A5056303054- Liver Disease Diagnosis and Treatment
- Receptor Mechanisms and Signaling
- Diet, Metabolism, and Disease
- Advanced Glycation End Products research
- Cardiac Fibrosis and Remodeling
- Endoplasmic Reticulum Stress and Disease
- Medicinal Plants and Bioactive Compounds
- Phytase and its Applications
- Signaling Pathways in Disease
- Drug-Induced Hepatotoxicity and Protection
- Plant nutrient uptake and metabolism
- Peroxisome Proliferator-Activated Receptors
- Soil Carbon and Nitrogen Dynamics
- Renin-Angiotensin System Studies
- Liver Disease and Transplantation
- Protein Tyrosine Phosphatases
- Galectins and Cancer Biology
- Cholesterol and Lipid Metabolism
- Adenosine and Purinergic Signaling
Northwest A&F University
2024
Yanbian University
2022-2024
Wenzhou Medical University
2022-2024
Beihua University
2024
Hangzhou Medical College
2022
Increasing evidence implicates chronic inflammation as the main pathological cause of diabetic nephropathy (DN). Exploration key targets in inflammatory pathway may provide new treatment options for DN. We aimed to investigate role Src homology 2–containing protein tyrosine phosphatase 2 (SHP2) macrophages and its association with The upregulated phosphorylation SHP2 was detected both patients diabetes a mouse model. Using macrophage-specific SHP2-knockout (SHP2-MKO) mice SHP2fl/fl injected...
An overdose of acetaminophen (APAP) causes acute liver damage and lead to failure. Therefore, it is great clinical significance find drugs for the treatment APAP-induced injury. Diacerein clinically used drug osteoarthritis. Here, we evaluate pharmacological effects potential mechanisms diacerein in injury.C57BL/6 mice were treated with by gavage, followed intraperitoneal injection APAP (400 mg/kg) induce injury mice. RNA-sequencing analysis vitro kinase assay performed explore underlying...
Heart failure is a fairly common outcome of hypertension. Recent studies have highlighted the key role non-hemodynamic activity angiotensin II (Ang II) in hypertensive heart via inducing cardiac inflammation. Drugs that disrupt Ang II-induced inflammation may clinical utility treatment failure. A naturally occurring compound, corynoline, exhibit anti-inflammatory activities other systems. C57BL/6 mice were injected with micro-osmotic pump for four weeks to develop The treated corynoline by...
Abstract Chronic inflammation plays an important role in hypertensive heart failure. Suppressing angiotensin II (Ang II)‐induced cardiac may contribute to the treatment of hypertension‐associated Sclareol, a natural product initially isolated from leaves and flowers Salvia sclarea , possesses antiinflammatory immune‐regulation activity various systems. However, its effect on Ang II‐induced remodeling remains unknown. In this study, we have explored potential effects sclareol vivo experiments...
Increasing evidence implicates chronic inflammation as the main pathological cause of diabetic nephropathy (DN). Exploration key targets in inflammatory pathway may provide new treatment options for DN. Here, we aim to investigate role Src Homology 2 Containing Protein Tyrosine Phosphatase (SHP2) macrophages and its association with The upregulated phosphorylation SHP2 was detected both patients mouse model. Using macrophage-specific knockout mice (SHP2-MKO) SHP2<sup>fl/fl...
Increasing evidence implicates chronic inflammation as the main pathological cause of diabetic nephropathy (DN). Exploration key targets in inflammatory pathway may provide new treatment options for DN. Here, we aim to investigate role Src Homology 2 Containing Protein Tyrosine Phosphatase (SHP2) macrophages and its association with The upregulated phosphorylation SHP2 was detected both patients mouse model. Using macrophage-specific knockout mice (SHP2-MKO) SHP2<sup>fl/fl...