A5032719909- Genetics, Aging, and Longevity in Model Organisms
- Amphibian and Reptile Biology
- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Insect-Plant Interactions and Control
- Insect Utilization and Effects
- Hemiptera Insect Studies
- Chromosomal and Genetic Variations
- Genomics and Phylogenetic Studies
- Insect and Pesticide Research
- Subterranean biodiversity and taxonomy
- Animal Behavior and Reproduction
- Physiological and biochemical adaptations
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genomics and Chromatin Dynamics
- Silk-based biomaterials and applications
- Plant and animal studies
- Crustacean biology and ecology
- Sirtuins and Resveratrol in Medicine
- Circadian rhythm and melatonin
- Parasite Biology and Host Interactions
- Marine Ecology and Invasive Species
- Plant Virus Research Studies
- Bacteriophages and microbial interactions
- Aquaculture disease management and microbiota
Harvard University
2017-2024
Wellesley College
2023-2024
University of Illinois Urbana-Champaign
2022
Harvard University Press
2022
National Institutes of Health
2012-2014
National Institute on Aging
2011-2012
Abstract Frogs are an ecologically diverse and phylogenetically ancient group of anuran amphibians that include important vertebrate cell developmental model systems, notably the genus Xenopus . Here we report a high-quality reference genome sequence for western clawed frog, tropicalis , along with draft chromosome-scale sequences three distantly related emerging frog species, Eleutherodactylus coqui Engystomops pustulosus Hymenochirus boettgeri Frog chromosomes have remained remarkably...
Many species adapted to aphotic subterranean habitats have lost all body pigmentation. Yet, melanization is an important component of wound healing in arthropods. We amputated appendages a variety cave-adapted and surface-dwelling A dark clot formed at the site injury most tested, including even albino species. The coloration clots was due melanin deposition. speed uncorrelated with difference metabolic rate between surface cave populations amphipod. chelicerate Limulus polyphemus, isopod...
Summary Reactive oxygen species (ROS) modulate aging and aging‐related diseases. Dietary composition is critical in modulating lifespan. However, how ROS dietary effects on lifespan remains poorly understood. Superoxide dismutase 1 (SOD1) a major cytosolic enzyme responsible for scavenging superoxides. Here we investigated the role of SOD1 modulation by diet Drosophila . We found that high sugar‐low protein (HS‐LP) or low‐calorie with low‐sugar content, representing restriction, increased...
Diet composition is a critical determinant of lifespan, and nutrient imbalance detrimental to health. However, how nutrients interact with genetic factors modulate lifespan remains elusive. We investigated diet influences mitochondrial ATP synthase subunit d (ATPsyn-d) in modulating Drosophila. ATPsyn-d knockdown extended females fed low carbohydrate-to-protein (C:P) diets but not the high C:P ratio diet. This extension was associated increased resistance oxidative stress; transcriptional...
Social justice is increasingly being seen as relevant to the science curriculum. We examine intersection of participatory science, social justice, and higher education in United States investigate how instructors can teach about enhance collaborations work toward enacting justice. Participatory approaches, like those that collect data over large geographic areas, be particularly useful for teaching students Conversely, local-scale approaches integrate into community efforts create powerful...
Sexual dimorphism is common in animals. The most complete model of sex determination comes from Drosophila melanogaster , where the relative dosage autosomes and X chromosomes leads indirectly to sex-specific transcripts doublesex ( dsx ). Female Dsx interacts with a mediator complex protein encoded by intersex ix ) activate female development. In males, transcription factor fruitless fru promotes male-specific behaviour. genetics have been examined small number other insects, yet several...
Botanicals possess numerous bioactivities, and some promote healthy aging. Dietary macronutrients are major determinants of life span. The interaction between botanicals that modulates span is not well understood. Here, we investigated the effect a cranberry-containing botanical on influence longevity-related cranberry in Drosophila. Flies were supplemented with three dietary conditions: standard, high sugar–low protein, low sugar–high protein diets. We found slightly extended males fed diet...
Direct development is a reproductive mode in amphibians that has evolved independently from the ancestral biphasic life history at least dozen anuran lineages. Most direct-developing frogs, including Puerto Rican coquí, Eleutherodactylus coqui, lack free-living aquatic larva and instead hatch terrestrial eggs as miniature adults. Their embryonic includes transient formation of many larval-specific features adult-specific typically form postembryonically—during metamorphosis—in...
Abstract Frogs are an ecologically diverse and phylogenetically ancient group of living amphibians that include important vertebrate cell developmental model systems, notably the genus Xenopus . Here we report a high-quality reference genome sequence for western clawed frog, tropicalis , along with draft chromosome-scale sequences three distantly related emerging frog species, Eleutherodactylus coqui Engystomops pustulosus Hymenochirus boettgeri Frog chromosomes have remained remarkably...
Sexual dimorphism is common in animals. The most complete model of sex determination comes from Drosophila melanogaster , where the relative dosage autosomes and X chromosomes leads indirectly to sex-specific transcripts doublesex . Female Dsx interacts with a mediator complex protein encoded by intersex activate female development. In males transcription factor fruitless promotes male-specific behavior. genetics have been examined small number other insects, yet several questions remain...
Abstract Sexual dimorphism is common in animals. The most complete model of sex determination comes from Drosophila melanogaster , where the relative dosage autosomes and X chromosomes leads indirectly to sex-specific transcripts doublesex . Female Dsx interacts with a mediator complex protein encoded by intersex activate female development. In males transcription factor fruitless promotes male-specific behavior. genetics have been examined small number other insects, yet several questions...
Being able to communicate scientifically is an important skill for students graduating with a science degree. Skills used in future graduate school and careers majors include oral written communication, as well literacy being create figures display information. There consensus that these skills should be taught throughout undergraduate curriculum; however, many instructors have cited insufficient time cover develop materials effectively incorporate skills, especially into lower-level...