A5008639269- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Atmospheric chemistry and aerosols
- Air Quality Monitoring and Forecasting
- DNA Repair Mechanisms
- Yersinia bacterium, plague, ectoparasites research
- T-cell and B-cell Immunology
- Pharmacological Effects of Natural Compounds
- Atmospheric and Environmental Gas Dynamics
- Health disparities and outcomes
- NF-κB Signaling Pathways
- Peptidase Inhibition and Analysis
- Trypanosoma species research and implications
- Genomics and Chromatin Dynamics
- Cytomegalovirus and herpesvirus research
- Glycosylation and Glycoproteins Research
- Enzyme Structure and Function
- Enzyme Production and Characterization
- RNA Interference and Gene Delivery
- Viral Infections and Immunology Research
- RNA Research and Splicing
- Bacillus and Francisella bacterial research
- Toxin Mechanisms and Immunotoxins
- Energy, Environment, and Transportation Policies
- Microbial Metabolites in Food Biotechnology
The University of Sydney
2024
Environmental Protection Agency
2016-2023
Research Triangle Park Foundation
2019
Oak Ridge Institute for Science and Education
2016-2017
National Center for Environmental Assessment (EPA)
2016-2017
Duke University Hospital
2014
Duke Medical Center
2014
Duke University
2013
University of Guelph
2013
Southern Methodist University
1991
Gene regulation relies on dynamic changes in three-dimensional chromatin conformation, which are shaped by composite regulatory and architectural elements. However, mechanisms that govern such conformational switches within chromosomal domains remain unknown. We identify a novel mechanism cis-elements promote long-range interactions, inducing critical for diversification of the TCRβ antigen receptor locus (Tcrb). Association between distal Vβ gene segments highly expressed DβJβ clusters,...
Incomplete information regarding emissions from oil and natural gas production has historically made it challenging to characterize the air quality or pollution-related health impacts for this sector in United States. Using an inventory that reflects level distribution of PM2.5 ozone precursor emissions, we simulate annual mean summer season average daily 8 h maximum concentrations with Comprehensive Air-Quality Model extensions (CAMx). We quantify incidence economic value related effects...
We evaluated the sensitivity of estimated PM2.5 and NO2 health impacts to varying key input parameters assumptions including: 1) spatial scale at which are estimated, 2) using either a single concentration-response function (CRF) or racial/ethnic group specific CRFs from same epidemiologic study, 3) assigning exposure residents based on home, instead home work locations for state Colorado. found that analysis influences magnitude NO2, but not PM2.5, attributable deaths. Using county-level...
Policy analysts and researchers often use models to translate expected emissions changes from pollution control policies estimates of air resulting in health impacts. These can include both photochemical Eulerian grid or reduced complexity models; these latter make simplifying assumptions about the emissions-to-air quality relationship as a means reducing computational time needed simulate quality. This manuscript presents new database photochemical- complexity-modelled annual average...
Allelic exclusion requires that the two alleles at antigen-receptor loci attempt to recombine variable (V), diversity (D), and joining (J) gene segments [V(D)J recombination] asynchronously in nuclei of developing lymphocytes. It previously was shown T-cell receptor β (Tcrb) frequently stochastically associate with nuclear lamina pericentromeric heterochromatin CD4(-)CD8(-) thymocytes. Moreover, rearranged were underrepresented these locations. Here we used 3D immunofluorescence situ...
The resection of broken DNA ends is required for double-strand break (DSB) repair by homologous recombination (HR) but can inhibit normal nonhomologous end joining (NHEJ), the main DSB pathway in G1-phase cells. Antigen receptor gene assembly proceeds through intermediates generated lymphocytes RAG endonuclease. These DSBs activate ATM, which phosphorylates H2AX, forming γ-H2AX flanking chromatin. prevents CtIP from initiating DSBs. Whether there are additional proteins to promote these not...
Abstract Next-generation vaccines are required to address the evolving nature of SARS-CoV-2 and protect against emerging pandemic threats from other coronaviruses. These should aim elicit broad-protection, provide long-lasting immunity facilitate equitable access for all populations. In this study, a panel chimeric, full-length spike antigens were developed that incorporate mutations previous, circulating predicted variants. The lead candidate (CoVEXS5) was obtained high-yield production...
Reduced-form modeling approaches are an increasingly popular way to rapidly estimate air quality and human health impacts related changes in pollutant emissions. These reduce computation time by making simplifying assumptions about source characteristics, transport chemistry. Two reduced form tools used the Environmental Protection Agency recent assessments apportionment-based benefit per ton (SA BPT) surfaces (SABAQS). In this work, we apply these two predict ambient summer-season ozone, annual PM
Abstract High salivary amylase activity is associated with improved glycemic homeostasis in humans. Therefore, high greater digestion of starch. However, it unclear if the structures hydrolysates from different individuals are same. To test this, cooked starch (1:2 starch/water ratio) was treated saliva six participants at equal and conditions mimicking oral digestion. Salivary activities ranged 470 × 10 3 to 118 U/mL among participants. The composition characterised by gel‐permeation...
We evaluated the sensitivity of estimated PM2.5 and NO2 health impacts to varying key input parameters assumptions including: 1) spatial scale at which are estimated, 2) using either a single concentration-response function (CRF) or racial/ethnic group specific CRFs from same epidemiologic study, 3) assigning exposure residents based on home, instead home work locations. This analysis was carried out for state Colorado. found that influences magnitude NO2, but not PM2.5, attributable deaths....
Abstract Bubonic plague, caused by the gram-negative bacteria Yersinia pestis, is characterized pathologically swollen lymph nodes (LNs) or buboes. The mechanism which these buboes form and adaptive function they provide for pathogen, if any, remains unknown. We hypothesize that bubo formation a strategy flea-borne Y. pestis to establish foothold in host subsequent systemic infection. Our studies indicate colonization of draining node (DLN) from site infection occurs through trafficking...