A5002362590- Fungal Infections and Studies
- Herpesvirus Infections and Treatments
- Actinomycetales infections and treatment
- Antifungal resistance and susceptibility
- Hepatitis Viruses Studies and Epidemiology
- Parasites and Host Interactions
- Diagnosis and treatment of tuberculosis
- Mycobacterium research and diagnosis
- Bacterial Identification and Susceptibility Testing
- Nail Diseases and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Infections and bacterial resistance
- Diverticular Disease and Complications
- Heparin-Induced Thrombocytopenia and Thrombosis
- Diphtheria, Corynebacterium, and Tetanus
- Research on Leishmaniasis Studies
- Infection Control and Ventilation
- SARS-CoV-2 and COVID-19 Research
- Streptococcal Infections and Treatments
- Clinical Reasoning and Diagnostic Skills
- Malaria Research and Control
- Travel-related health issues
- Intensive Care Unit Cognitive Disorders
- Phytoplasmas and Hemiptera pathogens
- Pharmaceutical and Antibiotic Environmental Impacts
Stanford University
2025
University of British Columbia
2025
McGill University Health Centre
2019-2025
Vancouver Coastal Health
2025
University of Calgary
2021-2023
Stanford Health Care
2023
McGill University
2019-2021
Jewish General Hospital
2021
Office of Infectious Diseases
2021
Mold plasma cell-free DNA (cfDNA) PCR is a promising non-invasive diagnostic modality for early diagnosis of invasive mold disease (IMD) in immunocompromised patients. Although cfDNA has been shown to be highly accurate, the value procedures collect specimens conventional fungal diagnostics following testing remains unclear. This retrospective single-center cohort study included patients with performed 7 days before or 2 after specimen collection. detected Aspergillus species, Mucorales...
Fluoroquinolones and aminoglycosides are potential treatment choices in the setting of increasingly multi-drug resistant Enterobacterales. The Clinical & Laboratory Standards Institute (CLSI) breakpoints for fluoroquinolones Enterobacterales were revised 2019 2022, respectively. However, performance existing widely used automated systems, such as VITEK 2 AST-N391 card, has not been extensively tested MDR isolates at these new breakpoints. To assess ciprofloxacin, gentamicin, tobramycin on...
Gabapentinoid prescriptions are increasing in North America, with frequent off-label use despite limited proven efficacy. This retrospective cohort study describes prescribing trends among hospitalized patients a focus on dosing and deprescribing. We examined consecutive inpatients between December 2013 July 2017 52-bed medical unit Montréal, Canada. Prevalence of use, median doses prescribed, deprescribing were analyzed over time. Of 4,103 patients, 550 (13.4%) prescribed gabapentinoids...
KEY POINTSA 50-year-old man presented to the emergency department with 3 days of acute severe chest pain that radiated his back, subjective fever and decreased oral intake. He had a history diabetes, hypertension dyslipidemia, for which he was on metformin–sitagliptin, gliclazide,
ABSTRACT Broad-range 16S rRNA PCR and sequencing of 1,183 blood specimens from 853 unique patients yielded an interpretable sequence bacterial identification in 29%, amplification with uninterpretable sequences 53%, no 18%. This study highlights the potential utility this technique identifying fastidious gram-negative anaerobic bacteria but frequent recovery environmental contaminant organisms argues for its judicious use. IMPORTANCE The existing literature focuses on performance compared to...
Bronchoalveolar lavage is usually employed for molecular diagnosis of
Multisystem inflammatory syndrome in adults is a rare and life-threatening complication that follows natural COVID-19 infection primarily affects young unvaccinated adults. This seldom described following vaccination, which would have important implications for the vaccination timing platform this population. vaccines are extremely effective; however, risk of adverse events needs to be balanced with benefits.
In high-income, low-prevalence settings, travel patterns largely govern malaria transmission; the COVID-19 pandemic has led to restrictions resulting in a decrease case incidence. The proportion of travellers seeking pre-travel decreased; with easing borders, an increase cases may occur.
