To reduce the side effects of chemotherapy, nontoxic prodrugs activated by tumor microenvironment are urgently required for use in cancer treatment. In this work, we developed prodrug 4 tumor-targeting treatment and imaging anticancer drug release vivo. Taking advantage high glutathione (GSH) concentration cells, disulfide bond was cleaved, resulting an active a near-infrared (NIR) fluorescence dye turn-on. Furthermore, contrast to free drug, exhibited higher cytotoxicity hepatoma cells than...

Polymeric nanoparticles with glucose-responsiveness under physiological conditions are of great interests in developing drug delivery system for the treatment diabetes. Herein, glucose-responsive complex micelles were prepared by self-assembly a phenylboronic acid-contained block copolymer PEG-b-P(AA-co-APBA) and glycopolymer P(AA-co-AGA) based on covalent complexation between acid glycosyl. The formation P(AA-co-APBA)/P(AA-co-AGA) core PEG shell was confirmed HNMR analysis. investigated...

The gold nanosensors based on the Au-S bond have been widely applied to biochemical detections. However, signal distortion caused by biothiols has seldom mentioned and urgently needs be solved. Herein, we designed a novel but easily assembled nanoprobe coupling selenol-modified peptide with FITC onto nanoparticle's surface via an Au-Se for fluorescence imaging of tumor marker matrix, metalloproteinases 2 (MMP-2). Compared probes, probes display high thermal stability very good...

The discovery that hypobromous acid (HOBr) can regulate the activity of collagen IV has attracted great attention. However, HOBr as an important reactive small molecule hardly ever been studied using a detection method suitable for organisms. Herein, high-quantum-yield mitochondria-targeting near-infrared (NIR) fluorescent probe HOBr, RhSN-mito, was designed. RhSN-mito easily obtained by Suzuki cross-coupling reaction. test results show rapidly respond to with ultrasensitivity and high...

Abstract Bromine has been reported recently as being the 28 th essential element for human health. HOBr, which is generated in vivo from bromide, a required factor formation of sulfilimine crosslinks collagen IV. However, to date, no method specific detection native HOBr reported. Herein, we develop simple small molecular probe imaging based on cyclization catalyzed by HOBr. The can be easily synthesized high yield through Suzuki cross‐coupling reaction. exhibits ultrahigh sensitivity at...

Goals: Hepatocellular carcinoma (HCC) has been reported to be the third most common malignant tumor and highest rate of mortality.To increase chemotherapy efficacy HCC, a drug delivery system featured with desirable active targeting ability, efficiency immune evasion is in high demand.Methods: We have developed nanocarrier by utilizing homotypic cancer cell membrane for targeted HCC.Structurally, HepG2 was used as cloak, poly (lactic-co-glycolic acid) (PLGA) nanoparticle core, resulting...

Resveratrol has been garnering considerable attention as a promising chemopreventive and chemotherapeutic drug against metastatic tumors such triple-negative breast cancer (TNBC). However, the potential in vivo application of resveratrol highly limited due to its poor solubility, rapid conjugation, low bioavailability, bioactivity. In this study, silica mesoporous nanoparticle (MSN)-based delivery system (DDS), named Au–Se@MSN, is developed deliver loaded resveratrol, endowing it with...

The caspase cascade is an ensemble of very important signaling molecules that plays a critical role in cell apoptosis. Real-time monitoring the upstream and downstream activation relationships caspases signal pathway great significance for understanding regulatory mechanisms these development various diseases. Herein, multicolor fluorescent nanoprobe, GNP-Se-Casp, has been developed based on Au-Se bonding real-time situ caspase- (casp-) 3, 8, 9 during In fluorescence imaging apoptotic HeLa...

Identifying cancer at the cellular level during an early stage offers hope of greatly improved outcomes for patients. As potential biomarkers, nitroreductase (NTR) and human quinine oxidoreductase 1 (hNQO1) are overexpressed in many type cells. Simultaneous detection these two biomarkers would benefit diagnostic precision related cancers without yielding false positive results. Herein, based on a dye generated situ strategy, dual-enzyme-responsive probe, CNN, was rationally designed...

