A5005117240- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Genomics, phytochemicals, and oxidative stress
- Cancer Research and Treatments
- Nanoparticle-Based Drug Delivery
- RNA Research and Splicing
- Nanoplatforms for cancer theranostics
- Lung Cancer Research Studies
- Kruppel-like factors research
- Synthesis and Reactions of Organic Compounds
- Hemoglobinopathies and Related Disorders
- Ferroptosis and cancer prognosis
- Esophageal Cancer Research and Treatment
- IL-33, ST2, and ILC Pathways
- DNA Repair Mechanisms
- Telomeres, Telomerase, and Senescence
- Genomic variations and chromosomal abnormalities
- Cell death mechanisms and regulation
- Galectins and Cancer Biology
- Fibroblast Growth Factor Research
- Protease and Inhibitor Mechanisms
- Acute Lymphoblastic Leukemia research
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Beijing University of Chemical Technology
2014-2023
Accumulated evidence demonstrated that long non-coding RNAs (lncRNAs) play a pivotal role in tumorigenesis. However, it is still largely unknown how these lncRNAs were regulated by small ncRNAs, such as microRNAs (miRNAs), at the post-transcriptional level. We here use lncRNA HOTTIP an example to study miRNAs impact expression and its biological significance hepatocellular carcinoma (HCC). LncRNA vital oncogene HCC, one of deadliest cancers worldwide. In current study, we identified miR-192...
Enzymes have been used to direct the conversion of prodrugs in cancer therapy. However, non-specific distribution endogenous enzymes seriously hinders their bioapplications. Herein, we developed a near-infrared-triggered locoregional chemo-photothermal therapy based on exogenous enzyme delivery and remolded tumor mivroenvironment. The catalytic efficiency was enhanced by hyperthermia, therapeutic efficacy photothermal (PTT) improved owing inhibition heat shock protein 90 chemotherapeutics....
Abstract Esophageal cancer is one of the most common with limited therapeutic strategies, thus it important to develop more effective strategies against it. Sulforaphene (SFE), an isothiocyanate isolated from radish seeds, was proved inhibit esophageal progression in current study. Flow cytometric analysis showed SFE induced cell apoptosis and cycle arrest G2/M phase. Also, scrape motility transwell assays presented reduced metastasis. Microarray results influence on cells related...
5S rRNA plays an important part in ribosome biology and is over-expression multiple cancers. In this study, we found that a direct target of miR-150 miR-383 esophageal squamous cell carcinoma (ESCC). Overexpression inhibited ESCC proliferation vitro vivo. Moreover, silencing by might intensify rpL11-c-Myc interaction, which attenuated role c-Myc as oncogenic transcriptional factor dysregulation genes. Taken together, our results highlight the involvement miRNAs ribosomal regulation during...
treRNA is a long non‐coding RNA (lncRNA) involved in cancer progression. In this study, we show that miR‐190a can silence post‐transcriptionally. Suppression of by led to significant changes mesenchymal–epithelial transition markers and impaired migration invasion capability hepatoma cells. TCGA data indicated exhibited lower expression tissues, especially from patients with vascular tumor invasion, compared normal tissues. Our results reveal the involvement miR‐190a–treRNA axis progression...
Abstract Metallopeptidase 13 ( MMP13 ), a well-known and highly regulated zinc-dependent MMP collagenase, plays crucial part in development progression of esophageal squamous cell carcinoma (ESCC). Therefore, we examined associations between ESCC susceptibility four haplotype-tagging single nucleotide polymorphisms (htSNPs) using two stage case-control strategy. Odds ratios (OR) 95% confidence intervals (95% CI) were computed by logistic regression model. After analyzing 1588 patients...
As a well-known oncogene, B cell lymphoma-2 (BCL-2) can promote cancer survival through preventing their apoptosis. Several functional BCL-2 single nucleotide polymorphisms (SNPs), such as rs2279115, rs1801018, and rs1564483, have been identified might contribute to susceptibility. However, the involvement of these SNPs in small lung (SCLC) was still unclear. result, we investigated associations between three genetic variants SCLC risk case-control design. Genotypes were determined two...
Understanding the mechanism by which sulforaphene (SFE) affects esophageal squamous cell carcinoma (ESCC) contributes to application of this isothiocyanate as a chemotherapeutic agent. Thus, we attempted investigate SFE regulation ESCC characteristics more deeply. We performed gene set enrichment analysis (GSEA) on microarray data SFE-treated cells and found that differentially expressed genes are enriched in TNFα_Signaling_via_the_NFκB_Pathway. Coupled with expression profile from GSE20347...
Abstract Enzymes have been used to direct the conversion of prodrugs in cancer therapy. However, non‐specific distribution endogenous enzymes seriously hinders their bioapplications. Herein, we developed a near‐infrared‐triggered locoregional chemo‐photothermal therapy based on exogenous enzyme delivery and remolded tumor mivroenvironment. The catalytic efficiency was enhanced by hyperthermia, therapeutic efficacy photothermal (PTT) improved owing inhibition heat shock protein 90...