A5066788905- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Cleft Lip and Palate Research
- Ear Surgery and Otitis Media
- Bacterial Infections and Vaccines
- Tracheal and airway disorders
- Pneumonia and Respiratory Infections
- Sleep and related disorders
- Craniofacial Disorders and Treatments
- Genetic Syndromes and Imprinting
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Airway Management and Intubation Techniques
- Temporomandibular Joint Disorders
- Child and Adolescent Health
- Child Nutrition and Feeding Issues
- Children's Physical and Motor Development
- Restraint-Related Deaths
- Genetic and Kidney Cyst Diseases
- Cardiovascular and Diving-Related Complications
- Cardiovascular Syncope and Autonomic Disorders
- Congenital Ear and Nasal Anomalies
- Sleep and Wakefulness Research
- Cancer-related molecular mechanisms research
- Genomic variations and chromosomal abnormalities
- Heart Rate Variability and Autonomic Control
Chiang Mai University
2014-2024
King Saud University
2016
King Saud bin Abdulaziz University for Health Sciences
2016
Acute otitis media (AOM) is an important cause of childhood morbidity and antibiotic prescriptions. However, the relative importance well-known otopathogens, Streptococcus pneumoniae (Spn) Haemophilus influenzae (Hflu), remains unclear because a limited number tympanocentesis-based studies that vary significantly in populations sampled, case definitions heptavalent pneumococcal conjugate vaccine use.
Streptococcus pneumoniae (S. pneumoniae) and Haemophilus influenzae (H. influenzae) are considered major causes of bacterial acute otitis media (AOM) worldwide, but data from Asia on primary AOM limited. This tympanocentesis-based, multi-center, cross-sectional study assessed etiology antimicrobial susceptibility in Thailand. Children 3 to 59 months presenting with (< 72 hours onset) who had not received prescribed antibiotics, or subjects antibiotics remained symptomatic after 48–72...
Abstract Background There are different findings on heart rate variability (HRV) and pediatric obstructive sleep apnea (pOSA) by an overnight HRV or a 1-hr HRV. However, there is limited data of pOSA diagnosis using 24-h test. This study aimed to evaluate if had potential for OSA Methods was prospective included children age between 5 15 years old, presenting with snoring, underwent polysomnography Holter monitoring. Predictors were analyzed logistic regression analysis. Results During the...
We report on two daughters and a son of Thai family who were affected with BWS. Their clinical findings consist cleft palate, omphalocele, anterior ear creases, indented lesions the posterior rim helix, macroglossia, crossbite, open bite. The younger daughter had newly recognized BWS including sensorineural hearing loss supernumerary flexion creases fingers. A novel mutation in CDKN1C (c.579delT; p.A193AfsX46) was found all individuals their mother. This is located central highly polymorphic...
Objective: To investigate dental anomalies and the molecular etiology of a patient with Ellis−van Creveld syndrome two patients Bardet−Biedl syndrome, examples ciliopathies. Patients Methods: Clinical examination, radiographic evaluation, whole exome sequencing, Sanger direct sequencing were performed. Results: Patient 1 had delayed development or tooth agenesis, multiple frenula, feature found only in mutations ciliary genes. A novel homozygous mutation EVC2 (c.703G>C; p.Ala235Pro) was...
Abstract Treacher Collins syndrome (TCS: OMIM 154500) is an autosomal dominant craniofacial disorder belonging to the heterogeneous group of mandibulofacial dysostoses. Objective To investigate four patients Sgaw Karen family living in Thailand. Method Clinical examination, hearing tests, lateral cephalometric analyses, Computed tomography, whole exome sequencing and Sanger direct were performed. Results All affected with carried a novel TCOF1 mutation (c.4138_4142del; p.Lys1380GlufsTer12),...
OBJECTIVE To evaluate the correlation between chin-throat length and oropharyngeal volume, minimum axial area, polysomnographic indices in patients undergoing orthodontic treatment. METHODS The study enrolled 73 (35 men 38 women) who met inclusion criteria. face scanner created a 3D facial simulation, was subsequently measured. CBCT images were used to simulate 2D lateral cephalometric images. Oropharyngeal volume area determined using Dolphin imaging software, airway function assessed...
Children with moderate-to-severe obstructive sleep apnea (OSA) require specific management. However, the risk factors associated this level of severity in pediatric OSA remain poorly defined. This study aimed to identify clinical predictors OSA.
Undetected obstructive sleep apnea (OSA) in children increases the likelihood of perioperative respiratory complications. Current screening tools for OSA often lack sensitivity or are overly complex. This study aimed to develop and validate a simplified preoperative predictive model moderate-to-severe pediatric OSA. The included aged 1 18 years who underwent either polysomnography nocturnal pulse oximetry from January 2013 December 2020. severity was categorized using these tests, potential...
Background . Radiofrequency ablation (RFA) is recommended as the second-line treatment for obstructive sleep apnea (OSA). This study aims to factors associated with successful by RFA in OSA patients first-line treatment. Methods All diagnosed mild moderate were enrolled prospectively and treated RFA. Three points of soft palate ablated: midline, left, right paramedian sites. Baseline characteristics clinical including snoring score (SS), Epworth Sleepiness Scale (ESS), apnea-hypopnea index...
Most Asian countries have limited resources for polysomnography. Risk factors Obstructive Sleep Apnea (OSA) in populations may be different from the Western countries. Knowing physical risk OSA may a helpful tool clinicians to select suitable patients tested OSA. We enrolled consecutive OSAsuspected patients between October 1st, 2006 and September 30th, 2007. Physical including Body Mass Index (BMI), Neck Circumference (NC), Waist (WC) were recorded. The correlations of BMI, NC, WC...
Objectives: This study aimed to evaluate differences in the upper pharyngeal airway morphology between Thai children with repaired unilateral cleft lip and palate (UCLP) non-cleft children. Methods: prospective used cone beam computed tomography (CBCT) polysomnography (PSG) studies. The subjects were 34 UCLP (21 males 13 females; mean age 8.94±1.87); 32 (20 12 10.03±1.91). Dolphin imaging software measured volume most constricted cross-sectional (version 11.7 premium). Results: An...
Obstructive sleep apnea causes a marked decrease in lung volume and increases elasticity obese adults. However, pulmonary respiratory muscle function of children with obstructive who are more prone to develop airway obstruction than adults is less understood. This study aimed determine the effects on adolescents compared those without apnea.This cross-sectional enrolled 12 known polysomnographic diagnosis controls that were matched for age, gender, body mass index. Pulmonary function,...
Objectives: Obstructive sleep apnea (OSA) is increasingly a concern for risk factor of poor pregnancy outcomes. However, to date, most research studies have relied on subjective such as Epworth Sleepiness Scale (ESS). Therefore, our design used polysomnography, which an objective measurement define OSA in pregnancy. The study aimed measure the incidence pregnancy, reveal clinical examination will be screening tool and prove that Methods: Fifty healthy pregnant women who received antenatal...
Objective: To report the clinical and radiographic findings molecular etiology of first monozygotic twins affected with Pfeiffer syndrome. Methods: Clinical examination whole exome sequencing were performed on two Results: An acceptor splice site mutation in FGFR2 (c.940-2A>G) was detected both twins. The father shared same haplotype, indicating that mutant allele from their father’s chromosome who suffered severe upper airway obstruction subsequent obstructive sleep apnea. Hypertrophy...