A5086855408- Inflammatory Myopathies and Dermatomyositis
- Respiratory Support and Mechanisms
- Systemic Sclerosis and Related Diseases
- Immunodeficiency and Autoimmune Disorders
- Dermatologic Treatments and Research
- Mast cells and histamine
- Cardiovascular Effects of Exercise
- Sepsis Diagnosis and Treatment
- Cardiac electrophysiology and arrhythmias
- Intensive Care Unit Cognitive Disorders
- Endoplasmic Reticulum Stress and Disease
- Cardiovascular Function and Risk Factors
- Bone health and treatments
- Autoimmune Neurological Disorders and Treatments
- Genomics, phytochemicals, and oxidative stress
- Extracellular vesicles in disease
- ATP Synthase and ATPases Research
- Cardiovascular Disease and Adiposity
- Obstructive Sleep Apnea Research
- Metabolism, Diabetes, and Cancer
- Immune Cell Function and Interaction
- Renin-Angiotensin System Studies
- HIV-related health complications and treatments
- Muscle Physiology and Disorders
- Signaling Pathways in Disease
University of Manchester
2018-2025
Greater Baltimore Medical Center
2020
Allen Hospital
2013-2014
University of Vermont Medical Center
2013-2014
The University of Texas Health Science Center at Houston
2009-2010
Texas A&M University at Galveston
2005
Sapienza University of Rome
2005
University of Virginia
1999-2003
U.S. National Science Foundation
1999
Background Heart failure with preserved ejection fraction (HFpEF) is linked to prolonged endoplasmic reticulum (ER) stress. P21‐activated kinase 2 (Pak2) facilitates a protective ER stress response. This study explores the mechanism and role of Pak2 in HFpEF pathology. Methods Results The mouse model was established using high‐fat diet combined nitric oxide synthase inhibitor Nω‐Nitro‐ l ‐arginine methyl ester (high‐fat diet+Nω‐Nitro‐ ester). exhibited typical characteristics (cardiac...
To examine the predictive role of HLA genetic markers in scleroderma renal crisis (SRC), beyond known clinical correlates, a large population patients with systemic sclerosis (SSc).SSc from Scleroderma Family Registry and DNA Repository, Genetics versus Environment Outcomes Study, rheumatology division registry at University Texas Health Science Center Houston were included study. Relevant data obtained by chart review, autoantibodies detected utilizing commercially available kits. class II...
Endoplasmic Reticulum (ER) stress and oxidative have been highly implicated in the pathogenesis of cardiac hypertrophy heart failure (HF). However, mechanisms involved interplay between these processes are not fully understood. The present study sought to determine a causative link Pak2-dependent UPR activation via Nrf2 regulation under pathological ER stress. We report that sustained Pak2 deletion cardiomyocytes enhance expression. Conversely, AAV9 mediated delivery leads significant...
Previous studies showed that sensory feedback from the body wall is important and sometimes critical for generating normal, robust swimming activity in leeches. In this paper, we evaluate role of intersegmental coordination using both behavioral physiological measurements. We severed ventral nerve cord leeches midbody then made video situ extracellular recordings animals. Our electrophysiological unequivocally demonstrate active occurs with cords, refuting Schülter’s (1933) earlier...
Estrogen receptor alpha (ERα) degradation is regulated by ubiquitination, but the signaling pathways that modulate ERα turnover are unknown. We found extracellular signal-regulated kinase 7 (ERK7) preferentially enhances destruction of not related androgen receptor. Loss ERK7 was correlated with breast cancer progression, and all ERα-positive tumors had decreased expression compared to in normal tissue. In human cells, a dominant-negative mutant rate endogenous >4-fold presence hormone...
Myocardial insulin resistance contributes to heart failure in response pathological stresses, therefore, a therapeutic strategy maintain cardiac pathways requires further investigation. We demonstrated that receptor substrate 1 (IRS1) was reduced failing mouse hearts post-myocardial infarction (MI) and human hearts. The mice manifesting severe dysfunction post-MI displayed elevated mir128-3p the myocardium. Ischemia-upregulated promoted Irs1 degradation. Using rat cardiomyocytes...
In mammalian ventricles, electrical gradients establish heterogeneities as essential tissue mechanisms to optimize mechanical efficiency and safeguard stability. Electrical shape electrocardiographic patterns; disturbance of is proarrhythmic. The zebrafish heart a popular surrogate model for human cardiac electrophysiology thanks its remarkable recapitulation electrocardiogram ventricular action potential features. Yet, are largely unexplored. goal this study define the that QRS complex T...
Background Prolonged activation of angiotensin II is the main mediator that contributes to development heart diseases, so converting into 1-7 has emerged as a new strategy attenuate detrimental effects II. Prolylcarboxypeptidase lysosomal pro-X carboxypeptidase able cleave at preferential acidic pH optimum. However, insufficient attention been given cardioprotective functions prolylcarboxylpeptidase. Methods and Results We established CRISPR/CRISPR-associated protein 9-mediated global...
The idiopathic inflammatory myopathies (IIM) are rare sporadic disorders with an overall annual incidence of approximately 1 in 100,000 and a higher women. IIM is autoimmune process leading to muscle inflammation due ‘dysfunctional adaptive immune response evidenced by cell-mediated myocytoxicity, high prevalence autoantibodies overexpression Major Histocompatibility (MHC) I II molecules on the sarcolemma’. These processes can be appreciated as infiltrates biopsies. Common clinical findings...
Background: Several parameters have recently been proposed to assess mechanical dyssynchrony using tissue Doppler/strain Doppler imaging (]DI/SRI).Few data ~0(isl regarding the assessment ol inter-and inlra-ventricular in patients after tetralogy Fallot (TOF) repair presence right bundle branch block.Methods: Eleven TOF (aged 17-42 years) with dilated ventricle (NYHA class II or greater), block (QRS >120ms), and RV fractional area change (RVFAC) <20% were studied TDI/SRI echocardiography...
Abstract Introduction Obstructive Sleep Apnea (OSA) has been shown to reduce health-related quality of life and is associated with cardiovascular disease other negative health outcomes. However, many patients suspected OSA are never tested, thereby remaining undiagnosed untreated. In this study, we explore the diagnostic pathways eventual treatment individuals OSA. Methods We conducted a retrospective, observational linking claims prior authorization data large, geographically diverse...
Naovarat, Benjamin S. MD; Lyons, Marka A. MA; Dau, Jonathan D. Nguyen, Binh Y. Salazar, Gloria Williams, Francis M. Reveille, John MDAuthor Information