A5085856143- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Insect symbiosis and bacterial influences
- Genomics and Phylogenetic Studies
- Protist diversity and phylogeny
- Mosquito-borne diseases and control
- Malaria Research and Control
- Vector-borne infectious diseases
- Heavy metals in environment
- Microbial Community Ecology and Physiology
- Photosynthetic Processes and Mechanisms
- Liver Disease Diagnosis and Treatment
- Parasites and Host Interactions
- vaccines and immunoinformatics approaches
- Virology and Viral Diseases
- Parasitic Infections and Diagnostics
- Helminth infection and control
- Coal and Its By-products
- Invertebrate Immune Response Mechanisms
- Liver Disease and Transplantation
- Bacterial Infections and Vaccines
- Heavy Metals in Plants
- Exercise and Physiological Responses
- Lipid Membrane Structure and Behavior
- Biochemical and Molecular Research
University of Liverpool
2016-2025
Institute of Genetics and Cancer
2025
University of Edinburgh
2020-2025
Edinburgh College
2020
University of Nottingham
2012-2020
University of Cape Coast
2020
Kwame Nkrumah University of Science and Technology
2020
Kwame Nkrumah University
2020
West Midlands Deanery
2016
Loughborough University
2014
Four distinct Plasmodium species are known to regularly infect humans: falciparum, P. vivax, malariae and ovale. The genome sequence of the cause most severe type human malaria, was completed in 2002 at same time as mosquito vector, Anopheles gambiae. In this week's Nature, which focuses on malaria parasite, two further sequences described. First that contributes significant numbers incidence humans, though contrast resulting disease is usually not fatal. rather neglected presented together...
Subtelomeric regions are often under-represented in genome sequences of eukaryotes. One the best known examples use telomere proximity for adaptive purposes bloodstream expression sites (BESs) African trypanosome Trypanosoma brucei. To enhance our understanding BES structure and function host adaptation immune evasion, repertoire from Lister 427 strain T. brucei were independently tagged sequenced. BESs polymorphic size but reveal a surprisingly conserved architecture context extensive...
Rodent malaria parasites (RMP) are used extensively as models of human malaria. Draft RMP genomes have been published for Plasmodium yoelii, P. berghei ANKA (PbA) and chabaudi AS (PcAS). Although availability these made a significant impact on recent research, were highly fragmented annotated with little manual curation. The nature the has hampered genome wide analysis gene regulation function.
Candida dubliniensis is the closest known relative of albicans , most pathogenic yeast species in humans. However, despite both sharing many phenotypic characteristics, including ability to form true hyphae, C. a significantly less virulent and versatile pathogen. Therefore, identify -specific genes that may be responsible for an increased capacity cause disease, we have sequenced genome compared it with sequence. Although two sequences are highly similar synteny conserved throughout, 168...
Antigenic variation enables pathogens to avoid the host immune response by continual switching of surface proteins. The protozoan blood parasite Trypanosoma brucei causes human African trypanosomiasis ("sleeping sickness") across sub-Saharan Africa and is a model system for antigenic variation, surviving periodically replacing monolayer variant glycoproteins (VSG) that covers its cell surface. We compared genome with two closely related parasites congolense vivax, reveal how antigen...
Background Trypanosoma brucei gambiense is the causative agent of chronic Human African Trypanosomiasis or sleeping sickness, a disease endemic across often poor and rural areas Western Central Africa. We have previously published genome sequence T. b. isolate, now employed comparative genomics approach to understand scale genomic variation between reference genome. sought identify features that were uniquely associated with its ability infect humans. Methods Findings An improved...
Two key biological features distinguish Trypanosoma evansi from the T. brucei group: independence tsetse fly as obligatory vector, and need for functional mitochondrial DNA (kinetoplast or kDNA). In an effort to better understand molecular causes consequences of these differences, we sequenced genome akinetoplastic strain China compared it b. reference strain. The annotated shows extensive similarity reference, with 94.9% predicted coding sequences (CDS) having ortholog in evansi, 94.6%...
