A5042739808- Genomics and Chromatin Dynamics
- Trace Elements in Health
- Maternal and Perinatal Health Interventions
- Opioid Use Disorder Treatment
- Pain Management and Opioid Use
- Bacillus and Francisella bacterial research
- Maternal and fetal healthcare
- Reproductive Health and Contraception
- Anesthesia and Pain Management
- Yersinia bacterium, plague, ectoparasites research
- Heat shock proteins research
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
University of Michigan–Ann Arbor
2021
University of California, Los Angeles
2018-2020
Williams College
2017
RELX Group (United States)
2012
RELX Group (United Kingdom)
2012
University of Pittsburgh
2011
Enzymatic activity of histones Eukaryotic serve as structural elements to package DNA. However, they contain a copper-binding site for which the biological relevance is unknown. Copper homeostasis critical several fundamental eukaryotic processes, including mitochondrial respiration. Attar et al. hypothesized that may play role in cellular copper utilization (see Perspective by Rudolph and Luger). Using multifaceted approach ranging from vitro biochemistry vivo genetic molecular analyses,...
To address the growing need for new antimicrobial agents, we explored whether inhibition of bacterial signaling machinery could inhibit growth. Because bacteria rely on two-component systems to respond environmental changes, and because these are both highly conserved mediated by histidine kinases, inhibiting kinases may provide broad spectrum activity. The kinase ATP binding domain is with ATPase eukaryotic Hsp90 molecular chaperones. find a chemical scaffold compounds that target leveraged...
Abstract Ancestral histones were present in organisms with small genomes, no nucleus, and little evidence for epigenetic regulation, suggesting may have additional older functions. We report that the histone H3-H4 tetramer is an enzyme catalyzes reduction of Cu 2+ to 1+ when assembled vitro from recombinant histones. Mutations residues putative active site at interface apposing H3 proteins alter enzymatic activity cellular processes such as Sod1 function or mitochondrial respiration depend...
Objective: This study was designed to test the hypothesis that patients prescribed hydrocodone consume a similar number of tablets as those oxycodone after surgery. Summary Background Data: In October 2017, Michigan Opioid Prescribing Engagement Network released opioid prescribing guidelines for surgeries. For each procedure, these recommended 50% more than adjust potency differences. These were simplified in January 2019 recommend same 5 mg procedure. Methods: Retrospective, observational...