A5063532700- Covalent Organic Framework Applications
- Glycosylation and Glycoproteins Research
- Proteoglycans and glycosaminoglycans research
- Metal-Organic Frameworks: Synthesis and Applications
- Galectins and Cancer Biology
- SARS-CoV-2 detection and testing
- Nanoplatforms for cancer theranostics
- Biosensors and Analytical Detection
- Carbohydrate Chemistry and Synthesis
- Cancer-related gene regulation
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- Alzheimer's disease research and treatments
- Bioactive Compounds and Antitumor Agents
- Osteoarthritis Treatment and Mechanisms
- Sleep and Wakefulness Research
- T-cell and Retrovirus Studies
- Sleep and Work-Related Fatigue
- Endoplasmic Reticulum Stress and Disease
- Antibiotic Use and Resistance
- Autophagy in Disease and Therapy
- Protein Tyrosine Phosphatases
- Cytokine Signaling Pathways and Interactions
- Electrohydrodynamics and Fluid Dynamics
New York University
2020-2025
New York University Abu Dhabi
2020-2025
Institut Cochin
2017-2020
Inserm
2017-2020
Université Paris Cité
2017-2020
Centre National de la Recherche Scientifique
2012-2020
McGill University
2018
Ingénierie Moléculaire et Physiopathologie Articulaire
2018
Délégation Paris 5
2017
Sorbonne Paris Cité
2017
A major challenge in controlling the COVID-19 pandemic is high false-negative rate of commonly used RT-PCR methods for SARS-CoV-2 detection clinical samples. Accurate particularly challenging samples with low viral loads that are below limit (LoD) standard one- or two-step methods. In this study, we implemented a three-step approach and quantification employs reverse transcription, targeted cDNA preamplification, nano-scale qPCR based on commercially available microfluidic chip. Using...
With diabetes being the 7th leading cause of death worldwide, overcoming issues limiting oral administration insulin is global significance. The development imine-linked-covalent organic framework (nCOF) nanoparticles for delivery to overcome these barriers herein reported. A gastro-resistant nCOF was prepared from layered nanosheets with loaded between nanosheet layers. insulin-loaded exhibited protection in digestive fluids
Cryosurgery represents a transformative approach in the treatment of resistant tumors, utilizing extreme cold to selectively ablate malignant tissue. However, clinical success this technique is constrained by limited ability current imaging techniques differentiate effectively between cancerous and healthy tissues with high spatial resolution. To overcome challenge, we present nanoscale Covalent Organic Framework, nTG-DFP-COF, specifically designed enhance fluorescence-guided cryo-imaging....
Membrane technology plays a central role in advancing separation processes, particularly water treatment. Covalent organic frameworks (COFs) have transformative potential this field due to their adjustable structures and robustness. However, conventional COF membrane synthesis methods are often associated with challenges, such as time-consuming processes limited control over surface properties. Our study demonstrates rapid, microwave-assisted method synthesize self-standing membranes within...
Cancer cells sustain rapid growth by reprogramming their metabolism to depend heavily on glycolysis, enhanced insulin signaling, and adaptive changes in the unfolded protein response (UPR). Insulin Potentiation Therapy (IPT) enhances chemotherapy efficacy increasing receptor expression, which turn improves uptake of chemotherapeutic agents. Meanwhile, targeting endoplasmic reticulum (ER) stress disrupts protein-folding machinery within cancer cells, steering them toward apoptosis. However,...
The viral Tax oncoprotein plays a key role in both Human T-cell lymphotropic virus type 1 (HTLV-1)-replication and HTLV-1-associated pathologies, notably adult leukemia. governs the transcription from 5'LTR, enhancing thereby its own expression, via recruitment of dimers phosphorylated CREB to cAMP-response elements located within U3 region (vCRE). In addition phosphorylation, is also target O-GlcNAcylation, another reversible post-translational modification involved wide range diseases,...
Abstract Glycosylation with O-linked β-N-acetylglucosamine (O-GlcNAcylation) is a reversible posttranslational modification that regulates the activity of intracellular proteins according to glucose availability and its metabolism through hexosamine biosynthesis pathway. This has been involved in regulation various immune cell types, including macrophages. However, little known concerning mechanisms regulate protein O-GlcNAcylation level these cells. In present work, we demonstrate LPS...
