A5056297074- SARS-CoV-2 and COVID-19 Research
- Machine Learning in Bioinformatics
- Genomics and Phylogenetic Studies
- Bacteriophages and microbial interactions
- Fractal and DNA sequence analysis
- Veterinary medicine and infectious diseases
- Explainable Artificial Intelligence (XAI)
- Microbial Metabolites in Food Biotechnology
- vaccines and immunoinformatics approaches
- Bacterial Identification and Susceptibility Testing
- Infective Endocarditis Diagnosis and Management
- Animal Virus Infections Studies
- Sepsis Diagnosis and Treatment
- SARS-CoV-2 detection and testing
- Machine Learning in Healthcare
- Helicobacter pylori-related gastroenterology studies
- Antimicrobial Resistance in Staphylococcus
Evangelisches Krankenhaus Bielefeld
2020-2024
Bethel University
2024
Bielefeld University
2021
Genomic surveillance of the SARS-CoV-2 pandemic is crucial and mainly achieved by amplicon sequencing protocols. Overlapping tiled-amplicons are generated to establish contiguous genome sequences, which enable precise resolution infection chains outbreaks. We investigated a outbreak in local hospital used nanopore with modified ARTIC protocol employing 1200 bp long amplicons. detected deletion 168 nucleotides ORF8 gene 76 samples from outbreak. This difficult identify classical procedures...
ABSTRACT Cellular fatty acids of Helicobacter pylori have taxonomic, physiological, and pathogenic implications. However, little is known about the acid composition under various culture conditions. H. usually grown on blood-supplemented complex media, in blood may affect cells. In addition, frequently subcultivated laboratory-adapted strains properties different from those fresh clinical isolates, which are culturable only for a limited number passages. Therefore, cellular profiles (LAS)...
Zusammenfassung Eine gezielte Infektionsdiagnostik liefert Entscheidungshilfen für einen rationalen Antibiotika-Einsatz im Sinne eines Antibiotic Stewardship (ABS). Analog zu ABS wird hierfür der Begriff „Diagnostic Stewardship“ (DGS) vorgeschlagen. DGS bezieht sich neben allgemeinen vor allem auf die mikrobiologische – mit spezifischen Erregernachweisen via Kulturverfahren bzw. Immunologie, zunehmend auch mittels molekularbiologischer Verfahren. Insbesondere in Mikrobiologie spielen...
As COVID-19 has spread from its origin in Wuhan, China, into a global pandemic, there been number of efforts to understand the mutations and clusters genetic lineages SARS-CoV-2 virus. The high mutation rate rapid makes this analysis capable tracking chains infections as well putting individual sequences context. So far, phylogenetic methods have recently found broader application regard.
As COVID-19 has spread from the first reported cases into a global pandemic, there been number of efforts to understand mutations and clusters genetic lineages SARS-CoV-2 virus. The high mutation rate rapid makes this analysis capable tracking chains infections as well putting individual sequences in context. Whole genomes virus are being collected shared across globe. With advent affordable prolific Next Generation Sequencing, is pandemic which genomic evolution pathogen can be tracked near...
Abstract Since the beginning of global SARS-CoV-2 pandemic, there have been a number efforts to understand mutations and clusters genetic lines virus. Until now, phylogenetic analysis methods used for this purpose. Here we show that Principal Component Analysis (PCA), which is widely in population genetics, can not only help us existing findings about mutation processes virus, but also provide even deeper insights into these while being less sensitive sequencing gaps. describe comprehensive...