A5022253457- Carbohydrate Chemistry and Synthesis
- Galectins and Cancer Biology
- Glycosylation and Glycoproteins Research
- Systemic Sclerosis and Related Diseases
- Dermatologic Treatments and Research
- Oil Palm Production and Sustainability
- Agriculture and Rural Development Research
- Hair Growth and Disorders
- Autoimmune Bullous Skin Diseases
- African Botany and Ecology Studies
Institut Cochin
2016-2020
Université Paris Cité
2019-2020
Inserm
2016-2020
Centre National de la Recherche Scientifique
2019-2020
Sorbonne Paris Cité
2019
Abstract Glycosylation with O-linked β-N-acetylglucosamine (O-GlcNAcylation) is a reversible posttranslational modification that regulates the activity of intracellular proteins according to glucose availability and its metabolism through hexosamine biosynthesis pathway. This has been involved in regulation various immune cell types, including macrophages. However, little known concerning mechanisms regulate protein O-GlcNAcylation level these cells. In present work, we demonstrate LPS...
Abstract O-GlcNAc glycosylation is a reversible post-translational modification that regulates the activity of intracellular proteins according to glucose availability and its metabolism through hexosamine biosynthesis pathway (HBP). This has been involved in regulation various immune cell types, including macrophages. However, little known concerning mechanisms regulate protein O-GlcNAcylation level these cells. In present work, we demonstrate LPS treatment induces marked increase RAW264.7...
<h3>Background</h3> Systemic sclerosis (SSc) primarily affects postmenopausal women. This sex bias could partly be explained by the action of estrogens on immune system and/or fibrogenesis. Since little is known about their direct role in <h3>Objectives</h3> Our aim was to evaluate effects i) pathological activation dermal fibroblasts induced transforming growth factor-b (TGF-β) and ii) development experimental fibrosis. <h3>Methods</h3> Effects estrogen inhibition gene inactivation...