Optical orbital angular momentum (OAM) has been recently implemented in holography technologies as an independent degree of freedom for boosting information capacity. However, the capacity and fidelity suffer from limited space-bandwidth product (SBP) channel crosstalk, albeit OAM mode set exploited multiplexing channels is theoretically unbounded. Here, we propose ultra-dense perfect holography, which modes are discriminated both radially angularly. As such, constructs two-dimensional...

Abstract Supply–demand analysis is an important part of the planning urban emergency shelters. Using Pudong New Area, Shanghai, China as example, this study estimated daytime and nighttime population area based on fine-scale land use data, census statistical yearbook information, Tencent user-density big data. An exponential function-based, probability density estimation method was used to analyze spatial supply demand for shelters under earthquake scenario. The results show that even if all...

A method employing femtosecond lasers to inscribe helical long period fiber grating (HLPFG) for exciting orbital angular momentum (OAM) of light is experimentally demonstrated. In this method, the refractive index modulation (RIM) HLPFG realized by three-dimensional translation a without rotation, indicating better stability, repeatability and flexibility. The coupling efficiency can be customized varying radius RIM, except laser energy. characteristics phase polarization purity coupled...

The purpose of this study is to develop a radiomics approach predict brain metastasis (BM) for stage III/IV ALK-positive non-small cell lung cancer (NSCLC) patients.Patients with NSCLC from 2014 2017 were enrolled retrospectively. Their pretreatment thoracic CT images collected, and the gross tumor volume (GTV) was defined by two experienced radiation oncologists. An in-house feature extraction code-set performed based on MATLAB 2015b (Mathworks, Natick, MA, USA) in patients' extract...

Background: The aim of this study was to develop and validate reliable nomograms predict individual overall survival (OS) cancer-specific (CSS) for patients with primary tracheal tumors further estimate the role postoperative radiotherapy (PORT) these entities. Patients methods: A total 405 eligible diagnosed between 1988 2015 were selected from Surveillance, Epidemiology, End Results database. All them randomly divided into training (n=303) validation (n=102) sets. For purpose establishing...

Abstract Purpose This study aimed to evaluate the clinical relevance of exosomal HER2 (Exo HER2) level in assessing tissue status and predicting efficacy trastuzumab treatment. Methods In this prospective study, patients with advanced gastric cancer (AGC) from three hospitals between August 2016 November 2020 were enrolled. The Exo was detected by enzyme‐linked immunosorbent assay. Receiver operating characteristic curve (ROC) drawn referring assess diagnostic value HER2. Cox proportional...

Background The prognostic value of surgery and postoperative radiotherapy (PORT) for primary thymic neuroendocrine tumors (TNETs) was estimated using the SEER database. Methods This retrospective study used data TNET patients between 1998 2015. Propensity score matching (PSM) performed according to whether performed. effects on overall survival (OS) cancer‐specific (CSS) were evaluated multivariate Cox regression. Results A total 3947 included: 293 (7.4%) TNET, 2788 (70.6%) thymoma, 866...

A class of ultra-short chiral long period fiber gratings (CLPFGs) are prepared by writing a spiral curve on the surface six-mode fiber. The CLPFGs applied to excite ±2nd- and ±3rd-order orbital angular momentum (OAM) modes. coupling efficiency CLPFG in these modes can be as high 99%, when length is only 0.5cm. polarization characteristic excited higher-order OAM was theoretically analyzed experimentally investigated. Results show that obtained independent, expected.

Lower thoracic esophageal cancer (LTEC) with celiac node metastasis and upper (UTEC) supraclavicular were previously categorized as M1a diseases. Our study aimed to investigate whether the clinical significance of lymph should be reevaluated in cancer.A total 6178 patients identified from Surveillance, Epidemiology, End Results (SEER) database during 2004-2015. Treatment strategies outcomes (OS, overall survival; CSS, cancer-specific survival) different nodal status reviewed. The Cox...

Immunotherapy has greatly increased the survival time of patients with extensive-stage small cell lung cancer (ES-SCLC), and is now a standard first-line treatment for these patients. Increasing evidence suggests possible synergistic effect between immunotherapy radiotherapy, yet there paucity regarding efficacy safety thoracic radiotherapy (TRT) combined chemo-immunotherapy ES-SCLC.The medical records 78 consecutive ES-SCLC who received TRT in combination at Jinling Hospital Jiangsu Cancer...

In this Letter, a method for orbital angular momentum (OAM) mode generation is proposed and experimentally demonstrated using fiber Bragg grating (FBG) off-axis incidence. The FBG fabricated by femtosecond laser was used to couple the incidence beam into backward high-order modes. generated modes were then reformed ring-shaped OAM adjusting displacement of input beam. intensity distribution, phase vortex, purity output light investigated. Results indicates that order dependent on resonant...

Background: We aim to assess the prognostic ability of three common lymph node–based staging algorithms, namely, number positive nodes (pN), node ratio (LNR), and log odds (LODDS) in patients with esophageal squamous cell carcinoma (ESCC). Methods: A total 3902 ESCC treated at 10 Chinese institutions between 2003 2013 were included, along 2465 from Surveillance, Epidemiology, End Results (SEER) database. The aforementioned algorithms was evaluated using time-dependent receiver operating...

