A5045776598- Viral Infections and Outbreaks Research
- Vaccine Coverage and Hesitancy
- Disaster Response and Management
- Ethics in Clinical Research
- Viral Infections and Vectors
- Global Security and Public Health
- Hepatitis B Virus Studies
- Biometric Identification and Security
- Alcohol Consumption and Health Effects
- Data-Driven Disease Surveillance
- Global Maternal and Child Health
- Substance Abuse Treatment and Outcomes
- COVID-19 epidemiological studies
- COVID-19 Pandemic Impacts
- Health and Wellbeing Research
- Healthcare Systems and Reforms
- Respiratory viral infections research
- Zoonotic diseases and public health
- Geriatric Care and Nursing Homes
- Infant Nutrition and Health
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Bacillus and Francisella bacterial research
- Youth, Drugs, and Violence
- vaccines and immunoinformatics approaches
University of Antwerp
2019-2025
This article describes the protocol of an Ebola vaccine clinical trial which investigates safety and immunogenicity a two-dose prophylactic regimen comprised two vaccines (Ad26.ZEBOV MVA-BN-Filo) administered 56 days apart, followed by booster vaccination with Ad26.ZEBOV offered at either 1 year or 2 years (randomisation 1:1) after first dose. is part EBOVAC3 project (an Innovative Medicines Initiative Joint Undertaking), to evaluate different arms in large cohort adults.
Enrichment of breast milk (BM) with immunoglobulin (Ig) A and IgG through maternal vaccination could help infants combat targeted pathogens. However, evidence on this effect after preterm delivery is lacking. In study, we investigated the total anti-pertussis toxin (anti-PT)-specific IgA production in BM term presence Tdap (tetanus, diphtheria, acellular pertussis) vaccination.Serum samples lactating women who delivered at or prematurely did not receive vaccine (Boostrix, GSK Biologicals)...
Since the largest Ebola outbreak in West Africa (2013-2016) highlighted potential threat of virus to world, several vaccines have been under development by different pharmaceutical companies. To obtain vaccine licensure, trials assessing safety, immunogenicity and efficacy new among populations (e.g. age, gender, race, ethnicity) play a crucial role. However, while this deadly disease mainly affects Central Africa, clinical trial regulations are becoming increasingly complex consequently...
In response to recent Ebola epidemics, vaccine development against the Zaire ebolavirus (EBOV) has been fast-tracked in past decade. Health care providers and frontliners working Ebola-endemic areas are at high risk of contracting spreading virus.
A partnership between the University of Antwerp and Kinshasa implemented EBOVAC3 clinical trial with an Ebola vaccine regimen administered to health care provider participants in Tshuapa Province, Democratic Republic Congo. This randomized controlled was part outbreak preparedness initiative financed through Innovative Medicines Initiative-European Union. The used iris scan technology identify all enrolled trial, ensure that right participant received at visit.We aimed assess acceptability,...
The long-term retention of information disclosed during the informed consent in clinical trials lasting over a year cannot be guaranteed for all volunteers. This study aimed to assess level participants' and understanding trial after two years participation vaccine trial.
ABSTRACT. This study explored the experiences of healthcare providers (HCPs) and frontline workers who were involved in an Ebola vaccine trial Democratic Republic Congo. The researchers interviewed a total 99 participants (HCPs workers) living working Boende health district during period study, from February to March 2022. These individuals included mix non-trial (staff trial, local authorities, head nurses centers). In-depth individual interviews, as well focus group discussions (FGDs),...
The wildlife reservoir and spillover mechanisms of the Ebola virus remain elusive despite extensive research efforts in endemic areas. This study employed a One Health approach to examine circulation associated human exposure risks Tshuapa province Democratic Republic Congo. In 2021, we collected 1015 samples from 888 animals, predominantly small mammals, 380 inhabitants Inkanamongo village, site an disease outbreak 2014. These were screened for evidence current (RNA) or past (IgG...
A serosurvey among health care providers (HCPs) and frontliners of an area previously affected by Ebola virus disease (EVD) in the Democratic Republic Congo (DRC) was conducted to assess seroreactivity antigens.Serum samples were collected a cohort HCPs (n = 698) participants EBL2007 vaccine trial (December 2019 October 2022). Specimens seroreactive for EBOV confirmed using either Filovirus Animal Nonclinical Group (FANG) ELISA or Luminex multiplex assay.The at least two EBOV-Mayinga (m)...
