<title>Abstract</title> <bold>Background:</bold> Resistance among malaria parasites has emerged against the majority of antimalarial drugs. As a result, development novel therapeutic strategies become increasingly critical. The antisense technique, known for its specificity and minimal resistance toxicity, attracted considerable interest from researchers in recent years. Antisense oligodeoxynucleotides (ASOs) represent promising alternative chemotherapeutic approach inhibiting synthesis...

Degenerative and demyelinating diseases are known to alter the mechanical properties of brain tissue. While few studies have characterized these biomechanical changes, it is clear that accurate characterization diseased tissue could be a substantial asset neuronavigation surgery simulation through haptic devices. In this study, samples from rats infected with Plasmodium berghei ANKA, an African murine malaria parasite, evaluated using uniaxial tensile test machine. Infected brains having...

The following article has been included in a multiple retraction: Karimi A, Navidbakhsh M, Yousefi H, et al. Experimental and numerical study on the mechanical behavior of rat brain tissue. Perfusion 2014;29:307–314, DOI: 10.1177/0267659114522088. In 2015 SAGE became aware author misconduct concerning suspected fabrication identities, as well impersonation legitimate individuals, to manipulate peer review process across three separate journal publications. Editors immediately launched an...

Abstract Polyvinyl alcohol (PVA) sponge with a complex interconnecting porous structure indicates suitable mechanical properties at different strain rates. The paper presents the first scientific study to show how results are given by various definitions of stress–strain used and recommend specific definition when calculating energy absorption characteristics PVA sponge. A series tensile tests on sponges carried out. Three stress (second Piola–Kirchhoff stress, engineering true stress) four...

The skin, being a multi-layered material, is responsible for protecting the human body from mechanical, bacterial, and viral insults. skin tissue may display different mechanical properties according to anatomical locations of body. However, these in regions at loading directions (axial circumferential) mice date have not been determined. In this study, axial circumferential loads were imposed on samples. elastic modulus maximum stress tissues measured before failure occurred. nonlinear...

Skin as an external membrane has a key asset in the human body, i.e. heat balance and protection from peripheral mechanical loads. The properties of skin tissue are almost intricate under various loading conditions that may also differ according to anatomical locations body. Although have been largely studied using different testing methods well material models, time-dependent viscoelastic behavior regions not quantified via Quasi-linear model. In this study, quasi-linear rat back abdomen...

In Iran, Plasmodium vivax is responsible for more than 80% of the infected cases malaria per year. Control interventions in humans rely mainly on developed diagnostic methods. Recombinant P. apical membrane antigen-1 (rPvAMA-1) has been reported to achieve designing rapid, sensitive, and specific molecular diagnosis. This study aimed perform isolation expression a rPvAMA-1, derived from Iranian patients residing an endemic area. Then, efficiency characterized PvAMA-1 was assessed using...

Astrodaucus persicus (Apiaceae) is one of the two species this genus which grows in different parts Iran. Roots plant were rich benzodioxoles and used as food additive or salad Iran near countries. The aim present study was evaluation antimalarial cytotoxic effects fractions A. fruits roots extracts.Ripe extracted fractionated by hexane, chloroform, ethyl acetate methanol, separately. Antimalarial activities performed based on Plasmodium berghei suppressive test mice model percentage...

Anopheles subpictus Grassi is considered a secondary malaria vector in parts of Asia. The current study determined some ecological and bionomical characteristics this species southeastern Iran. temporal patterns abundance, resting behavior, blood feeding activity, host selection, adult susceptibility to insecticides larval habitats were investigated. Most adults collected by pyrethrum space-spray collection, followed pit shelters outlet window traps, respectively. abdominal condition index...

Skin tissue is not only responsible for thermoregulation but also protecting the human body from mechanical, bacterial, and viral insults. The mechanical properties of skin may vary according to anatomical locations in body. However, linear elastic nonlinear hyperelastic different regions at loading directions (axial circumferential) so far have been determined. In this study, during tension rat abdomen back were calculated using material models. samples subjected a series tensile tests....

Malaria parasites cause a tremendous burden of disease in both the tropics and subtropics areas. Growing drugs resistance is one most threats to malaria control. The aim study was investigate anti-malarial activity nano-emodin isolated from Rhamnus cathartica on Plasmodium berghei mice evaluate inhibition rate using in-vivo test.The conducted School Public Health, Tehran University Medical Sciences, during 2020. Nano-emodin particles were prepared cathartica, confirmed by Zeta Potential...

Background: Circumsporozoite protein (CSP) is one of the most important surface sporozoite antigens in malaria, recently considered as a candidate for vaccination. Considering importance CSP, this study was conducted to investigate polymorphism and genetic diversity Plasmodium vivax Protein (Pvcsp) southeastern region Iran during 2015-2016. Methods: To diversity, 20 blood samples were collected from patients with P. vivax, then DNA extracted amplified using partial sequence CSP gene....

The morphology of red blood cells is affected significantly during maturation malaria parasites, Plasmodium falciparum and vivax. A novel shape equation presented that defines parasitized by P. ( Pf-red cells) vivax Pv-red at four stages infection. Giemsa-stained thin films are prepared using samples collected from healthy donors, patients having malaria. diameter thickness plus each stage infection measured their optical images Olysia Scanning Probe Image Processor softwares, respectively....