The Preserflo MicroShunt represents a novel glaucoma treatment device, necessitating long-term follow-up data to accurately assess its efficacy. aim of this study is report real-world heterogenous cohort who received implantation at specialized clinic. A total 160 eyes patients underwent were retrospectively enrolled in study. Patient characteristics, as well success and failure rates, assessed. numbers adverse events revision procedures recorded, along with any reduction supplementary...

Background: The aim of this study was to evaluate the effects Preserflo implantation on endothelial cell density (ECD), corneal thickness, intraocular pressure (IOP), and use antiglaucoma medications over a 12-month follow-up period. Methods: A total 53 eyes from patients undergoing were included in prospective study. ECD, IOP, number measured at baseline, 3 months, 12 months postoperatively. Statistical analysis performed using paired t-tests Wilcoxon signed-rank tests for non-normally...

Background/Objectives: To compare the efficacy and safety of Hydrus® Microstent iStent inject® W implants, in combination with phacoemulsification, for lowering intraocular pressure (IOP) patients glaucoma a real-world clinical setting. Methods: This retrospective, single-center study analyzed medical records who underwent either or implantation combined cataract surgery at University Hospital Muenster, Germany. Key outcome measures included absolute relative IOP reduction, reduction topical...

Abstract Purpose To evaluate the retinal microvascular density using optical coherence tomography angiography (OCTA) in patients with systemic lupus erythematosus (SLE) treated hydroxychloroquine (HCQ). Methods Nineteen eyes of 19 SLE (study group) without HCQ retinopathy and healthy subjects (control were included this study. The study group was divided into for > 5 years (high-risk < (low-risk group). VD data 3 × mm OCT angiogram superficial capillary plexus (SCP) choriocapillaris...

The WW-and-C2-domain-containing (WWC) protein family is involved in the regulation of cell differentiation, proliferation, and organ growth control. As upstream components Hippo signaling pathway, WWC proteins activate Large tumor suppressor (LATS) kinase that turn phosphorylates Yes-associated (YAP) its paralog Transcriptional coactivator-with-PDZ-binding motif (TAZ) preventing their nuclear import transcriptional activity. Inhibition expression leads to downregulation increased YAP/TAZ...

To evaluate the effect of topical mydriatic eye drops on optical coherence tomography angiography (OCTA) parameters in patients with age-related macular degeneration (AMD).27 eyes 27 suffering from AMD were included this cross-sectional study. Patients ≥-4.5 diopters spherical equivalent, corneal opacities or dense cataract preventing high-quality imaging excluded. Whole-en-face scans superficial capillary plexus (SCP) and deep (DCP) central 3x3mm foveal region as well whole-en-face...

Background/Aims To analyse the distribution of macular ganglion cell layer thickness (GCLT) in patients with foveal hypoplasia (FH) or without albinism to obtain new insights into visual pathway anomalies albinos. Methods Patients FH who presented at our institution between 2013 and 2018 were retrospectively drawn for analysis. Mean GCLT was calculated after automated segmentation spectral domain-optical coherence tomography (SD-OCT) scans. due (n = 13, termed 'albinism FH') other kinds 10,...

Zusammenfassung Hintergrund Ziel der Studie war die Analyse des Stellenwertes von „eLearning“ im Lern- und Fortbildungsverhalten Augenärzten in Deutschland sowie Bewertung Akzeptanz einer neuen „eLearning“-Anwendersoftware (App). Material Methoden Ophthalmologische Weiterbildungsassistenten Fachärzte wurden Rahmen Fortbildungsveranstaltungen mittels eines Fragebogens nach ihren Fortbildungsaktivitäten befragt. Des Weiteren erfolgte Vorstellung Anwendung „eLearning-App“ eine strukturierte...

Dacryocystorhinostomy (DCR) remains the gold standard therapy for nasolacrimal duct obstruction (NLDO), but is invasive and does not maintain physiology of lacrimal pathway. With transcanlicular microdrill dacryoplasty (MDP), there a minimally alternative surgical approach. This study aimed to present this modern surgery technique evaluate its long-term success rate in large population.The medical records 1010 patients with acquired NLDO were retrospectively reviewed. Adult who had undergone...

