A5075811283- Viral Infections and Immunology Research
- Galectins and Cancer Biology
- Immune Cell Function and Interaction
- Mast cells and histamine
- Immune Response and Inflammation
- Atherosclerosis and Cardiovascular Diseases
- Urticaria and Related Conditions
- Peptidase Inhibition and Analysis
- T-cell and B-cell Immunology
- Kawasaki Disease and Coronary Complications
- Inflammasome and immune disorders
- Drug-Induced Hepatotoxicity and Protection
- Eosinophilic Disorders and Syndromes
- Whipple's Disease and Interleukins
- Lymphoma Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Food Allergy and Anaphylaxis Research
- Signaling Pathways in Disease
- SARS-CoV-2 and COVID-19 Research
- Sepsis Diagnosis and Treatment
- Liver Diseases and Immunity
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Cardiac Fibrosis and Remodeling
- Thermal Regulation in Medicine
Johns Hopkins University
2004-2010
Center for Environmental Health
2007
National Institute of Pathology
2006
Johns Hopkins Medicine
2006
Abstract Recent clinical studies have reinforced the importance of sex-related differences in pathogenesis cardiovascular diseases, with an increased incidence and mortality men. Similar to humans, male BALB/c mice infected coxsackievirus B3 (CVB3) develop more severe inflammation heart even though viral replication is no greater than females. We show that TLR4 IFN-γ levels are significantly elevated regulatory T cell (Treg) populations reduced males following CVB3 infection, whereas females...
Abstract Autoimmune diseases can be reduced or even prevented if proinflammatory immune responses are appropriately down-regulated. Receptors (such as CTLA-4), cytokines TGF-β), and specialized cells CD4+CD25+ T regulatory cells) work together to keep in check. cell Ig mucin (Tim) family proteins key regulators of inflammation, providing an inhibitory signal that dampens thereby reducing autoimmune allergic responses. We show this study Tim-3 signaling during the innate response viral...
Abstract Th1-type immune responses, mediated by IL-12-induced IFN-γ, are believed to exacerbate certain autoimmune diseases. We recently found that signaling via IL-12Rβ1 increases coxsackievirus B3 (CVB3)-induced myocarditis. In this study, we examined the role of IL-12 on development CVB3-induced myocarditis using mice deficient in IL-12p35 lack IL-12p70. deficiency did not prevent myocarditis, but viral replication was significantly increased. Although there were no changes total...
The development of autoimmune disease involves a combination genetic and environmental factors. Many diseases are believed to be triggered by viral infections. Since the early, natural immune response infection can determine later adaptive response, innate immunity likely influences progression from autoimmunity. To investigate role on susceptibility disease, we compared early cytokine mice susceptible or resistant heart following infection. We found that BALB/c produced elevated levels...
Abstract Complement and complement receptors (CR) play a central role in immune defense by initiating the rapid destruction of invading microorganisms, amplifying innate adaptive responses, mediating solubilization clearance complexes. Defects expression C or CR have been associated with loss tolerance to self proteins development complex-mediated autoimmune diseases such as systemic lupus erythematosus. In this study, we examined on coxsackievirus B3 (CVB3)-induced myocarditis using mice...
Abstract Previously we showed that Toll-like receptor 4 (TLR4) and T cell Ig mucin-3 (Tim-3) cross-regulate each others expression on CD11b+ cells, with TLR4 increasing Tim-3 reducing cardiac inflammation. We show here are expressed GR1+F4/80+IL-4R+ alternatively activated M2 macrophages from the heart during acute myocarditis, but not GR1-F4/80+IL-4R- classically M1 macrophages. GR1+ cells also express mannose (CD206), caspase-1, IL-1β IL-10. In gonadectomized male mice, significantly more...
Abstract Current research has shown heart disease as the leading killer in US. Autoimmune myocarditis (AM) progresses to dilated cardiomyopathy (DCM) and occurs at a higher incidence males. In order study sex differences AM we inoculated BALB/c mice with 103 PFU of coxsackievirus B3 cardiac myosin ip induce autoimmunity. At d10 post infection males develop severe that DCM d35. We investigated functional endpoints by echocardiography d90 found developed significantly more DCM. To investigate...
The systemic inflammatory response (SIRS) underlies the majority of intensive care-related conditions. Depending on origin it may become a governing force organ dysfunctions. immune therefore be contemptuous reaction. While necessary for viral, or bacterial elimination, clearance debris, and regeneration, when dysregulated, overpowering, chronically ongoing, lead to significant collateral damage, failure, autoimmunity. Understanding in specific complex situations, monitoring, targeted...
During the past decades, populous expansion in mast cell scientific literature came forth with more, than forty-four thousand PubMed publications available to date. Such surge is due appreciation of momentous role cells evolution species, development and maintenance vital physiological functions, such as reproduction, homeostasis, fluids, diverse immunological roles, potential far-reaching effects despite minute numbers. While emerging knowledge importance equilibrium comes age when looking...