A5084145888- Genetic and Kidney Cyst Diseases
- Biomedical Research and Pathophysiology
- Osteoarthritis Treatment and Mechanisms
- Cell Adhesion Molecules Research
- Connexins and lens biology
- Microtubule and mitosis dynamics
- Epigenetics and DNA Methylation
- Protease and Inhibitor Mechanisms
- Cellular Mechanics and Interactions
- Galectins and Cancer Biology
- RNA Research and Splicing
- Renal and related cancers
- Hedgehog Signaling Pathway Studies
- Signaling Pathways in Disease
- Protist diversity and phylogeny
Ulsan National Institute of Science and Technology
2018-2024
ITGBL1 promotes chondrogenesis and protects joint cartilage from osteoarthritis by inhibiting integrin-extracellular matrix interaction.
Abstract The first Asian community conference on “Scientific research using Xenopus as an animal model system” was held in Osaka, Japan, from November 24 to 26, 2024. This event organized by the Korean Society for Development of KSMCB (Korean Molecular and Cellular Biology), Community Japan (XCIJ), KNU G‐LAMP Project, National BioResource Project—Clawed frogs/Newts (NBRP), Osaka University. covered various topics biological sciences . ultimate goal this promote collaboration encourage a new...
Chondrocytes secrete massive extracellular matrix (ECM) molecules that are produced, folded, and modified in the endoplasmic reticulum (ER). Thus, ER-associated degradation (ERAD) complex-which removes misfolded unfolded proteins to maintain proteostasis ER- plays an indispensable role building maintaining cartilage. Here, we examined necessity of ERAD complex chondrocytes for cartilage formation maintenance. We show gene expression is exponentially increased during chondrogenesis,...
The cilium is a microtubule-based organelle that plays pivotal role in embryonic development and maintenance of physiological functions the human body. In addition to their function as sensors transduce diverse extracellular signals, including growth factors, fluid flow, physical forces, cilia are intricately involved cell cycle regulation preservation DNA integrity, formation resorption dynamics tightly linked progression. Recently, several studies have defects specific ciliary proteins...
Motile cilia of multiciliated epithelial cells have important roles in animal development and cell homeostasis. Although several studies identified reported proteins localized this complex organelle the related immotile primary from various types, it is still challenging to isolate high quantities ciliary for proteomic analysis. In study, African clawed frog (Xenopus laevis) embryos, which many epidermis, were treated with a simple ionic buffer identify 1009 conserved across vertebrates;...
Abstract Background Cell migration is a basic cellular behavior involved in multiple phenomena the human body such as embryonic development, wound healing, immune reactions, and cancer metastasis. For proper cell migration, integrin ECM binding complex must be disassembled for retraction of trailing edges. Objective Integrin differentially regulated at leading edges or during migration. Previously, we showed that ITGBL1 was secreted protein inhibits activity. Therefore, examined function on...
The gap junction complex functions as a transport channel across the membrane. Among subunits, protein α1 (GJA1) is most commonly expressed subunit. A recent study showed that GJA1 necessary for maintenance of motile cilia; however, molecular mechanism and function in ciliogenesis remain unknown. Here, we examined during human retinal pigment epithelium-1 Xenopus laevis embryonic multiciliated-cells. localizes to ciliary axonemes or pericentriolar regions beneath primary cilium. depletion...
Abstract The gap junction complex functions as a transport channel across the membrane. Among subunits, protein α1 (GJA1) is most commonly expressed subunit. A recent study showed that GJA1 necessary for maintenance of motile cilia; however, molecular mechanism and function in ciliogenesis remain unknown. Here, we examined during human retinal pigment epithelium-1 Xenopus laevis embryonic multiciliated-cells. localizes to ciliary axonemes or pericentriolar regions beneath primary cilium....