A5101945694- Osteoarthritis Treatment and Mechanisms
- Protease and Inhibitor Mechanisms
- Galectins and Cancer Biology
- Phytochemistry and Biological Activities
- Phytochemicals and Antioxidant Activities
- Genetic and Kidney Cyst Diseases
- RNA Research and Splicing
- Pluripotent Stem Cells Research
- CAR-T cell therapy research
- CRISPR and Genetic Engineering
- Renal and related cancers
- Vehicle emissions and performance
- Microtubule and mitosis dynamics
- Genetics, Aging, and Longevity in Model Organisms
- Cell Adhesion Molecules Research
- Protist diversity and phylogeny
- Health and Wellbeing Research
- Air Quality Monitoring and Forecasting
- Education, Safety, and Science Studies
- Natural product bioactivities and synthesis
- Healthcare Education and Workforce Issues
- Birth, Development, and Health
- Air Quality and Health Impacts
- Diverse Approaches in Healthcare and Education Studies
Ulsan National Institute of Science and Technology
2018-2025
Daegu University
2018
ITGBL1 promotes chondrogenesis and protects joint cartilage from osteoarthritis by inhibiting integrin-extracellular matrix interaction.
An ideal cancer therapeutic strategy involves the selective killing of cells without affecting surrounding normal cells. However, researchers have failed to develop such methods for achieving cell death because shared features between cancerous and In this study, we developed a called cancer-specific insertions-deletions (InDels) attacker (CINDELA) selectively induce using CRISPR-Cas system. CINDELA utilizes previously unexplored idea introducing CRISPR-mediated DNA double-strand breaks...
TNF receptor-associated protein1 (TRAP1) is a mitochondrial molecular chaperon with high homology cytosolic HSP90. It has been shown that TRAP1 functions as an inhibitor for apoptosis by preventing cytochrome-c release from mitochondria. In addition, seems to play critical roles in metabolic processes energy production, such glycolysis and β-oxidation. also reported direct target of PTEN-induced kinase 1 (PINK1) may be cause Parkinson's disease (PD) humans. Although the biochemical are under...
Chondrocytes secrete massive extracellular matrix (ECM) molecules that are produced, folded, and modified in the endoplasmic reticulum (ER). Thus, ER-associated degradation (ERAD) complex-which removes misfolded unfolded proteins to maintain proteostasis ER- plays an indispensable role building maintaining cartilage. Here, we examined necessity of ERAD complex chondrocytes for cartilage formation maintenance. We show gene expression is exponentially increased during chondrogenesis,...
Motile cilia of multiciliated epithelial cells have important roles in animal development and cell homeostasis. Although several studies identified reported proteins localized this complex organelle the related immotile primary from various types, it is still challenging to isolate high quantities ciliary for proteomic analysis. In study, African clawed frog (Xenopus laevis) embryos, which many epidermis, were treated with a simple ionic buffer identify 1009 conserved across vertebrates;...
Abstract Exposure to particulate matter (PM) in ambient air is known increase the risk of cardiovascular disorders and mortality. The cytotoxicity PM mainly due abnormal reactive oxygen species (ROS), which damage cellular components such as DNA, RNA, proteins. correlation between exposure human disorders, including mortality, based on long-term exposure. In this study we have investigated acute responses mucus-secreting goblet cells upon derived from a heavy diesel engine. To end, employed...
This study explores the negative impact of caregivers' social capital on use welfare services through a case child abuse death incident in Yangcheon-gu. By applying theory, analyzes how intangible restricts rights and choices vulnerable users, such as children, operation services. The research methods involved frequency analysis literature using Textom, revealing structural issues where children’s choice were limited due to caregivers’ during handling cases by key actors police, daycare...
The aim of this study was to investigate the antioxidant and intracellular anti-inflammatory efficacy hardy kiwifruit extracted with hot water (HKW), 70% ethanol (HKE), acetone (HKA) in RAW 264.7 macrophages. In order evaluate effect extracts, macrophages were stimulated lipopolysaccharide (LPS) induce production inflammation-related factors, which measured by Western blotting real-time PCR methods. i-NOS, COX-2, NF-κB protein, mRNA expression showed a concentration-dependent effect....
Purpose: This study aims to understand the perception of pediatric hospice palliative care and meaning life undergraduate nursing students. Methods: To achieve study''s purpose, 136 students were surveyed, results analyzed with SPSS Statistics using an independent t-test. Results: The students'' was positive. according perceptions showed a significant difference in awareness necessity wards university hospitals. Finally, education on insufficient knowledge is needed. Conclusion: Based these...