An unconventional radical-type migratory insertion mechanism was identified, leading to a distinct cobalt-catalyzed radical-mediated carbon–carbon cleavage for alkylidenecyclopropanes.

Simultaneous fluorescence imaging of selenol and hydrogen peroxide with 5-FAM-peptide-AuNPs QCy7-H₂O₂ was realized during tumor cell apoptosis induced by selenite.

The urban spatial structure is a reflection of development in the dimension, and can have spillover effects on economy, society, environment. As air pollution gradually restricts eco-friendly development, it critical to explore relationship between pollution. This study uses Chinese provinces cities as subjects, selects panel data from 2001 2016 investigate reflected by proportions largest population province municipal districts city. Air measured terms PM2.5, which an inversion...

Digital transformation has emerged as a pivotal catalyst for corporate green innovation, specifically in the context of development manufacturing industry. Nevertheless, it is evident that there are significant disparities various stages digital transformation. Furthermore, precise dynamic capabilities required to propel innovation at distinct this transformation, along with their underlying influencing mechanisms, remain ambiguous. Drawing on capabilities, paper delves into inherent...

The pyranine-induced micellization of poly(ethylene glycol)-block-poly(4-vinylpyridine) (PEG114-b-P4VP61) in aqueous solutions and pH-triggered release pyranine from the complex micelles were studied by dynamic static light scattering, transmission electron microscopy, 1H NMR spectroscopy, UV−vis spectroscopy. At pH 2, ionized can ionically cross-link protonated P4VP block result well-defined spherical with a P4VP/pyranine core surrounded PEG corona. ratio to pyridyl units influence...

Abstract Heteropolyacids and their salts have been effectively used in selective catalytic reduction because of the Keggin structure extraordinarily strong acidity. Catalysts with without were synthesized to further investigate effects heteropolyoxometallate on low temperature NH 3 –SCR. XRD, BET, Raman, H 2 –TPR, –TPD, FT-IR, SO –TPD techniques characterize physicochemical characteristics catalysts. Results indicate that catalysts had more surface Brönsted Lewis acid sites, these...

Tumor recurrence in patients after surgery severely reduces the survival rate of surgical patients. Targeting and killing recurrent tumor cells tissues is extremely important for cancer treatment.

Several unique reactivity patterns of the Ni/JoSPOphos manifold, including facile hydrogen transfer via two-step oxidative addition/migratory insertion and C(sp 2 )–H activation an unconventional σ-CAM mechanism, were disclosed in this work.

Abstract The Cu 0 ‐mediated single electron transfer‐living radical polymerization of acrylamide and N , ‐dimethyl‐ ‐methacryloyloxyethyl‐ ‐sulfobutyl ammonium in aqueous at 25 °C using 2‐chloropropionamide as initiator with powder/tris‐(2‐dimethylamino ethyl)amine (Me 6 ‐TREN) catalyst system is studied. results showed the characteristic “living” that were M n polymers increased linearly monomer conversion ln([M] /[M]) time too, meanwhile narrow molecular weight distributions found most...

Previous studies proposed that sodium selenite (Na2SeO3) was reduced to hydrogen selenide (H2Se) and H2Se subsequently reacted with oxygen generate superoxide anion (O2•–), resulting in tumor cell oxidative stress apoptosis. However, under the hypoxic conditions of a solid tumor, anticancer mechanism remains unclear. To reveal exact real microenvironment, we developed mitochondria-targeting fluorescent nanosensor, Mito-N-D-MSN, which fabricated from mesoporous silica nanoparticles (MSNs)...

When a homo- or bishomoallyllithium, generated by reductive lithiation of the corresponding phenyl thioether radical anion lithium 1-(dimethylamino)naphthalenide (LDMAN), is added to alpha-methylstyrene, tandem addition/cyclization phenyl-substituted five- six-membered-ring occurs. The yields are compromised polymerization process favored tetrahydrofuran (THF), solvent used generate aromatic anions. Thus, new method generating LDMAN (unsuccessful for other common anions) in absence THF has...