A5061249362- RNA and protein synthesis mechanisms
- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
- Advanced biosensing and bioanalysis techniques
- Biomedical and Engineering Education
- SARS-CoV-2 detection and testing
- Electrochemical sensors and biosensors
- CRISPR and Genetic Engineering
- Viral gastroenteritis research and epidemiology
- Plant biochemistry and biosynthesis
- Diphtheria, Corynebacterium, and Tetanus
- Animal Disease Management and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Microbial Natural Products and Biosynthesis
- Monoclonal and Polyclonal Antibodies Research
- Chemical Synthesis and Analysis
- Law, AI, and Intellectual Property
- Ethics in Clinical Research
- Neuroscience and Neural Engineering
- Bacillus and Francisella bacterial research
- Mycobacterium research and diagnosis
- Advanced Biosensing Techniques and Applications
- Bacterial Genetics and Biotechnology
- Problem and Project Based Learning
- Viral Infectious Diseases and Gene Expression in Insects
Harvard University
2022-2024
Bielefeld University
2018-2022
University of Cologne
2022
University of Lethbridge
2022
University of Victoria
2022
University of Regina
2022
Public Health Agency of Canada
2022
Colorado State University
2022
Turing Institute
2022
DATA REPORT article Front. Mol. Biosci., 05 July 2018Sec. RNA Volume 5 - 2018 | https://doi.org/10.3389/fmolb.2018.00062
Next generation sequencing (NGS) in combination with phage surface display (PSD) are powerful tools the newly equipped molecular biology toolbox for identification of specific target binding biomolecules. Application PSD led to discovery manifold ligands clinical and material research. However, limitations traditional hinder process. Growth-based library biases target-unrelated peptides often result dominance parasitic sequences collapse diversity. This study describes effective enrichment...
With the rise of synthetic biology, dual-use research risks are not confined to pathogen-related research. However, existing measures mitigate research, such as export control, still designed hinder access pathogens and do address nonpathogen-related The current self-regulatory approach requires scientists be aware their responsibility know how assess establish countermeasures. purpose this study was examine state knowledge about among life science students test an alternative teaching on...
Three novel corynebacterial species were isolated from soil sampled at a paddock in Vilsendorf, North Rhine-Westphalia, Germany. The strains coccoid or irregular rod-shaped, catalase-positive and pale white to yellow-orange colour. By whole genome sequencing comparison of the 16S rRNA genes as well structure, it was shown that all three represent family Corynebacteriaceae, order Corynebacteriales, class Actinobacteria. This project describes isolation, identification, sequencing, phenotypic...
Genomic surveillance of the SARS-CoV-2 pandemic is crucial and mainly achieved by amplicon sequencing protocols. Overlapping tiled-amplicons are generated to establish contiguous genome sequences, which enable precise resolution infection chains outbreaks. We investigated a outbreak in local hospital used nanopore with modified ARTIC protocol employing 1200 bp long amplicons. detected deletion 168 nucleotides ORF8 gene 76 samples from outbreak. This difficult identify classical procedures...
Abstract Removing cellular transfer RNAs (tRNAs), making their cognate codons unreadable, creates a genetic firewall that prevents viral replication and horizontal gene transfer. However, numerous viruses mobile elements encode parts of the translational apparatus, including tRNAs, potentially rendering genetic-code-based ineffective. In this paper, we show such horizontally transferred tRNA genes can enable in Escherichia coli cells despite genome-wide lack three previously essential tRNAs...
Abstract As we enter the era of CRISPR medicines, base editors (BEs) emerged as one most promising tools to treat genetic associated diseases. However, unintended bystander editing beyond target nucleotide poses a challenge their translation into effective therapies. While many efforts have been made in design universal enzyme with minimal editing, context dependent activity represents major for editing-based In this work, designed sequence-specific guide RNA library 3’-extensions and...
To reduce biological risks, raising awareness for dual-use issues already at the level of university education is essential. Currently, most life sciences programs do not incorporate biosecurity and in their regular curricula. Consequently, responsibility rests with individual lecturers depends on initiative to topics into teaching activities. Students interested often only have option educate themselves external or online courses. Here, we provide practical guidance how initiate integrate a...
To address real and perceived emerging risks originating from the ever-accelerating breakthroughs in life science research, Dual Use Research of Concern (DURC) Panel Discussion, organized by Synbio Canada Alberta RNA Training Institute (ARRTI), took place on June 23rd, 2021. It brought together six stakeholders different levels academic administration, governance, publishing to explore current future challenges addressing DURC. Technological advancements within sciences, especially field...