A5076759687- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Computational Drug Discovery Methods
- Various Chemistry Research Topics
- Cancer Genomics and Diagnostics
- Genetics, Bioinformatics, and Biomedical Research
- Sex work and related issues
- Cancer therapeutics and mechanisms
- Sepsis Diagnosis and Treatment
- Advanced Proteomics Techniques and Applications
- Chromatin Remodeling and Cancer
- Scientific Computing and Data Management
- Sexuality, Behavior, and Technology
- Cardiac, Anesthesia and Surgical Outcomes
- Gender, Feminism, and Media
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Pharmacogenetics and Drug Metabolism
- Family and Patient Care in Intensive Care Units
- Erythropoietin and Anemia Treatment
- Marketing and Advertising Strategies
- Dialysis and Renal Disease Management
- Respiratory Support and Mechanisms
- Molecular Biology Techniques and Applications
- Single-cell and spatial transcriptomics
The University of Texas MD Anderson Cancer Center
2011-2024
Whitman College
2024
University of Leicester
2020
University of Nevada, Reno
2020
University of Nevada, Las Vegas
2019-2020
Gojo (France)
2019
<ns4:p>Clustered heat maps are the most frequently used graphics for visualization and interpretation of genome-scale molecular profiling data in biology. Construction a map generally requires assistance biostatistician or bioinformatics analyst capable working R similar programming language to transform study data, perform hierarchical clustering, generate map. Our web-based Interactive Heat Map Builder can be by investigators with no experience high-caliber, publication quality maps....
Clustered heat maps are the most frequently used graphics for visualization and interpretation of genome-scale molecular profiling data in biology. Construction a map generally requires assistance biostatistician or bioinformatics analyst capable working R similar programming language to transform study data, perform hierarchical clustering, generate map. Our web-based Interactive Heat Map Builder can be by investigators with no experience high-caliber, publication quality maps. Preparation...
Acute kidney injury (AKI) is a common complication in critically ill patients with cancer. The RIFLE criteria define three levels of AKI based on the percent increase serum creatinine (Scr) from baseline: risk (> or = 50%), 100%), and failure 200% requiring dialysis). utility cancer not known.To examine incidence, outcomes, costs associated cancer.We retrospectively analyzed all admitted to single-center ICU over 13-month period baseline Scr < 1.5 mg/dL (n 2,398). Kaplan-Meier estimates for...
Clustered heatmaps are the most frequently used graphics for visualization of molecular profiling data in biology. However, they generally rendered as static, or only modestly interactive, images. We have now recent advances web technologies to produce interactive "next-generation" clustered (NG-CHM) that enable extreme zooming and navigation without loss resolution. NG-CHMs also provide link-outs additional information sources include other features facilitate deep exploration biology...
The aim was to demonstrate the performance of a modified version Sequential Organ Failure Assessment (SOFA) score predict mortality in medical and surgical patients with cancer. We performed an electronic retrospective review databases. included adult cancer admitted into 53-bed ICU over 28 months. electronically calculated SOFA (mSOFA) at admission. A majority were ICU. Of 328 nonsurvivors, 85.1 per cent only 14.9 patients. mean admission mSOFA scores for 4.7 +/- 3.2 1.7 1.9, respectively....
Reverse-Phase Protein Array (RPPA) is a robust high-throughput, cost-effective platform for quantitatively measuring proteins in biological specimens. However, converting raw RPPA data into normalized, analysis-ready remains challenging task. Here, we present the SPACE (RPPA Superposition Analysis and Concentration Evaluation) R package, substantially improved successor to SuperCurve, meet that challenge. SuperCurve has been used normalize over 170 000 samples date. allows exclusion of...
Abstract Purpose: Despite a growing arsenal of approved drugs, therapeutic resistance remains formidable and, often, insurmountable challenge in cancer treatment. The mechanisms underlying remain largely unresolved thus, examples effective combinatorial or sequential strategies to combat are rare. Here, we present Differential Sensitivity Analysis for Resistant Malignancies (DISARM), novel, integrated drug screen analysis tool designed address this dilemma. Experimental Design: DISARM,...
Lack of attendance to cervical cancer screening (CCS) services is the most attributable factor development cancer. Transgender men, individuals whose gender identity does match with their natal female sex, use CCS less often than general population. The underlying reasons for deficient among transgender men relate mostly stigmatized identity, such as discrimination and unwelcoming healthcare environments. However, additional research needed expand our understanding this complex issue. This...
Previous research on male clients of sex workers has emphasized the diversity purchasing behaviors; however, we know little about how to organize or categorize this quantitatively. I employed latent class analysis with survey data from cisgender primarily female in United States client consumption patterns by type venue used contact and frequency using each venue. found that emerged around context which work is negotiated, generating six distinct buying: generalists, internet-only buyers,...
ABSTRACT Background Principal component analysis (PCA), a standard approach to and visualization of large datasets, is commonly used in biomedical research for detecting similarities differences among groups samples. We initially conventional PCA as tool critical quality control batch trend effects multi-omic profiling data produced by The Cancer Genome Atlas (TCGA) project the NCI. found, however, that visualizations were often hard interpret when inter-batch moderate comparison with...
We evaluated the factors associated with life-supportive therapy withdrawal (LSTW) and length-of-stay (LOS) of adult patients cancer who died while in intensive care unit (ICU). performed chart review a 53-bed ICU comprehensive center relative impact demographic clinical by using logistic regression linear regression. A total 267 were included study. Multivariate analysis showed that white 2.52 times more likely to have LSTW than other ethnicities (95% confidence interval 1.23-5.15, p =...
Objective. To determine the incidence of stress-related mucosal bleeding (SRMB) in a critically ill oncology population receiving stress ulcer prophylaxis (SUP) with either histamine-2 receptor antagonist (H2RA) or proton pump inhibitor (PPI). Design. Single-center, prospective, observational study. Setting. Fifty-two bed medical-surgical intensive care unit an academic institution. Patients. A convenience sample 100 medical and surgical patients who received for more than 24 hours at least...
Complex bioinformatic data analysis workflows involving multiple scripts in different languages can be difficult to consolidate, share and reproduce. An environment that streamlines the entire processes of collection, analysis, visualization reporting such multi-language analyses is currently lacking.We developed Script Scripts (SoS) Notebook, a web-based notebook allows use scripting language single notebook, with flowing freely within across languages. SoS Notebook enables researchers...
In this study, we use a survey of sex workers' clients to examine the relationship between having paid for services in legal brothels Nevada and paying criminalized sexual among male clients. Using ordinary least squares (OLS) generalized ordered logistic regression models, is found be negatively related reported purchasing services, regardless criminal history, income, most other demographic factors. When tested by purchase context, purchases made using Internet, from public, outdoor...
<p>Figure showing the NG-CHM Generator in Galaxy bioinformatics platform.</p>