Clinical treatment of chronic wounds, particularly those prone to relapse, has been hampered by the regeneration, infection complications, and malignant transformation disordered tissue adhesions. At surface intestinal endothelial, human defensins self-assemble into higher-order nanonets that defend host cells, fight inflammation promote wound healing. Inspired this antimicrobial nanostructured network, we herein attempted construct an nanonet with hemostatic function integrated as dressing....

Five new luminescent metal–organic frameworks (MOFs), [Cd(bdc)(dia)0.5(MeOH)](DMA)0.5 (1), [Cd2O(1,4-ndc)2(dia)2(H2O)]·DMA (2), [Cd(1,4-ndc)(dia)]·MeOH (3), [Cd(bpdc)(dia)0.5]·DMF (4), [Cd(bpdc) (dia)]·DEF (5) (dia = 9,10-bis(1H-imidazol-1-yl)anthracene), were obtained from solvothermal conditions and characterized by PXRD, IR, TG, PL spectra. Single-crystal X-ray diffraction analyses showed that all compounds 1–5 display three-dimensional architectures with diverse topologies. Compound 1...

In order to explore novel colorimetric biosensors with high sensibility and selectivity, two new Keggin polyoxometalates (POMs)-based Cu-trz (1,2,4-triazole) metal-organic frameworks (MOFs) suitable specific surface areas multiple active sites were favorably fabricated; then single-walled carbon nanotubes (SWNTs) merged POMOFs construct POMOF/SWNT nanocomposites. Herein, nanocomposites as peroxidase mimics explored for the first time, peroxidase-mimicking activity of prepared is heavily...

Medium-sized N,S-heterocycles have received tremendous interest due to their biological activities and potential medical applications. However, asymmetric synthesis of these compounds are extremely rare. Described herein is a catalyst-dependent [3,3]-sigmatropic rearrangement sulfoxide-ynamides, enabling divergent atom-economic series valuable medium-sized in moderate good yields with broad substrate scope. Importantly, excellent enantioselectivities been achieved via an unprecedented...

[2,3]-Sigmatropic rearrangement reaction involving sulfonium ylide (Doyle-Kirmse reaction) generated from metal carbenes represents one of the powerful methods for construction C(sp3 )-S and C-C bonds. Although significant advances have been achieved, asymmetric versions via generation ylides rarely reported to date, they so far limited diazo compounds as carbene precursors. Here, we describe a copper-catalyzed enantioselective Doyle-Kirmse azide-ynamide cyclization, leading practical...

The catalytic activity of [CpRu(L)(2)(MeCN)]PF(6) (L = 2-diphenylphosphinopyridine with bulky groups at C-6) for anti-Markovnikov hydration terminal alkynes to aldehydes is retained when one heterocyclic ligand L replaced by L' PPh(3). Equal amounts CpRuCl(PPh(3))(2) (1) and phosphane in acetone solution equilibrate a mixture 1, CpRuCl(L)(PPh(3)) (2), CpRuCl(L)(2) (3), which acts as highly active situ catalyst preparative water-rich media (2 mol % [Ru], 60 °C, 3-18 h 4:1 (v/v)...

Development of multifunctional enzymatic nanomaterials with rapid and sensitive characteristics for glutathione determination is extremely urgent early cancer diagnosis. Herein, a core–shell ultrasensitive nanozyme (denoted as CPT/DM-FA) triple-mode sensing specific in vitro detection constructed. The dendritic mesoporous silica nanoparticle (DMSN) core not only acts camptothecin carrier, but also offers the nanoplatform to synthesize MnO2 shell. Due DMSN-regulated high dispersion MnO2,...

Transition metal/p-block compounds are regarded as the most essential materials for electrochemical energy converting systems involving various electrocatalysis. Understanding role of p-block element on interaction key intermediates and interfacial water molecule orientation at polarized catalyst-electrolyte interface during electrocatalysis is important rational designing advanced modified metal electrocatalysts. Herein, taking a sequence ruthenium phosphides (including Ru

The family of AZARYPHOS (aza-aryl-phosphane) phosphane ligands, containing a phosphine unit and sterically shielded nitrogen lone pairs in the ligand periphery, is introduced as tool for developing ambifunctional catalysis by metal center sphere. General synthetic strategies have been developed to synthesize over 25 examples structurally diverse (6-aryl-2-pyridyl)phosphanes (ARPYPHOS), (6-alkyl-2-pyridyl)phosphanes (ALPYPHOS), 4,6-disubsituted 1,3-diazin-2-ylphosphanes or...

A new fluconazole-functionalized polyoxometalate-based metal-organic framework (POMOF) [Ag3(FKZ)2(H2O)2][H3SiW12O40] (AgFKZSiW12) was successfully constructed, and its polypyrrole (PPy) coated composite AgFKZSiW12@PPy also obtained via a facile 'in situ' oxidation polymerization process. The peroxidase-like activity evaluation indicates that the maximized synergistic effect from integration of PPy, SiW12 clusters, HFKZ drug molecules, Ag ions deeply enhanced overall performance. More...

The first polyoxometalate (POM)-containing nanocage based metal-organic framework (Zn-POMCF) was synthesized by a surfactant-assisted method. In contrast to the Zn-based (Zn-MOF), cooperative assembly of POM and Zn/trz macrocycle gave rise high stability good electrochemical ability Zn-POMCF in lithium-ion batteries (LIBs).

