A5052805497- Advanced Chemical Sensor Technologies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Analytical Chemistry and Chromatography
- Metabolomics and Mass Spectrometry Studies
- Olfactory and Sensory Function Studies
- Inhalation and Respiratory Drug Delivery
- Respiratory Support and Mechanisms
- Gas Sensing Nanomaterials and Sensors
- Biosensors and Analytical Detection
- Insect Pheromone Research and Control
- IL-33, ST2, and ILC Pathways
- Respiratory viral infections research
- Airway Management and Intubation Techniques
- Occupational and environmental lung diseases
- Air Quality and Health Impacts
- Indoor Air Quality and Microbial Exposure
- Pediatric health and respiratory diseases
- Marine animal studies overview
- Chronic Lymphocytic Leukemia Research
- Biochemical Analysis and Sensing Techniques
- Nursing Diagnosis and Documentation
- Occupational exposure and asthma
- Innovative Microfluidic and Catalytic Techniques Innovation
University of California, Davis
2016-2025
University of California Davis Medical Center
2012-2024
University of California System
2023
VA Northern California Health Care System
2015-2022
Children's Hospital Colorado
2021
University of Colorado Denver
2021
Riley Hospital for Children
2020
Indiana University – Purdue University Indianapolis
2020
Indiana University Indianapolis
2020
Pulmonary and Critical Care Associates
2010-2018
Many patients with breathlessness and chronic obstructive lung disease are diagnosed either asthma, COPD, or—frequently—mixed disease. More commonly, uncharacterized treated therapies that target asthma COPD rather than one of these diseases. This common practice represents the difficulty in distinguishing disorders clinically, particularly a history does not easily differentiate from COPD. A clinical scenario is an older former smoker partially reversible or fixed airflow obstruction...
A 46-year-old previously healthy female developed flu-like symptoms several days prior to presenting a local hospital. The patient did not note recent travel history, specifically denying China. Sick contact exposure was known. Chest X-ray and computed tomography of the chest showed findings concerning for lobar pneumonia. Subsequent radiology studies worsening lung along with respiratory necessitating intubation ventilation. She transferred university hospital due need an elevated level...
Volatile organic compounds (VOCs) emanating from humans have the potential to revolutionize non-invasive diagnostics. Yet, little is known about how these are generated by complex biological systems, and even less reflective of a particular physiological state. In this proof-of-concept study, we examined VOCs produced directly at cellular level B lymphoblastoid cells upon infection with three live influenza virus subtypes: H9N2 (avian), H6N2 H1N1 (human). Using single cell line helped...
Respiratory viral infections such as human rhinovirus (HRV) can lead to substantial morbidity and mortality, especially in people with underlying lung diseases asthma COPD. One proposed strategy detect non-invasively is by volatile organic compound (VOC) assessment via analysis of exhaled breath. The epithelial cells are one the most important cell lines affected during respiratory they first line pathogen defense. Efforts discover infection-specific biomarkers be significantly aided...
Background: Personalized education and treatment selection can improve health behaviors outcomes in patients with COPD. However, many COPD have incomplete knowledge of their disease, which leads to undertreated symptoms. We hypothesized that an interdisciplinary care approach respiratory therapists (RTs) integrated our dedicated clinic will significantly affect as measured by Assessment Test (CAT) scores, exacerbation rates, COPD-related hospitalizations. Methods: This study was a...
Airway obstruction from blood clots, airway secretions, and foreign bodies is a potentially life-threatening condition. Optimal management of this problem, whether by rigid or flexible bronchoscopy, has not been well studied. We report our single-center experience on the safety clinical utility cryoprobe extraction for indication.We performed retrospective chart review January 2006 to November 2014 all subjects aged 18 older who underwent bronchoscopic extraction. Subjects with due benign...
This is the first known community transmission case of novel coronavirus disease (COVID-19) in United States, with significant public health implications. Diagnosis COVID-19 currently confirmed PCR based testing appropriate respiratory samples. Given absence travel or exposure history, this patient did not meet criteria for according to CDC guidelines at time her presentation. Since case, any severe (eg, ARDS pneumonia) requiring hospitalization without an explanatory diagnosis can be tested...
As the world continues to grapple with ongoing SARS-CoV-2 pandemic, it remains clear that frequent and widespread virus testing is a valuable tool understand disease spread guide public health actions by communities governments. To date, most traditional diagnostic tests continue rely on established polymerase chain reaction (PCR) technologies, which have proven be quite robust as for mass screening remain gold standard within modern medicine. When employed using standardized protocols, PCR...
Exhaled breath condensate (EBC) analysis is a developing field with tremendous promise to advance personalized, non-invasive health diagnostics as new analytical instrumentation platforms and detection methods are developed. Multiple commercially-available researcher-built experimental samplers reported in the literature. However, there very limited information available determine an effective sampling approach, especially regarding dependence of sample metabolomic content on collection...
Asthma affects over 300 million people worldwide. Asthmatics experience difficulty in breathing and airflow obstruction caused by inflammation constriction of the airways. Home monitoring lung function is preferred course action to give physicians asthma patients a chance control disease jointly. Thus, it important develop accurate efficient devices that are easy for use. While classic spirometry currently best way capture complete picture function, machines bulky generally require...
Acute fibrinous and organizing pneumonia (AFOP) is an extremely rare, relatively new, distinct histological pattern of acute lung injury characterized predominately by the presence intra-alveolar fibrin associated pneumonia. AFOP may be idiopathic or with a wide spectrum clinical conditions. It has variable presentation from mild respiratory symptoms to that similar distress syndrome. Currently there no consensus on treatment, corticosteroids previously were unclear benefit. To date, are...
Abstract Background Severe coccidioidomycosis presenting with respiratory failure is an uncommon manifestation of disease. Current knowledge this condition limited to case reports and small series. Methods A retrospective multicenter review patients coccidioidomycosis-associated acute distress syndrome (CA-ARDS) was conducted. It assessed clinical laboratory variables at the time presentation, reviewed treatment course, compared cohort a national database noncoccidioidomycosis ARDS....
Exhaled human breath contains thousands of chemicals that are potential biomarkers disease or chemical exposure. Although many bench-top analytical instruments could measure concentrations these chemicals, small and portable systems have the best advantage being used in a clinical point-of-care environment field setting. Here, we demonstrate coupling miniature differential mobility spectrometer (DMS) with both gas chromatograph (GC) separately an electrospray ionization (ESI) module to...
Health assessments of wild cetaceans can be challenging due to the difficulty gaining access conventional diagnostic matrices blood, serum and others. While noninvasive detection metabolites in exhaled breath could potentially help address this problem, there exists a knowledge gap regarding associations between known disease states metabolite profiles cetaceans. This technology was applied largest marine oil spill U.S. history (The 2010 Deepwater Horizon Gulf Mexico). An accurate analysis...
Asthma and chronic obstructive pulmonary disease (COPD) are distinct but clinically overlapping airway disorders which often create diagnostic therapeutic dilemmas. Current strategies to discriminate these diseases limited by insensitivity poor performance due biologic variability. We tested the hypothesis that a gas chromatograph/differential mobility spectrometer (GC/DMS) sensor could distinguish between well-defined groups with based on volatile organic compounds (VOCs) obtained from...