A5006122717- Immunotherapy and Immune Responses
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- CAR-T cell therapy research
- Neuroinflammation and Neurodegeneration Mechanisms
- Virus-based gene therapy research
- Computational Drug Discovery Methods
- vaccines and immunoinformatics approaches
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- 3D Printing in Biomedical Research
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Additive Manufacturing and 3D Printing Technologies
- Cholinesterase and Neurodegenerative Diseases
- Cell Adhesion Molecules Research
- Cutaneous Melanoma Detection and Management
- Dermatology and Skin Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Dermatological and Skeletal Disorders
- Systemic Lupus Erythematosus Research
- Biochemical Acid Research Studies
- Atherosclerosis and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
Vienna Biocenter
2014-2025
AFFiRiS (Austria)
2010-2021
Klinik Hirslanden
2010
University of Vienna
1995-2009
Howard Hughes Medical Institute
2008
Austrian Academy of Sciences
2003-2006
Medical University of Graz
2006
Medical University of Vienna
1995-2006
Universitätsmedizin Greifswald
2006
Vienna General Hospital
2006
The recent identification of toll-like receptors (TLRs) and respective ligands allows the evaluation novel dendritic cell (DC) -activating strategies. Stimulation TLR9 directly activates human plasmacytoid DCs (PDCs) indirectly induces potent innate immune responses in preclinical tumor models. We performed an open-label, multicenter, single-arm, phase II pilot trial with a TLR9-stimulating oligodeoxynucleotide melanoma patients.Patients unresectable stage IIIb/c or IV received 6 mg...
Natural killer (NK) cell tolerance mechanisms are incompletely understood. One possibility is that they possess self-specific activation receptors result in hyporesponsiveness unless modulated by self-major histocompatability complex (MHC)-specific inhibitory receptors. As putative have not been well characterized, we studied a transgenic C57BL/6 mouse ubiquitously expresses m157 (m157-Tg), which the murine cytomegalovirus (MCMV)-encoded ligand for Ly49H NK receptor. The mice were more...
Multiple system atrophy (MSA) is a neurodegenerative disease characterized by parkinsonism, ataxia and dysautonomia. Histopathologically, the hallmark of MSA abnormal accumulation alpha-synuclein (α-syn) within oligodendroglial cells, leading to neuroinflammation, demyelination neuronal death. Currently, there no disease-modifying treatment for MSA. In this sense, we have previously shown that next-generation active vaccination technology with short peptides, AFFITOPEs®, was effective in two...
Background Low Density Lipoprotein (LDL) hypercholesterolemia, and its associated cardiovascular diseases, are some of the leading causes death worldwide. The ability proprotein convertase subtilisin/kexin 9 (PCSK9) to modulate circulating LDL cholesterol (LDLc) concentrations made it a very attractive target for LDLc management. To date, most advanced approaches PCSK9 inhibition monoclonal antibody (mAb) therapies. Although shown lower significantly, mAbs face functional limitations because...
Abstract Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disease with limited symptomatic treatment options. Aggregation of α‐synuclein in oligodendrocytes believed to be central mechanism the process. PD01A PD03A are 2 novel therapeutic vaccine candidates containing short peptides as antigenic moieties that designed induce sustained antibody response, specifically targeting pathogenic assemblies α‐synuclein. The objectives current study were evaluate primarily safety...
Self-assembly of solid organs from single cells would greatly expand applicability regenerative medicine.Stem/progenitor can self-organize into micro-sized organ units, termed organoids, partially modelling tissue function and regeneration.Here we demonstrated 3D self-assembly adult induced pluripotent stem cell (iPSC)-derived fibroblasts, keratinocytes endothelial progenitors both, planar human skin in vivo a novel type spheroid-shaped organoids vitro, under the aegis platelet...
Background: Immunotherapies targeting α-synuclein aim to limit its extracellular spread in the brain and prevent progression of pathology Parkinson’s disease (PD). PD03A is a specific active immunotherapy (SAIT) involving immunization with short peptide formulation. Objective: This phase 1 study characterized safety tolerability patients early PD. A key secondary objective was evaluate immunological activity following immunization. Methods: two different doses versus placebo PD patients....
Vaccines are a promising therapy for the treatment of chronic conditions such as pruritus. IL-31 has been identified an important mediator itch. By targeting signaling with immunotherapy, CP can be effectively alleviated. However, self-antigens highly tolerated, which rendered conventional conjugate vaccines (CCVs) ineffective at generating sufficient antibody (Ab) responses to alleviate CP. Novel Win Skin Immune System Trick (WISIT) however have shown induce substantially stronger Ab than...
Although both CD4+ and CD8+ T cells are clearly required to generate long-lasting anti-tumor immunity induced by s.c. vaccination with interleukin 2 (IL-2)-transfected, irradiated M-3 clone murine melanoma cells, some controversy continues about the site mode of T-cell activation in this system. Macrophages, granulocytes, natural killer infiltrate early after injection into either syngeneic euthymic DBA/2 mice or athymic nude eliminate inoculum within 48 hr. We could not find at site, which...
We have established a model for the immunologic rejection of melanoma cells. Using receptor-mediated, adenovirus-augmented gene delivery system (transferrinfection) we shown that, upon transfection with an IL-2 construct, MHC class I+/class II- murine M-3 cells lose their tumorigenicity in both athymic and euthymic mice. More importantly, found that these cells, which produce high levels IL-2, can be used to induce long-lasting anti-tumor immune response syngeneic DBA/2 mice but not animals....
Recent evidence suggests Alzheimer-Disease (AD) to be driven by aggregated Aß. Capitalizing on the mechanism of molecular mimicry and applying several selection layers, we screened peptide libraries for moieties inducing antibodies selectively reacting with Aß-aggregates. The technology identified a pool candidates; two, AFFITOPES AD01 AD02, were assessed as vaccination antigens compared Aβ1-6, targeted epitope. When conjugated Keyhole Limpet Hemocyanin (KLH) adjuvanted aluminum, all three...