The cytotoxic self-aggregation of β-amyloid (Aβ) peptide and islet amyloid polypeptide (IAPP) is implicated in the pathogenesis Alzheimer's disease (AD) Type 2 diabetes (T2D), respectively. Increasing evidence, particularly co-deposition Aβ IAPP both brain pancreatic tissues, suggests that cross-interaction may be responsible for a pathological link between AD T2D. Here, we examined nature IAPP-Aβ40 co-aggregation its inhibition by small molecules. In specific, characterized kinetic...
Protein and DNA methylation is involved in various biological functions such as signal transmission, repair, gene expression. Abnormal regulation of methyltransferases has been linked to multiple types cancer, but its link autophagy carcinogenesis breast lung cancer not fully understood. We utilized UALCAN, a web tool, investigate database from The Cancer Genome Atlas. found that 17 are upregulated and/or cancer. investigated the effect inhibition on two cell lines (MDA-MB-231 MCF-7) (H292...
Abstract Pregnenolone sulfate is a steroid metabolite of the steroidogenesis precursor, pregnenolone, with similar functional properties, including immunosuppression. We recently reported an elevation in serum levels pregnenolone children malaria, contributing to immunosuppressed state. Yet, molecular mechanisms which this exerts its immunoregulatory functions are lacking. In study, we examined effects on T cell viability, proliferation and transcriptome. observed dose-dependent induction...
This study presents the use of nanoscale covalent organic frameworks (nCOFs) conjugated with tumor-targeting peptides for targeted therapy triple-negative breast cancer (TNBC). While have previously been used delivery, their conjugation COFs represents an innovative approach in this field. In particular, we developed alkyne-functionalized nCOFs chemically modified cyclic RGD (Alkyn-nCOF-cRGD). configuration is designed to specifically target α
Abstract Background A major challenge in controlling the COVID-19 pandemic is high false-negative rate of commonly used standard RT-PCR methods for SARS-CoV-2 detection clinical samples. Accurate particularly challenging samples with low viral loads that are below limit (LoD) one- or two-step methods. Methods We implement a three-step approach and quantification employs reverse transcription, targeted cDNA preamplification nano-scale qPCR based on Fluidigm 192.24 microfluidic chip. validate...
Abstract Objectives Over the past few decades, accumulation of expired and unused medications in households has become a concern. Most people are unaware how to properly dispose and/or medicines. Our objective was inspect extent within Arab United Emirates (UAE), determine which therapeutic groups yield greater amounts medications, evaluate drugs’ disposal practices. Methods This descriptive study written accordance with STROBE (Strengthening Reporting Observational Studies Epidemiology)...
An AMP-derived short 15-mer peptide and its cyclic derivatives have low micromolar broad spectrum antibacterial activity, with rapid onset of bactericidal effect a membrane-targeting mode action.
Objective: To examine whether self-reported sleep duration and visual impairment were associated among College students. Participants: Students (n = 1002, age 17-35 years) from Lebanon the United Arab Emirates. Methods: asked to complete a validated questionnaire between October 2018 May 2019. The questions related sociodemographics, lifestyle characteristics, status, sleeping pattern, mobile-phone use chronic conditions. Results: 18.3% of respondents reported suffer impairment. Among them,...
Despite available treatments, breast cancer is the leading cause of cancer-related death. Knowing that tyrosine phosphatase SHP2 a regulator in tumorigenesis, developing inhibitors cells crucial. Our study investigated effects new compounds, purchased from NSC, on activity and modulation cell lines' proliferation viability. A combined ligand-based structure-based virtual screening protocol was validated, then performed, against active site. Top ranked compounds were tested via enzymatic...
Abstract O-GlcNAc glycosylation is a reversible post-translational modification that regulates the activity of intracellular proteins according to glucose availability and its metabolism through hexosamine biosynthesis pathway (HBP). This has been involved in regulation various immune cell types, including macrophages. However, little known concerning mechanisms regulate protein O-GlcNAcylation level these cells. In present work, we demonstrate LPS treatment induces marked increase RAW264.7...
L'émergence virale résulte de mécanismes complexes qui déterminent la capacité d'un virus à se maintenir dans ses principales espèces hôtes, être transmis en série une nouvelle espèce hôte et initier un processus pathologique responsable maladie.De ce point vue, les lyssavirus (famille des Rhabdoviridae), agents responsables rage, encéphalomyélite aiguë presque invariablement mortelle chez l'homme, représentent cadre d'étude pour examiner relation entre diversité génétique du virus, facteurs...