Aims: We characterize the epidemiology of Actinotignum schaalii within a large Canadian region after implementation improved identification methods. Patients & methods: Positive cultures for A. from centralized microbiology laboratory in Canada were analyzed. Clinical data retrieved through administrative databases and chart reviews. Primary outcome was incidence infections; secondary outcomes included mortality, hospital admission length stay. Results conclusions: 86 unique isolates...
A 50-year-old immunocompromised female presented with a 10-day history of fever and dyspnoea. She had recent VFR travel to Vietnam lived in Calgary, Alberta, for 20 years. Investigations revealed bicytopenia, elevated cholestatic enzymes miliary nodular pattern on chest imaging. was diagnosed disseminated fungal infection.
As in other jurisdictions, the demographics of people infected with SARS-CoV-2 changed Quebec over course first COVID-19 pandemic wave, and affected those living residential care facilities (RCFs) disproportionately. We evaluated association between clinical characteristics outcomes hospitalized patients COVID-19, comparing did or not live RCFs.We conducted a retrospective case series all consecutive adults (≥ 18 yr) admitted to Jewish General Hospital Montréal laboratory-confirmed infection...
KEY POINTS A 71-year-old man presented to the emergency department with a 4-month history of weight loss, anorexia and constipation, 2-week abdominal pain. He had biopsy-proven immunoglobulin G4 (IgG4)-related disease involving pancreas kidneys 2 episodes Gram-
Actinotignum schaalii is an underrecognized Gram-positive bacillus due to its special growth requirements and prior phenotypic identification methods, it often mistaken as a contaminant. It has been associated with various clinical syndromes, from urinary tract infections cutaneous infections.
A 71-year-old healthy male presented with a 2-year history of intermittent fever, rigors, and night sweats.These symptoms were associated loss appetite progressive weight 50 lb.He was born in Canada had traveled internationally, including extended periods Germany, more recently spending 6 months per year the Philippines.No rash, lymphadenopathy or organomegaly apparent.His laboratory results remarkable for sodium 129 mmol/L C-reactive protein (CRP) 27.7 mg/L, while his complete blood count...
[Voir la version anglaise de l’article ici: www.cmaj.ca/lookup/doi/10.1503/cmaj.220951][1] Points clésUn homme 50 ans a consulté au service des urgences après 3 jours d’une intense douleur aiguë à poitrine avec irradiation dos, fièvre subjective et inappétence. Il souffrait
Abstract Background Broad-range bacterial PCR sequencing (BRBPS) has emerged as a novel tool to detect fastidious organisms. While its utility been characterized in different specimen types, role culture-negative blood specimens remains poorly understood. Methods We reviewed all clinical sent for BRBPS (blood, serum and culture bottles) the Laboratoire de santé publique du Québec, reference laboratory large Canadian province, from May 2018 November 2022. Sanger of amplified 16s rRNA gene was...
Abstract Background Varicella zoster virus (VZV) hospitalizations are an uncommon, severe and costly consequence of VZV. Childhood VZV vaccination leads to decreased rates across all age groups through herd immunity but increases the acquisition potential risk in non-immune adults. A large proportion (~15%) young adult immigrants from tropical regions susceptible due different transmission dynamics their countries origin lack vaccination. We aimed describe impact childhood program introduced...
Histoplasma capsulatum is an endemic fungus in eastern Canada. This organism has a wide spectrum of manifestations ranging from isolated pulmonary to disseminated disease. The latter usually occurs immunocompromised hosts or those with substantial environmental exposure. In rare instances, histoplasmosis can present as endovascular infection chronic progressive histoplasmosis. If not recognized, these entities are almost uniformly fatal. We report case immunocompetent man history...
Points clés Un homme de 71 ans a consulté aux urgences pour un problème perte poids, d’anorexie et constipation qui durait depuis 4 mois une douleur abdominale 2 semaines. Il était atteint d’une maladie à IgG4 (immunoglobuline G4) confirmée par biopsie
Abstract Background Actinotignum schaalii is a gram-positive rod that fastidious commensal of the urogenital tract. Infections with A. are underdiagnosed previously because phenotypic methods fail to identify it. Both MALDI-TOF mass spectrometry and 16S rRNA sequencing allow definitive identification this opportunistic emerging pathogen. an infrequent but important cause UTIs in elderly, particularly urological abnormalities. The spectrum invasive disease caused by not well characterized;...