Purpose: Drug delivery to treat ocular diseases still is a challenge in ophthalmology. One way achieve drug that investigated currently topical administration of drug-loaded polymeric nanoparticles (NPs) are able penetrate barriers. The purpose this study was optimal preparation NPs made from pseudo-proteins and evaluation their ability tissues. Methods: Biodegradable various types were prepared by nanoprecipitation pseudo-protein composed l-leucine (L), 1,6-hexanediol (6), sebacic acid (8)...

<b><i>Objectives:</i></b> To evaluate the knowledge of and attitudes toward postmortem cornea donation in living young elderly potential donors a German city. <b><i>Method:</i></b> High-school students seniors participated nonrandomized prospective survey focusing on willingness to donate corneas factors that might influence underlying specific attitudes. Statistical analysis was descriptive included logistic regression....

It has long been speculated whether the presence of a cilioretinal artery (CRA) can influence development glaucomatous damage in patients with open-angle glaucoma. Studies involving healthy have shown change flow density (FD) depending on CRA. Similarly, studies that compared optical coherence tomography angiography (OCTA) results controls and glaucoma cohorts identified reduction FD certain retinal layers for patients. These observations raise question is altered CRA, possible implications...

Abstract Optical coherence tomography angiography measurements are influenced by a range of environmental factors as blood pressure and physical fitness. The present study aimed to evaluate the effects light dark exposure in eyes with neutral mydriatic pupils on vessel density macular optic nerve head regions, measured using optical (OCTA). 55 healthy volunteers (28 patients pupils; 27.18 ± 4.33 years) were examined high-speed high-resolution spectral-domain OCT XR Avanti system...

Glaucoma is one of the leading causes irreversible blindness globally and characterized by gradual loss retinal ganglion cells. The primary risk factor for development progression glaucoma increased intraocular pressure (IOP). Numerous surgical interventions exist to lower IOP should conservative therapy fail. One trend in recent years has been minimally invasive surgery (MIGS) as an alternative traditional methods. ISTENT inject® ab interno trabecular micro-bypass implant designed be...

We compare the short- and mid-term postoperative outcomes of iStent inject® with its successor, W. A retrospective monocentric study was performed to used for cataract surgery W, also surgery. The primary endpoint intraocular pressure (IOP) reduction six months after Six-month follow-up results were available 35 eyes from 27 patients in group 32 25 W group. IOP at post significantly greater (-2.2 mmHg [iStent W] vs. -0.06 inject®], p = 0.037). There a statistically decrease glaucoma...

The WWC protein family is an upstream regulator of the Hippo signalling pathway that involved in many cellular processes. We examined effect endothelium-specific WWC1 and/or WWC2 knock-out on ocular angiogenesis. Knock-outs were induced C57BL/6 mice at age one day (P1) and evaluated P6 (postnatal mice) or five weeks three months (adult mice). analysed morphology retinal vasculature flat mounts. In addition, vivo imaging functional testing by electroretinography performed adult mice. Adult...

Abstract Background/aim The aim of this paper is to compare retinal nerve fiber layer thickness (RNFL) and Bruch’s membrane opening-based minimum rim width (BMO-MRW) in terms their performance detecting early moderate/advanced glaucoma using receiver operating characteristics (ROC) analysis the classification 5th percentile as a cut-off. Methods One hundred eyes from 100 patients with (mean deviation (MD): < -5.0 dB) (MD: > were carefully matched healthy controls based on optic disc...

AnamneseEine 32-jährige Patientin stellte sich erstmalig bei Zustand nach beidseitiger Stauungspapille zur Zweitmeinung in der Universitätsaugenklinik Münster vor.Anamnestisch sei die im vorherigen Monat aufgrund einer Sinusvenenthrombose hospitalisiert

To investigate macular and peripapillary vascular density (VD) in patients with anorexia nervosa (AN) compared to healthy controls.

Cilioretinal arteries are a common congenital anomaly of retinal blood supply. This paper presents deep learning-based approach for the automated detection CRA from color fundus images. Leveraging Vision Transformer architecture, pre-trained model RETFound was fine-tuned to transfer knowledge broader dataset our specific task. An initial 85 expanded 170 images through data augmentation using self-supervised learning-driven techniques. To address imbalance in and prevent overfitting, Focal...