A5087921536- Genetics and Neurodevelopmental Disorders
- Congenital heart defects research
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Autism Spectrum Disorder Research
- Genomics and Chromatin Dynamics
- Cell Image Analysis Techniques
- Chromatin Remodeling and Cancer
- Neurogenesis and neuroplasticity mechanisms
- Single-cell and spatial transcriptomics
- RNA modifications and cancer
- Pluripotent Stem Cells Research
- Bioinformatics and Genomic Networks
University of California, San Francisco
2018-2024
University of California, Berkeley
2015-2018
Summary Recent studies have identified over one hundred high-confidence (hc) autism spectrum disorder (ASD) genes. Systems biological and functional analyses on smaller subsets of these genes consistently implicated excitatory neurogenesis. However, the extent to which broader set hcASD are involved in this process has not been explored systematically nor pathways underlying convergence identified. Here, we leveraged CROP-Seq repress 87 a human vitro model cortical We 17 whose repression...
ABSTRACT Autism spectrum disorder (ASD) commonly co-occurs with congenital heart disease (CHD), but the molecular mechanisms underlying this comorbidity remain unknown. Given that children CHD come to clinical attention by newborn period, understanding which variants carry ASD risk could provide an opportunity identify and treat individuals at high for developing far before typical age of diagnosis. Therefore, it is critical delineate subset genes most likely increase ASD. However, date...
Metazoan development depends on tightly regulated gene expression programs that instruct progenitor cells to adopt specialized fates. Recent work found posttranslational modifications, such as monoubiquitylation, can determine cell fate also independently of effects transcription, yet how monoubiquitylation is implemented during poorly understood. Here, we have identified a regulatory circuit controls monoubiquitylation-dependent neural crest specification by the E3 ligase CUL3 and its...