Head direction (HD) cells in the rat anterodorsal thalamic nucleus (ADN) fire relative to animal's directional heading. Lesions of entire vestibular labyrinth have been shown severely alter VIIIth nerve input and disrupt these HD signals. To assess specific contributions semicircular canals without altering tonic input, ADN were recorded from chinchillas after bilateral canal occlusion. Although (and also hippocampal place theta cells) identified intact chinchillas, no direction-specific...

Mammalian vestibular-nerve afferents innervating the semicircular canals have been divided into groups according to their discharge regularity, gain at 2-Hz rotational stimulation, and morphology. Low-gain irregular terminate in calyx endings central crista, high-gain synapse more peripherally dimorphic (bouton calyx) endings, regular peripheral zone as bouton-only endings. The response dynamics of these three described only up 4 Hz previous studies. Reported here are responses chinchilla...

<b><i>Objective:</i></b> In patients with migraine, neurotologic symptoms and signs occur commonly. The authors’ aim was to determine whether findings are in accordance the type of migraine test differ from those healthy controls. <b><i>Methods:</i></b> authors examined 36 various types classified by International Headache Society criteria. Comprehensive tests were performed between attacks: video-oculography (VOG), electronystagmography, static posturography, audiometry on 12 aura (MA) 24...

Gentamicin is toxic to vestibular hair cells, but its effects on afferents have not been defined. We treated anesthetized chinchillas with one injection of gentamicin (26.7 mg/ml) into the middle ear and made extracellular recordings from after 5-25 (early) or 90-115 days (late). The relative proportions regular, intermediate, irregular did change treatment. spontaneous firing rate regular was lower (P < 0.001) side (early: 44.3 +/- 16.3; late: 33.9 13.2 spikes x s(-1)) than untreated (54.9...

Objective--Patients with superior canal dehiscence (SCD) syndrome experience vertigo and oscillopsia loud sounds and/or stimuli that result in changes middle ear or intracranial pressure. Findings on temporal bone CT were analyzed to determine if a developmental abnormality is associated the syndrome. Material methods--Temporal scans [0.5 mm collimation projections into semicircular (SC) plane] used compare overlying SC patients SCD (20 unilateral, 7 bilateral) 88 without who had undergone...

Afferents innervating the superior semicircular canal are rendered especially sensitive to acoustic stimulation when there is a dehiscence of canal. Other vestibular end organs also more stimulation.Dehiscence associated with vertigo and nystagmus caused by loud sounds (Tullio phenomenon) or changes in middle ear intracranial pressures. The mechanisms which stimuli act on unclear. generally aligns affected canal.Responses nerves anesthetized chinchillas were recorded before after...

<h3>Background</h3> Patients with superior canal dehiscence syndrome may experience vertigo and nystagmus when pressure changes occur in the external auditory canal, middle ear, or intracranial space. The cause is a defect bone of canal. <h3>Objective</h3> To study mechanisms sensitivity labyrinth its surgical repair chinchilla model. <h3>Methods</h3> We investigated firing rates vestibular nerve afferents response to before after fenestration fenestra. <h3>Results</h3> Before fenestration,...

Umbilical cord blood (UCB) is an efficient and valuable source of hematopoietic stem cells (HSCs) for transplantation. In addition to HSCs it harbours low amounts mesenchymal (MSCs). No single marker identify blood-derived cells, or indicate their multipotent phenotype, has been characterized so far. SSEA-3 -4 are cell surface globoseries glycosphingolipid epitopes that commonly used as markers human embryonic where rapidly disappears when the start differentiate. Lately have also observed...

Abstract Human multipotent mesenchymal stromal/stem cells ( MSC s) have been shown to exert immunomodulatory properties that great potential in therapies for various inflammatory and autoimmune disorders. However, intravenous delivery of these is followed by massive cell entrapment the lungs insufficient homing target tissues or organs. In targeting tissues, MSCs other therapeutic employ similar mechanisms as leucocytes, including a cascade rolling adhesion steps mediated selectins,...