This article focuses on the 'small moments' of digitally mediated mobilities in mundane. Drawing a qualitative GIS analysis people's walking, driving and ride-hailing urban Guangzhou (a megacity south China), this maps complex dynamic anxieties from social practice perspective. It argues that daily are entangled with digital practices reducing, removing or producing future uncertainties, as well those generating instant confusion digital/data during management organisation familiar routines....

Nowadays, discovering new skeleton antifungal drugs is the direct way to address clinical fungal infections. Pyrylium salt SM21 was screened from a library containing 50,240 small molecules. Several studies about activity and mechanism of have been reported, but structure-activity relationship pyrylium salts not clear. To explore chemical space SM21, series derivatives were designed synthesized. Their relationships (SAR) investigated. Compared with most synthesized compounds exhibited...

We designed and built Bubble Beats, a breathing exercise game based on music rhythm, which maps into musical gameplay mechanics using sensors-based technology. Beats aims to explore the effectiveness of combining rhythm exercises. In game, children blow bubbles with visual guidance. Initial user tests show that can effectively motivate improve their adherence will continue iterate upgrade system attract match more diverse population, for example, patients recovering from pneumonia other...

A tunable mode convertor is experimentally demonstrated based on a fiber Bragg grating (FBG), which fabricated in graded-index nine-mode by using femtosecond laser. Nine linearly polarized (LP) modes were excited and the coupling efficiency of them can reach 90%. By adjusting polarization controller, ±1st-, ±2nd-, ±3rd-, ±4th-order orbital angular momentum (OAM) excited, means OAM tuning 0-±1ℏ, 0-±2ℏ, 0-±3ℏ, 0-±4ℏ achieved. LP21/LP02, LP31/LP12, LP41/LP22/LP03 successfully tuned at 1556.00...

Studies have shown that the incidence and severity of corona virus disease 2019 (COVID-19) in patients with lung cancer are higher than those healthy people. At present, main anti-tumor treatments for include surgery, immunotherapy, chemotherapy, radiotherapy, targeted therapy anti-angiogenesis therapy. While effects different on occurrence COVID-19 pneumonia not uniform. Therefore, we aimed to describe clinical characteristics antitumor pneumonia, examined risk factors this population.From...

BACKGROUND The aim of this study was to investigate the protective effects neutrophil gelatinase-associated lipocalin (NGAL) on hypoxia/reoxygenation (H/R) induced acute kidney injury (AKI) in vitro. MATERIAL AND METHODS We used NRK-52E cells and H/R treatments mimic ischemia/reperfusion (IRI) Experimental groups were: control group, 3-methyladenine (3-MA)+H/R NGAL (0.25, 0.5, 1 ug/mL)+H/R ug/mL)+3-MA+H/R group. After 24 hours culture, cell proliferation analyzed by CCK-8 assay. Expression...

We experimentally demonstrated an all-fiber reflective orbital angular momentum (OAM) generator based on orthogonal fiber Bragg grating (OFBG). The OFBG is formed by using a femtosecond laser to prepare two gratings with certain spacing in planes. ±1st- and ±2nd-order OAM modes were directly excited this OFBG, the chirality of depends relative positions FBGs. mode coupling properties effects center-to-center distance investigated as well.

Objective: Recent investigations have proposed a link between gut microbiomes (GMs) and various cancers, yet the involvement of GMs in vulvar cancer (VC) remains unclear. The objective this study was to discover causal association VC identify GM taxa with potential effect. Methods: Utilizing Mendelian randomization (MR) genome-wide (GWAS) summary statistics, we analyzed 211 190 cases 167,189 healthy controls. main analysis used inverse-variance weighted (IVW) approach, complemented by median...

This article presents the design and practice of a field course program that combines urban walking tradition digitally enabled mobile learning. adopts concept flâneur/flâneuse to develop peripatetic pedagogy aiming cultivate students' assisted ethnographic skills; assist students in writing digitally-mediated post-modern city creatively. Based on collaborative analysis, this can offer creative critical way thinking about our bodies, positionings, entanglements technologies multi-media...

ABSTRACT Objective Stereotactic ablative radiotherapy (SABR) is renowned for its high local control (LC) rates. Nonetheless, tumors that are either large in volume or close proximity to critical organs at risk, the application of SABR entire tumor becomes impractical. This study aims evaluate efficacy and safety partial boost before conventional (P‐SABR) treatment (> 5 cm) unresectable stage III nonsmall cell lung cancer (NSCLC). Methods From April 2014 January 2024, 44 patients with >...

Abstract: Echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion occurs in approximately 5% of non-small cell lung cancer (NSCLC) cases. Variants 1 and 3a/b are the most common EML4-ALK variants. Emerging evidence indicates that patients with variant those exhibit differential therapeutic responses. However, National Comprehensive Cancer Network guidelines have not included subtype treatment decision-making to date. Herein, we report case a...