The synergy of chemodynamic therapy (CDT) and photothermal (PTT) can improve anticancer efficacy, while the limited diffusion distance short lifetime •OH still greatly restrict therapeutic efficacy PTT-CDT. Herein, MoS2@PDA-Fe@PEG/TPP (MPFPT) nanosheets (NSs) with mitochondria-targeting ability were reported for enhanced PTT-CDT synergistic oncotherapy. MPFPT NSs prepared by covalent modification poly(ethylene glycol) (PEG) triphenylphosphonium (TPP) on polydopamine (PDA)-Fe3+coated MoS2...

A novel “double-locked” probe, <bold>DCO-H2S-V</bold>, was prepared for detecting hydrogen sulfide in a highly viscous system and successfully used the changes of viscosity H₂S PC-12 cells.

Comprehensive Summary gem ‐Difluoroalkenes are considered ideal isosteres for metabolically susceptible carbonyl groups in modern drug discovery and medicinal chemistry. In addition, ‐difluoroalkenes used as versatile precursors the synthesis of difluoroalkylated compounds monofluoroalkenes. Therefore, a great deal effort has been devoted to developing efficient methods their preparation. The catalytic defluorinative functionalization trifluoromethyl alkenes represents useful strategy...

Bacterial infection, tissue hypoxia, and inflammatory oxidative stress are several key problems in wound healing of chronic infections. Herein, a multi-enzyme-like activity exhibiting multifunctional hydrogel made up mussel-inspired carbon dot reduced-Ag (CDs/AgNPs) Cu/Fe-nitrogen-doped (Cu,Fe-NC) was designed. Due to the loss glutathione (GSH) oxidase (OXD)-like nanozyme (decomposes O2 generate superoxide anion radical (O2˙-) hydroxyl production (˙OH)), exhibited excellent antibacterial...

The reactions of amino-alcohol derived Schiff-base ligands with Cu(<sc>ii</sc>) and Ni(<sc>ii</sc>) salts have afforded four novel polynuclear complexes, which exhibited interesting magnetic cytotoxic properties.

One‐pot system combining multi‐reactions is used to synthesize novel porphyrin‐glycopolymer conjugates. Sodium mercury amalgam catalyze the reactions: 1) reduction of RAFT polymerized poly(2‐(methacrylamido) glucopyranose) (PMAG), 2) converting protoporphyrin protoporphyrinogen, 3) thiol‐ene coupling reaction PMAG and protoporphyrinogen. The product oxidized in same pot generate final porphyrin‐PMAG resulting conjugates are characterized by NMR, GPC, UV‐Vis, fluorescence spectroscopy....

Screening results indicated that DCO-5 exhibited the highest sensitivity to viscosity and was insensitive polarity or pH, enables successful detection of changes in vivo .

To obtain highly sensitive and selective nanozymes, the ternary NiMo6/ZIF-67/C3N4 (n) nanocomposites were successfully fabricated in this work, namely, Anderson-type polyoxometalate (NH4)4[H6Ni(II)Mo6O24] (NiMo6) was encapsulated into customized cavities of ZIF-67 then fixed on graphitic carbon nitride (g-C3N4). By employing detection H2O2 ascorbic acid (AA) as a model reaction, exhibit excellent peroxidase-like activities, attributed to synergistic effect NiMo6, ZIF-67, g-C3N4, which (2)...

Abstract Developing highly active and sensitive peroxidase mimics for L ‐cysteine ( ‐Cys) colorimetric detection is very important biotechnology medical diagnosis. Herein, polyoxometalate‐doped porous Co 3 O 4 composite (NiMo 6 @Co ) was designed prepared the first time. Compared with pure commercial , NiMo (n) composites exhibit enhanced peroxidase‐mimicking activities stabilities due to strong synergistic effect between multi‐electron clusters. Moreover, of are heavily dependent on doping...

A pillared-layer metal–organic framework can be used to separate rhodamine B (RB) and methylene blue (MB) dye molecules in a short amount of time.

Identifying cancer at the cellular level during an early stage offers hope of greatly improved outcomes for patients. As potential biomarkers, nitroreductase (NTR) and human quinine oxidoreductase 1 (hNQO1) are overexpressed in many type cells. Simultaneous detection these two biomarkers would benefit diagnostic precision related cancers without yielding false positive results. Herein, based on a dye generated situ strategy, dual-enzyme-responsive probe, CNN, was rationally designed...

To explore a novel colorimetric biosensor with high sensibility and selectivity, new Wells-Dawson-type polyoxometalate (POM)-based metal-organic framework (MOF) an eightfold helix, [Cu9(FKZ)12(H2O)8][H3P2W18O62]2·4H2O (CuFKZP2W18) (HFKZ = 1-(2,4-difluorophenyl)-1,1-bis[(1H-1,2,4-triazol-1-yl)methyl] ethanol), was successfully synthesized; then, polypyrrole (PPy) introduced to fabricate CuFKZP2W18/PPy(n) nanocomposites (n 7%, 15%, 30%) via facile in situ oxidation polymerization process. All...

An efficient and novel visible-light-induced oxo-amination of terminal alkenes for the construction α-amino ketones with easily accessible green O2 as oxygen source has been developed. The transformation possesses advantages operational simplicity, a broad substrate scope, high atom economy, mild reaction conditions. mechanistic studies reveal that an energy transfer process probably occurs in initial stage, proceeds via β-scission alkoxyl radical species.