We examined whether tension neck (TN) may due to inadequate proprioceptive and vestibular activation of the cervico-collic reflex (CCR). CCR vestibulospinal responses (VSRs) were recorded from 106 forest workers by stimulating neck, lumbar or calf proprioceptors vibration. The VSRs with posturography. TN occurred in 27 out subjects. subjects (48.5 years) older than those without (43.1). mean body sway during quiet stance was same both groups stimulation. In stimulation caused excessive,...

Abstract. Epidemiological studies have suggested that patients with rheumatoid arthritis (RA) increased mortality due to cardiovascular disease. We studied cardiac performance in 12 asymptomatic male RA and 14 control subjects elucidate early disturbances function. In echocardiography, isovolumic relaxation time was longer (64 ± 6 vs. 49 3 ms, mean SEM, P = 0.010) peak filling rate (134 10 159 mm s ‐1 , 0.015) lower than subjects, reflecting an impairment left ventricular diastolic Left...

Determine the change in vestibular function patients receiving a unilateral cochlear implant, and to compare these results with other signs symptoms.Prospective cohort study.Academic tertiary referral center.Forty-four adults (mean age, 55 yr; range, 30-76 yr) their first implant.Cochlear implantation.Horizontal high-frequency vestibulo-ocular reflex (VOR) was measured using motorized head impulse rotator preoperatively twice (on average two 19 months) postoperatively. VOR gain asymmetry...

To determine lengths and causes of pre- in-hospital delays in thrombolytic treatment.A prospective national survey covering 48 the 51 Finnish university, central general hospitals to obtain basic data before start a public campaign shorten patient-related delay acute myocardial infarction.One thousand twelve consecutive patients with infarction who received therapy over 3 months 1995 represent 40% all confirmed infarction.The median interval between onset symptoms initiation was 160 min...

Dizziness is a common symptom in elderly people. Head autorotation test (HART) has earlier shown no significant vestibulo-ocular reflex (VOR) disturbances healthy subjects. We used our recently developed HART to determine VOR 14 volunteers without otoneurological diseases and sedative medications. Gain phase were determined 5 frequency bands from 0.5 Hz. The gain of the was significantly increased 1.11-1.27 range 3-5 Hz compared with controls. lead 7-8 degrees 2 4 differed normative values...

Detailed analysis of eye movements is essential in order to understand the pathophysiology underlying vestibular disturbances. We applied a commercial video-oculography (VOG) measure spontaneous and provoked nystagmus 20 healthy subjects. The slow-phase velocity (SPV) was calculated. also simultaneously recorded on standard VHS videotape be able confirm results derived from VOG paper charts. charts simultaneous videotaping agreed well. Nystagmus found 17 Spontaneous seen 20%, positional 55%,...

Our aim was to elucidate the aetiology of persistent postoperative headache, a common sequel for several years after vestibular schwannoma surgery through retrosigmoid approach. Twenty-seven patients with reported major headache were tested responses and cervico-collic reflexes. The role local anaesthesia injected into neck muscle insertions or around occipital nerves evaluated. Sixteen operated on schwannoma, but without 12 healthy volunteers served as control groups. Vestibular reflexes...

Intratympanic and systemic dexamethasone treatment of Ménière’s disease (MD) was evaluated in a prospective study. Seventeen patients (6 men 11 women) with MD (5 right-sided, left-sided 1 bilateral) were treated three 0.2- to 0.4-ml injections intratympanic hyaluronate (16 mg/ml) during week an initial intramuscular injection 15 mg. Most stage 3, the mean duration 5.3 years. Pure-tone speech audiometry symptom scale followed up for year after treatment. Symptoms aural fullness, hearing loss,...

Conclusion: Vestibular disturbance is frequent, but mild even immediately after stapes surgery. symptoms improved or disappeared quickly, and they did not correlate with nystagmus. Outpatient surgery performed under local anaesthesia a feasible approach. Objective: are common may prevent outpatient The time course of vestibular unclear, we aimed to evaluate it the operation in recovery room. Methods: Twenty patients otosclerosis undergoing stapedotomy were prospectively included study....