A5032598644- Neural Networks and Applications
- Manufacturing Process and Optimization
- Design Education and Practice
- Fuzzy Logic and Control Systems
- Genomics and Phylogenetic Studies
- Genomic variations and chromosomal abnormalities
- Product Development and Customization
- Semantic Web and Ontologies
- Machine Learning in Bioinformatics
- AI-based Problem Solving and Planning
- Animal Virus Infections Studies
- Bacteriophages and microbial interactions
- Fractal and DNA sequence analysis
- Advanced Proteomics Techniques and Applications
- Ottoman and Turkish Studies
- SARS-CoV-2 and COVID-19 Research
- Multi-Agent Systems and Negotiation
- Genetic Mapping and Diversity in Plants and Animals
- Stock Market Forecasting Methods
- Genetic Associations and Epidemiology
- Renal and Vascular Pathologies
- Crafts, Textile, and Design
- Genomics and Rare Diseases
- Bioinformatics and Genomic Networks
- vaccines and immunoinformatics approaches
Double Helix (United States)
2018-2024
Helix (United States)
2024
University of Hagen
1992-2016
Hewlett-Packard (United States)
2002
Computational Intelligence and Information Systems Lab
1997
GP Forschungsgruppe
1997
The integrase of the phage ΦC31 recombines an attP site in genome with a chromosomal attB its Streptomyces host. We have utilized integrase-mediated reaction to achieve episomal and genomic deletion reporter gene mammalian cells, provide first comparison efficiency other recombinases new assay system. This demonstrated that ΦC31-integrase is significantly enhanced by C‐terminal, but not N-terminal, addition nuclear localization signal becomes comparable widely used Cre/loxP Furthermore, we...
Design and engineering processes are complex inherently parallel. There is a need for framework which allows document management all phases of tasks. The first part the paper presents an introduction into most challenging issues this field. In second case study from area car manufacturing presented in intranet technology used to support design processes.
Clinical Whole Exome Sequencing (WES) offers a high diagnostic yield test by detecting pathogenic variants in all coding genes of the human genome. WES is poised to consolidate multiple genetic tests accurately identifying Copy Number Variation (CNV) events, typically necessitating microarray analyses. However, standard commercial exome kits are limited targeting exon regions, leaving significant gaps coverage between which could hinder comprehensive CNV detection. To replace microarrays,...
Clinical Whole Exome Sequencing (WES) offers a high diagnostic yield test by detecting pathogenic variants in all coding genes of the human genome. WES is poised to consolidate multiple genetic tests accurately identifying Copy Number Variation (CNV) events, typically necessitating microarray analysis. However, standard commercial exome kits are limited targeting exon regions, leaving significant gaps coverage between genes, which could hinder comprehensive CNV detection. To convert calling...
As COVID-19 has spread from its origin in Wuhan, China, into a global pandemic, there been number of efforts to understand the mutations and clusters genetic lineages SARS-CoV-2 virus. The high mutation rate rapid makes this analysis capable tracking chains infections as well putting individual sequences context. So far, phylogenetic methods have recently found broader application regard.
Future CAD frameworks for VLSI chip design will provide a component to support the designer in finding applicable strategies and tools deciding which of them are best suited specific task. This paper describes underlying concepts prototype such consulting system. It introduces model process, allows one define where process can take place kind information should be taken into account making an appropriate decision. The problem is tackled from AI point view: decision put general taxonomy...
The complexity and the inherent heterogeneity of real world problems are still one major challenges in computer science. Due to necessity using different data processing technologies general interest hybrid systems is a fast growing research area. To support integration intercommunicating hybrids paper suggests use distributed software architectures. main advantages approach presented encapsulation paradigms, separation control domain knowledge reduction individual problem solvers. first...
Gunther, O. P.1; Ng, R.2; Balshaw, R.3; Lin, D.4; Scherer, A.5; Chen, V.2; Cohen-Freue, G.2; Takhar, M.2; Hollander, Z.2; McMaster, McManus, B.6; Keown, P.3 Author Information
The database area has been one of those areas computer science which have very directly driven by application requirements; this is true today in three ways: First, the users want more specific support from database, and they expect DBMS to semantic knowledge. Second, for new applications are sometimes far traditional introduce completely requirements as well need smoothly integrate technology with other advanced technologies (e.g. neural nets) application. Finally, embedding databases into...
As COVID-19 has spread from the first reported cases into a global pandemic, there been number of efforts to understand mutations and clusters genetic lineages SARS-CoV-2 virus. The high mutation rate rapid makes this analysis capable tracking chains infections as well putting individual sequences in context. Whole genomes virus are being collected shared across globe. With advent affordable prolific Next Generation Sequencing, is pandemic which genomic evolution pathogen can be tracked near...
Abstract Since the beginning of global SARS-CoV-2 pandemic, there have been a number efforts to understand mutations and clusters genetic lines virus. Until now, phylogenetic analysis methods used for this purpose. Here we show that Principal Component Analysis (PCA), which is widely in population genetics, can not only help us existing findings about mutation processes virus, but also provide even deeper insights into these while being less sensitive sequencing gaps. describe comprehensive...