A5053063752- Cardiac electrophysiology and arrhythmias
- Genomics, phytochemicals, and oxidative stress
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Hematopoietic Stem Cell Transplantation
- Cell death mechanisms and regulation
- Pharmacological Effects of Natural Compounds
- Neuroscience and Neural Engineering
- Tryptophan and brain disorders
- Renal Transplantation Outcomes and Treatments
- Animal and Plant Science Education
- Redox biology and oxidative stress
- Plant-based Medicinal Research
- Toxoplasma gondii Research Studies
- Pharmacological Effects and Toxicity Studies
- Integrated Circuits and Semiconductor Failure Analysis
- Cancer Treatment and Pharmacology
- Pneumocystis jirovecii pneumonia detection and treatment
- RNA Interference and Gene Delivery
- Berberine and alkaloids research
- Metabolism, Diabetes, and Cancer
- Free Radicals and Antioxidants
- Cytomegalovirus and herpesvirus research
- Potassium and Related Disorders
- Advanced Electron Microscopy Techniques and Applications
Post Graduate Institute of Medical Education and Research
2018-2024
Institute of Medical Sciences
2024
M.J.P. Rohilkhand University
2024
Centre for Cellular and Molecular Biology
2024
Council of Scientific and Industrial Research
2024
Banaras Hindu University
2024
University of Arizona
2021-2022
University of Arizona Cancer Center
2021-2022
University of Delhi
2022
Northwestern University
2013-2021
In response to neurotoxic signals, postmitotic neurons make attempts reenter the cell cycle, which results in their death. Although several cycle proteins have been implicated cycle-related neuronal apoptosis (CRNA), molecular mechanisms that underlie this important event are poorly understood. Here, we demonstrate agents such as β-amyloid peptide cause aberrant activation of mitogen-activated kinase (MEK)-extracellular signal-regulated (ERK) signaling, promotes entry into resulting...
Hypokalemia is known to promote ventricular arrhythmias, especially in combination with class III antiarrhythmic drugs like dofetilide. Here, we evaluated the underlying molecular mechanisms.Arrhythmias were recorded isolated rabbit and rat hearts or patch-clamped myocytes exposed hypokalemia (1.0-3.5 mmol/L) absence presence of dofetilide (1 μmol/L). Spontaneous early afterdepolarizations (EADs) tachycardia/fibrillation occurred 50% at 2.7 mmol/L [K] 3.3 its presence. Pretreatment...
Rationale: Heme plays a critical role in gas exchange, mitochondrial energy production, and antioxidant defense cardiovascular system. The transporter ATP-binding cassette (ABC) B10 has been suggested to export heme out of the mitochondria is required for normal hemoglobinization erythropoietic cells protection against ischemia–reperfusion injury heart; however, its primary function not established. Objective: aim this study was identify ABCB10 synthesis cardiac cells. Methods Results:...
Abstract Light-sheet fluorescence microscopy (LSFM) serves to advance developmental research and regenerative medicine. Coupled with the paralleled advances in fluorescence-friendly tissue clearing technique, our cardiac LSFM enables dual-sided illumination rapidly uncover architecture of murine hearts over 10 by mm 3 volume; thereby allowing for localizing progenitor differentiation cardiomyocyte lineage AAV9-mediated expression exogenous transmembrane potassium channels high contrast...
The role of nuclear factor-2 erythroid related (Nrf2) activator, berberine (BBR), has been established in rat model streptozotocin induced diabetic neuropathy. Around 30-40% cancer patients, on paclitaxel (PTX) chemotherapy develop peripheral present study was contemplated with the aim establishing neuropathy preventive BBR, rats.A total 30 Wistar rats were divided into five groups as follows: Group I: dimethyl sulfoxide; II: PTX+ 0.9% NaCl; III: Amitriptyline (ATL) + PTX; IV: BBR (10 mg/kg)...
The treatment of heart failure (HF) is challenging and morbidity mortality are high. goal this study was to determine if inhibition the late Na(+) current with ranolazine during early hypertensive disease might slow or stop progression. Spontaneously rats (aged 7 mo) were subjected echocardiographic then fed either control chow (CON) containing 0.5% (RAN) for 3 mo. Animals restudied, each removed measurements t-tubule organization Ca(2+) transients using confocal microscopy intact heart. RAN...
Transient outward K currents (Ito) have been reported both to suppress and facilitate early afterdepolarizations (EADs) when repolarization reserve is reduced. Here, we used the dynamic clamp technique analyze how Ito accounts for these paradoxical effects on EADs by influencing evolution of during action potential.Isolated patch-clamped rabbit ventricular myocytes were exposed either oxidative stress (H2O2) or hypokalemia induce bradycardia-dependent at a long pacing cycle length 6 s,...
Local and illegal exploitation of wildlife is particularly widespread in highly-populated bio-diverse countries such as India. In countries, illicit utilization practices how these are perceived among local communities commonly not well-documented. Due to a lack data environmental education measures protect ecosystems biodiversity, the extent this appears immense often goes unnoticed. Therefore, 2019, series awareness workshops targeting conservation with focus on monitor lizards (Varanidae)...
Abstract Background Li-Fraumeni syndrome (LFS) is a highly penetrant autosomal dominant cancer predisposition disorder caused by germline TP53 pathogenic variants. Patients with LFS have increased oxidative phosphorylation capacity in skeletal muscle and stress blood. Metformin inhibits phosphorylation, reducing available energy for cell proliferation decreasing production of reactive oxygen species that cause DNA damage. Thus, metformin may provide pharmacologic risk reduction patients LFS,...
BIN1 (amphyphysin-II) is a structural protein involved in T-tubule (TT) formation and phosphatidylinositol-4,5-bisphosphate (PIP2) responsible for localization of to sarcolemma. The goal this study was determine if PIP2-mediated targeting sarcolemma compromised during the development heart failure (HF) TT remodeling. Immunohistochemistry showed co-localization BIN1, Cav1.2, PIP2, phospholipase-Cβ1 (PLCβ1) TTs normal rat human ventricular myocytes. PIP2 levels were reduced spontaneously...
<br><b>OBJECTIVES:</b> Dimethyl sulfoxide (DMSO) is commonly used as a vehicle for many hydrophobic drugs. This study aimed at evaluating the effect of low dose DMSO (0.1%) on Pentylenetetrazole(PTZ) induced neuronal damage in rats. <br><b>MATERIALS AND METHODS:</b> Young male Wistar rats (n = 32) were divided into four groups follows: saline control group, PTZ group (35 mg/kg), and combination (DMSO + PTZ). Animals observed seizure score, latency to develop kindling, percentage animals...