Background: Previous studies have associated certain risk factors with hazardous drinking in students. However, big cultur- al and geographical differences exist regarding alcohol use.
 Objectives: To determine whether or not there was a difference between Belgian South African university students to establish the that contribute (calculated using AUDIT-C) from developing country (South Africa) developed (Belgium).
 Methods: An online survey assessing among Africa (University of...
Implementing an Ebola vaccine trial in a remote area the Democratic Republic of Congo (DRC), and being confronted with dysfunctional health care system acute unmet needs participants, ethical considerations were made regarding ancillary obligations sponsor researchers. Spurred by occurrence non-related (serious) adverse events (NR-SAEs), Universities Antwerp Kinshasa jointly developed algorithm, accompanied algorithm policy. The consists set consecutive questions binary response options,...
In this paper, we discuss challenges associated with implementing a policy for Ancillary Care (AC) related and unrelated (serious) adverse events during an Ebola vaccine trial conducted in remote area of the Democratic Republic Congo. Conducting clinical trials resourceconstrained settings can raise context-related that have implications study participants’ health wellbeing. During study, three participants were injured road traffic accidents, but there unexpected difficulties when trying to...
Conducting a vaccine trial in low- and middle-income country (LMIC) can present unique challenges lessons learned. This Ebola trial, enrolling 699 healthcare providers frontliners jointly set up by the University of Antwerp (Sponsor) Kinshasa (Principal Investigator (PI)), was conducted Boende, remote city Democratic Republic Congo (DRC), between December 2019 October 2022 (ClinicalTrials.gov: NCT04186000). While being bound strict ICH-GCP international funder regulations, this exemplary for...
Iris scanning has increasingly been used for biometric identification over the past decade, with continuous advancements and expanding applications. To better understand acceptability of this technology, we report long-term experiences health care providers frontline worker participants iris as an tool in EBL2007 Ebola vaccine trial conducted Democratic Republic Congo. This study aims to document using identity verification throughout trial. Two years after start (February March 2022), 69...
Introduction Clear guidelines to implement ancillary care (AC) in clinical trials conducted resource-constrained settings are lacking. Here, we evaluate an AC policy developed for a vaccine trial the Democratic Republic of Congo and formulate recommendations. Methods To policy, performed longitudinal cohort study, nested open-label, single-centre, randomised Ebola among healthcare personnel. Participants’ demographic information, residence distance study site details on financial and/or...
Abstract Introduction A serosurvey among health care providers (HCPs) and frontliners of an area previously affected by Ebola virus disease (EVD) in the Democratic Republic Congo (DRC) was conducted to assess seroreactivity antigens. Methods Serum samples were collected a cohort HCPs (n=698) participants EBL2007 vaccine trial (December 2019 October 2022). Specimens seroreactive for EBOV confirmed using either Filovirus Animal Nonclinical Group (FANG) ELISA or Luminex multiplex assay. Results...
<sec> <title>BACKGROUND</title> Iris scanning, as a means of human biometric recognition, has been increasingly deployed over the last decade and continues to improve expand. To better understand acceptability this technology, we report long-term experiences healthcare provider (HCP) frontline worker participants with iris scanning an identification tool in Ebola vaccine (EBL2007 trial) trial conducted Democratic Republic Congo (DRC). </sec> <title>OBJECTIVE</title> document for identity...
Abstract Background Previous studies have associated certain risk factors with hazardous drinking in students. However, big cultural and geographical differences exist regarding alcohol use. In this study, we compare the use Belgian (BE) South African (SA) university Methods An online survey assessing among students Africa (University of KwaZulu-Natal) Belgium Antwerp) was conducted, using shortened version Alcohol Use Disorder Identification Test (AUDIT-C). For male a cut-off point 5 used...
<sec> <title>BACKGROUND</title> A partnership between the University of Antwerp and Kinshasa implemented EBOVAC3 clinical trial with an Ebola vaccine regimen administered to health care provider participants in Tshuapa Province, Democratic Republic Congo. This randomized controlled was part outbreak preparedness initiative financed through Innovative Medicines Initiative-European Union. The used iris scan technology identify all enrolled trial, ensure that right participant received at...