Parkinson's Disease Mechanisms and Treatments
- Insurance, Mortality, Demography, Risk Management
- Early Childhood Education and Development
- Genetic Associations and Epidemiology
- Health, Environment, Cognitive Aging
- Aging and Gerontology Research
- Genetics and Neurodevelopmental Disorders
- Neurological disorders and treatments
- Stress Responses and Cortisol
- Genetic Neurodegenerative Diseases
- Musculoskeletal synovial abnormalities and treatments
- Obesity, Physical Activity, Diet
- Forecasting Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- Orthopedic Infections and Treatments
- Advanced Statistical Modeling Techniques
- Child Welfare and Adoption
- Education, Achievement, and Giftedness
- Amyotrophic Lateral Sclerosis Research
- Psychometric Methodologies and Testing
- Statistical Methods and Bayesian Inference
- Psychological Well-being and Life Satisfaction
TetraLogic Pharmaceuticals (United States)
2023-2025
Oregon Health & Science University
2021-2024
Vanderbilt University
2017-2023
Peabody
2019
This paper introduces an extension of cluster mean centering (also called group centering) for multilevel models, which we call "double decomposition (DD)." method separates between-level variance, as in centering, but also decomposes within-level variance the same variable. process retains benefits allows context variables derived from lower level variables, other than mean, to be incorporated into model. A brief simulation study is presented, demonstrating potential advantage (or even...
Studies have reported that the age-adjusted incidence of cognitive impairment and dementia may decreased over past two decades. Aging is predominant risk factor for Alzheimer's disease related dementias neurocognitive decline. However, aging cannot explain changes in overall dementia. The objective this position paper was to describe potential cohort period effects decline Cohort long been demographic literature, but starting early 1980s, researchers began reporting trends function. At same...
Spinocerebellar ataxias (SCA) are rare inherited neurodegenerative disorders characterized by a progressive impairment of gait, balance, limb coordination, and speech. There is currently no composite scale that includes multiple aspects the SCA experience to assess disease progression treatment effects. Applying method partial least squares (PLS) regression, we developed Ataxia Composite Scale (SCACOMS) from two natural history datasets (NCT01060371, NCT02440763). PLS regression selected...
To contribute to our understanding of cohort differences and the Flynn effect in cognitive decline among older Americans, this study aims compare rates between two birth cohorts within a Americans examine importance medical demographic confounders. Analyses used data from National Health Aging Trends Study (2011-2019), which recruited 2011 again 2015 who were then followed for 5 years. We employed mixed-effect models linear quadratic main interaction effects year while adjusting covariates...
Abstract Objectives This paper models cognitive aging, across mid and late life, estimates birth cohort sex differences in both initial levels aging trajectories over time a sample with multiple cohorts wide span of ages. Methods The data used this study came from the first 9 waves English Longitudinal Study Ageing, spanning 2002–2019. There were n = 76,014 observations (proportion male 45%). Dependent measures verbal fluency, immediate recall, delayed orientation. Data modeled using...
Grip strength is a popular and valuable measure in studies of physical functional capabilities old age. The influence historical trends differential period-specific exposures can complicate the interpretation biomarkers aging health requires careful analysis aging, birth cohort, period effects. This study evaluates effects period, cohort on grip population adults older adults.
The Flynn effect refers to increases over time in measured (particularly fluid) intelligence of approximately 3 IQ points per decade. We define the at family level, using longitudinal data and two new family-level cohort definitions. Multilevel growth curve analyses National Longitudinal Survey Youth 1979 showed that children families with later-born mothers had higher average PIAT math scores, lower reading comprehension scores growth, young middle childhood. Children where first child was...
This work examines how composite scores (CS) of re-weighted combinations the MDS-UPDRS PART II items can better detect meaningful changes and increase success for efficacious disease-modifying treatments.
Examine composite scores (CS) of re-weighted combinations the MDS-UPDRS items as a more sensitive measure meaningful changes in motor progression.
Previous work using U.S. data has identified generational shifts, reflected in inter-cohort changes, the incidence and prevalence of diseases older ages. This study extends previous findings to England by examining similar results memory complaints, heart conditions, stroke, diabetes, lung disease, cancer from English Longitudinal Study Ageing (ELSA). We fit Cox proportional hazard models first eight waves (2002-2016) ELSA sample (
This article describes calcific tendonitis within the fibular collateral ligament, presumably from hydroxyapatite deposition, a rare cause of acute, severe lateral knee pain. Imaging findings confirmed calcifications in an intact but thickened ligament with adjacent soft-tissue reaction, consistent tendonitis. Magnetic resonance imaging can appear aggressive, and therefore often be mistaken for other abnormalities; specifically, presentation following twisting injury that requires avulsion...
Objective: Using a large longitudinal sample of adults from the Midlife in United States (MIDUS) study, present study extended recently developed hierarchical model to determine how best longitudinally cumulative stress, and whether rate change stress or level over time are stronger predictors health outcomes. Method: We used factor analysis estimate stress-factor score then, operationalize accumulation we examined four approaches aggregating information about repeated exposures multiple...
Abstract Disease modifying therapies (DMTs) are hypothesized to be most beneficial in early disease when progression is slow and mean changes will small. Therefore, even highly effective yield small absolute differences whose clinical relevance may hard interpret. Time component tests (TCTs) translate between treatments change – the vertical distance longitudinal trajectories, into an intuitively understood metric of time saved horizontal trajectories. This corresponds maintenance...