ABSTRACT Introduction: Glucocerebrosidase 1 mutations, the most common genetic contributor to Parkinson's disease (PD), have been associated with decreased glucocerebrosidase enzymatic activity in PD patients mutations (glucocerebrosidase 1–PD). However, it is unknown whether this decrease leads lysosphingolipid accumulations. Methods: The levels of hexosylsphingosines, globotriaosylsphingosine, sphingomyelin, and sphingomyelin‐509 were measured dried blood spots from 1–PD (n = 23), sporadic...

Актуальность Ишемическая болезнь сердца (ИБС) занимает лидирующую позицию среди причин смертности во всем мире. Сохраняется необходимость поиска новых эпигенетических маркеров, определяющих риск и прогноз ИБС. Цель Оценить уровень экспрессии микроРНК-21 в крови миокарде правого предсердия у больных ИБС, перенесших коронарное шунтирование (КШ). Материал методы В исследование включено 98 КШ, 40 пациентов без ИБС (группа сравнения) сопоставимого возраста, операцию по поводу клапанных пороков...

To assess prevalence of metabolically healthy individuals among patients with abdominal obesity (AO) and to determine phenotype potential genetic traits associated a benign metabolic status.503 AO without cardiovascular diseases were examined. Waist circumference (WC), BMI, blood pressure, plasma glucose serum insulin levels, HOMA-IR, lipid profile, adiponectin (AN) leptin (LEP) concentrations in measured. Polymorphisms A19G Q223R the LEP receptor gene, G276T T45G AN gene investigated.91.3%...

Abstract Background Recent studies have focused on the potential role of epicardial adipose tissue (EAT) in development coronary artery disease (CAD). ABCA1 and ABCG1 transporters regulate cell cholesterol content reverse transport. We aimed to determine whether DNA methylation mRNA levels genes EAT subcutaneous (SAT) were associated with CAD. Methods Paired SAT samples collected from 82 patients undergoing elective cardiac surgery either for bypass grafting (CAD group, N = 66) or valve...

Tissue specific expression of genes encoding cholesterol transporters ABCA1 and ABCG1 as well the most important transcriptional regulators adipogenesis - LXRa, LXRb, PPARg RORa has been investigated in intraabdominal adipose tissue (IAT) samples.A direct correlation between content proteins with protein level (r=0.480, p<0.05; r=0.435, p<0.05, respectively) suggests role transcription factor regulation IAT levels. gene positively correlated obesity indicators such body mass index (BMI)...

Omentin-1 and fatty acid-binding protein 4 (FABP4) are adipose tissue adipokines linked to obesity-associated cardiovascular complications. The aim of this study was investigate epicardial (EAT) omentin-1 FABP4 gene expression in obese non-obese patients with coronary artery disease (CAD). mRNA levels EAT paired subcutaneous (SAT) as well adipokine serum concentrations were assessed 77 individuals (61 CAD; 16 without CAD (NCAD)). level decreased when compared NCAD (p=0.001). SAT respect...

Background. Imidazoline receptor agonist moxonidine besides its antihypertensive effect, can increase insulin sensitivity, reduce leptin level, improve lipid metabolism. However, the efficacy, tolerability and pleiotropic effects of in postmenopausal women with essential hypertension (EH) metabolic syndrome (MS) are not well established, it was objective this study. Design methods. 30 EH MS (52,5 ± 0,4 years old) were included. Moxonidine administered (400-600 mkg/day) for 12 weeks. Waist...

Coronary artery disease (CAD) remains the leading cause of death and disability in developed countries. Using traditional risk factors for CAD, it is possible to predict likelihood acute coronary events no more than 50% cases. Therefore, study influence genetic epigenetic on development CAD extremely important. Research recent years has shown that vitamin D deficiency a new factor atherosclerosis immune inflammation. Vitamin implements protective effects against inflammation through...

Adiponectin levels, lipid profile and parameters of glucose metabolism were evaluated in patients with abdominal obesity. It was found that adiponectin level negatively correlated body mass index (BMI). The significant correlations between levels adiponectin, triglycerides, high-density lipoprotein (HDL) cholesterol Patients obesity arterial hypertension had higher total cholesterol, low-density (LDL) triglycerides comparing to non-hypertensive BMI increase positively insulin resistance...

Aim. To reveal the molecular genetic predictors of adverse clinical course coronary heart disease (CHD). Material and methods. A investigation performed, 567 CHD patients, those 199 underwent dynamic follow-up. Genotypes Pro12Pro, Pro12Ala, Ala12Ala gene PPAR- γ 2 , genotypes L162L L162V α A603A, A603G, G603G tissue factor were assessed with polymerase chain reaction further restrictional analysis. Results. Carriage allele V162 Ala12 is associated development following endpoints in patients:...

