A5090036612- Genomics and Phylogenetic Studies
- Enzyme Structure and Function
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Chromosomal and Genetic Variations
- Biochemical and Molecular Research
- RNA modifications and cancer
- Plant Virus Research Studies
- Genomic variations and chromosomal abnormalities
- Enzyme Catalysis and Immobilization
- Developmental Biology and Gene Regulation
- Congenital heart defects research
- Prenatal Screening and Diagnostics
- Ubiquitin and proteasome pathways
- Hearing, Cochlea, Tinnitus, Genetics
- RNA and protein synthesis mechanisms
- Cell Adhesion Molecules Research
- Microbial Metabolic Engineering and Bioproduction
- Cephalopods and Marine Biology
- Genetics and Neurodevelopmental Disorders
- Bacterial Genetics and Biotechnology
- Photoreceptor and optogenetics research
- Marine animal studies overview
- Osteoarthritis Treatment and Mechanisms
University of California, Berkeley
2014-2024
Instituto Tecnológico Superior de Irapuato
2017
Center for Research and Advanced Studies of the National Polytechnic Institute
2013-2017
Instituto Politécnico Nacional
2013-2017
Universidad Nacional Autónoma de México
2013
Center for Genomic Science
2007
Abstract Cephalopods are known for their large nervous systems, complex behaviors and morphological innovations. To investigate the genomic underpinnings of these features, we assembled chromosomes Boston market squid, Doryteuthis (Loligo) pealeii, California two-spot octopus, Octopus bimaculoides , compared them with those Hawaiian bobtail Euprymna scolopes . The genomes soft-bodied (coleoid) cephalopods highly rearranged relative to other extant molluscs, indicating an intense, early burst...
Abstract Frogs are an ecologically diverse and phylogenetically ancient group of anuran amphibians that include important vertebrate cell developmental model systems, notably the genus Xenopus . Here we report a high-quality reference genome sequence for western clawed frog, tropicalis , along with draft chromosome-scale sequences three distantly related emerging frog species, Eleutherodactylus coqui Engystomops pustulosus Hymenochirus boettgeri Frog chromosomes have remained remarkably...
Several lines of evidence suggest that reiterated sequences in the human genome are targets for nonallelic homologous recombination (NAHR), which facilitates genomic rearrangements. We have used a PCR-based approach to identify breakpoint regions rearranged structures genome. In particular, we identified intrachromosomal identical repeats located reverse orientation, may lead chromosomal inversions. A bioinformatic workflow pathway select appropriate analysis was developed. Three such...
During vertebrate neurulation, the embryonic ectoderm is patterned into lineage progenitors for neural plate, crest, placodes and epidermis. Here, we use Xenopus laevis embryos to analyze spatial temporal transcriptome of distinct ectodermal domains in course during establishment cell lineages. In order define small groups cells from a single germ layer retain information, dorsal ventral was subdivided along anterior-posterior medial-lateral axes by microdissections. Principal component...
ITGBL1 promotes chondrogenesis and protects joint cartilage from osteoarthritis by inhibiting integrin-extracellular matrix interaction.
Despite the prominent role of horizontal gene transfer (HGT) in shaping bacterial metabolism, little is known about impact HGT on evolution enzyme function. Specifically, what influence a recently acquired function an existing gene? For example, certain members genus Corynebacterium have horizontally whole l-tryptophan biosynthetic operon, whereas closely related actinobacteria, for Mycobacterium, trpF missing. In performed by dual-substrate (βα)8 phosphoribosyl isomerase (priA gene) also...
The connection between gene loss and the functional adaptation of retained proteins is still poorly understood. We apply phylogenomics metabolic modeling to detect bacterial species that are evolving by loss, with finding Actinomycetaceae genomes from human cavities undergoing sizable reductions, including L-histidine L-tryptophan biosynthesis. observe dual-substrate phosphoribosyl isomerase A or priA gene, at which these pathways converge, appears coevolve occurrence trp his genes....
Significance Deficits in hearing or balance are common and result from both developmental environmental causes. Model organisms have contributed many fundamental insights into embryonic development we added Xenopus tropicalis as a new genetically tractable organism the field of inner ear development. As forward genetic screen X. , identified specificity protein 8 initiator development, analyzed mutant phenotypes molecular interactions with genes that involved Given morphological similarities...
Abstract Frogs are an ecologically diverse and phylogenetically ancient group of living amphibians that include important vertebrate cell developmental model systems, notably the genus Xenopus . Here we report a high-quality reference genome sequence for western clawed frog, tropicalis , along with draft chromosome-scale sequences three distantly related emerging frog species, Eleutherodactylus coqui Engystomops pustulosus Hymenochirus boettgeri Frog chromosomes have remained remarkably...