A5101504324- Planetary Science and Exploration
- Geological and Geochemical Analysis
- Geochemistry and Geologic Mapping
- Surface Roughness and Optical Measurements
- Advanced machining processes and optimization
- Geology and Paleoclimatology Research
- Cellular transport and secretion
- Astro and Planetary Science
- Protein Kinase Regulation and GTPase Signaling
- Enzyme Structure and Function
- Advanced Measurement and Metrology Techniques
- Space Science and Extraterrestrial Life
Incyte (United States)
2025
China University of Geosciences
2024
National Space Science Center
2024
Chinese Academy of Sciences
2024
The inhibition of mutant KRAS proteins has emerged as a promising approach for treating KRAS-driven cancers, evidenced by the clinical success G12C inhibitors. G12D, most common mutant, promises significant expansion addressable patient population; however, reduced nucleophilicity aspartate compared to cysteine poses challenges in balancing sufficient potency with ADME properties support oral exposure. Herein, we describe discovery G12D inhibitor 23 (INCB159020), which achieves exposure...
Abstract The chronology function and production have been widely used to derive the model ages of lunar mare regions from crater size‐frequency distributions. Challenges remain in homogenous counting area selection, saturation rim identification. Geological unit‐based are also difficult study continuous surface evolution among adjacent areas. Using regression‐learning models, we tried a new method on Em4 unit Chang'e 5 landing explore quantitative relationship between morphometric...
Abstract Marius Hills, Rümker and Gardner are three prominent volcanic complexes on the lunar nearside characterized by well‐preserved elevated topography, highly concentrated domes/cones, positive gravity anomalies. Here, we perform a comparative study of geology geophysics these using multi‐source remote‐sensing data to better understand volcanism diversity magmatic evolution nearside. Uniform precise feature extraction methods used explore morphological geochemical characteristics their...
摘要: 月球火山穹窿是了解月球火山活动的重要窗口.利用高分辨率多源遥感数据,对月球正面的3个火山复合体区(Marius Hills和Rümker Hills位于风暴洋克里普地体,Gardner在风暴洋克里普地体外)里发育的火山穹窿进行形貌和铁钛元素特征提取,利用这些特征参数进行层次聚类分析,并将所有穹窿划分为7个聚类(DC1~DC7);然后结合流变学、年代学和区域地质背景对3个火山复合体区的火山活动特征进行了综合分析.Marius Hills发育的火山穹窿数量多,高度和坡度较高,以中高钛为主,穹窿代表类型为DC7,岩浆活动时间跨度大(约2.6 Ga)、周期长,表明该区域存在多期次不同特征的火山活动.Rümker Hills发育的火山穹窿数量少,高度和坡度居中,以低钛为主,穹窿代表类型为DC1和DC4,活动时间相对集中(约0.8 Ga).Gardner及其周边区域发育的穹窿呈环状和带状分布,高度和坡度较低,以中低钛为主,岩浆活动时间持续约1.0...