Background. Omentin-1 (QM-1) — one of the most important anti-inflammatory adipocytokines produced by adipose tissue. It is known that its concentration reduced in obese patients. However, role OM-\ pathogenesis coronary heart disease (CHD), including acute syndrome (ACS), not fully determined. T he objective study to assess level OM-1 blood serum patients with ACS without ST-segment elevation (ACSWEST) who underwent percutaneous intervention (PCI) and stable CHD. Design methods. Examined...

Objective To study the role of epicardial adipose tissue (EAT) in determination risk for adverse course ischemic heart disease (IHD) patients after myocardial revascularization.Materials and Methods This included 217 subjects, 182 IHD 35 evaluated individuals without IHD. Percutaneous coronary intervention (PCI) was performed 104 bypass (CB) 78 patients. Also echocardiography (EchoCG) cardiac computed tomography were performed.Results In patients, EAT volume thickness greater than subjects...

Background. Thyroid hormones regulate vascular contractility and relaxation. Subclinical hypothyroidism (SH) can cause arterial stiffness an increase in peripheral vessel resistance. It lead to atherogenic dyslipidemia, hyperhomocysteinemia potentiate atherogenesis coronary artery disease (CAD) hypertension (HTN). Objective. To study thyroid function CAD HTN, as well its role specify indications for screening. Design methods. We examined 870 patients, who underwent coronarography. Height,...

Objective: to investigate influence of different forms adiponectin on carotid intima-media thickness (CIMT) in women with abdominal obesity (AO) St.-Petersburg. It has been recognized before that AO is associated cardiovascular diseases, including atherosclerosis, but mechanism this association remains unclear. leads imbalance adipokines, particularly decrease adiponectin, which may lead atherosclerotic lesion arteries. Materials and methods. We investigated 81 (IDF criteria, 2005) 21 normal...

Objective. The activity of renin-angiotensin-aldosterone system (RAAS) is increased in patients with ab-dominal obesity (AO). However, till present time it unclear whether RAAS activation or hypertension (HTN) found 50 % the primary disorder. Design and methods. We have studied plasma renin (PRA), aldosterone concentration (PAC), their ratio PAC/PRA AO related HTN subjects without AO. Results. PRA was higher versus people (2,5 ± 0,2 1,7 0,7 ng/ml/hr, p = 0,013), there a tendency to reduction...

Objective: To assess the prevalence and forms of metabolic syndrome in patients with abdominal obesity population St Petersburg according to criteria International Diabetic Federation (IDF, 2005) European Cardiology Society (ESH ESC, 2007). Design methods. 966 employees, aged 30-55 years, were examined. Waist circumference, weight, body mass index (BMI), height, blood pressure measured. The levels total cholesterol, triglycerides (TG), low- high- density cholesterol (LDL-C HDL-C), glucose...

Aim. The purpose of the review is to summarize results studies on relationship between level omentin-1 and coronary artery disease (CAD). Key points. Adipose tissue currently considered as an endocrine organ synthesizing biologically active factors known adipocytokines, which may be involved in pathogenesis obesity-related metabolic cardiovascular diseases, particular, CAD. Omentin-1 adipocytokine that predominantly secreted by visceral adipose plays important role development chronic...

The literature review presents an analysis of domestic and foreign publications, modern clinical guidelines for infective endocarditis. Based on the data, main directions examination patients with endocarditis, including complicated forms disease, were determined. Approaches to treatment prevention endocarditis are analyzed. Modern aspects surgical this pathology considered.

The literature review presents an analysis of domestic and foreign publications, modern clinical recommendations for infective endocarditis. Based on the data, a change in structure pathogens endocarditis was established, where Staphylococcus aureus occupies leading place. Algorithms examining patients with have been analyzed. It has shown that role nuclear imaging methods diagnosis this pathology increased. According to latest management endocarditis, diagnostic criteria disease not changed...

Background. Cardiovascular disease, including coronary artery disease (CAD), remains a leading cause of mortality. The results recent studies demonstrate that microRNA engages in pathogenesis different pathological states, atherosclerosis and its clinical manifestation — CAD. Objective. To evaluate microRNA-27а, microRNA-133а microRNA-203 expression cardiomyocytes blood serum CAD patients with degrees lesion. Design methods . 100 were included the study, they formed 3 groups: 40 significant...