The cell surface of Trypanosoma brucei, like many protistan blood parasites, is crucial for mediating host-parasite interactions and instrumental to the initiation, maintenance severity infection. Previous comparisons with related trypanosomatid parasites T. cruzi Leishmania major suggest that cell-surface proteome brucei largely taxon-specific. Here we compare genes predicted encode proteins those from two African trypanosomes, congolense vivax. We created a phylome (CSP) by estimating...
Photosynthetic euglenids are major contributors to fresh water ecosystems. Euglena gracilis in particular has noted metabolic flexibility, reflected by an ability thrive a range of harsh environments. E. been popular model organism and considerable biotechnological interest, but the absence gene catalogue hampered both basic research translational efforts. We report detailed transcriptome partial genome for Z1. The nuclear is estimated be around 500 Mb size, encodes over 36,000 proteins...
Babesia spp. are tick-borne, intraerythrocytic hemoparasites that use antigenic variation to resist host immunity, through sequential modification of the parasite-derived variant erythrocyte surface antigen (VESA) expressed on infected red blood cell surface. We identified genomic processes driving diversity in genes encoding VESA (ves1) comparative analysis within and between three species, (B. bigemina, B. divergens bovis). Ves1 structure diverges rapidly after speciation, notably...
Environmental Science Unit, Department of Geography, Queen Mary and Westfield College, University London, Mile End Road, London E1 4NS, UKCadmium has no known essential biological function is potentially toxic to both plants animals. This paper reviews the behavior Cd in human food chain. The transfer along soil-plant-human pathway considered for soils that have been treated with sewage sludge. Only soil-plant pathway because food crops dominate exposure profile. importance this mode...
Rhs genes are prominent features of bacterial genomes that have previously been implicated in genomic rearrangements E. coli. By comparing rhs repertoires across the Enterobacteriaceae, this study provides a robust explanation diversification and evolution, mechanistic model how diversity is gained lost. ubiquitous comprise six structurally distinct lineages within Enterobacteriaceae. There considerable intergenomic variation repertoire; for instance, Salmonella enterica, restricted to...
Abstract Many high-quality genomes are available for dixenous (two hosts) trypanosomatid species of the genera Trypanosoma , Leishmania and Phytomonas but only fragmentary information is monoxenous (single-host) trypanosomatids. In trypanosomatids, monoxeny ancestral to dixeny, thus it anticipated that genome sequences key parasites will be instrumental both understanding origin parasitism evolution dixeny. Here, we present a Leptomonas pyrrhocoris which closely related genus . The L. (30.4...
Many variant proteins encoded by Plasmodium-specific multigene families are exported into red blood cells (RBC). P. falciparum-specific the var, stevor and rifin onto surface of infected (iRBC) mediate interactions between iRBC host resulting in tissue sequestration rosetting. However, precise function most other Plasmodium encoding is unknown. To understand role RBC-exported rodent malaria parasites (RMP) we analysed expression cellular location fluorescent-tagging members pir, fam-a fam-b...
The extent to which viruses and their hosts codiverge remains an open question, given that numerous cases of both "cospeciation" horizontal switching have recently been documented. DNA form persistent infections are thought be the most likely candidates for phylogenetic congruence. Phylogenetic reconciliation analysis was used compare established phylogenies four RNA hosts. employs a cophylogeny mapping technique, implemented in TreeMap v2.0, find parsimonious combinations evolutionary...
Amastin is a transmembrane glycoprotein found on the cell surfaces of trypanosomatid parasites. Encoded by large, diverse gene family, amastin was initially described from intracellular, amastigote stage Trypanosoma cruzi and Leishmania donovani. Genome sequences have subsequently shown that repertoire much larger in relative to Trypanosoma. However, it not known when this expansion occurred, whether associated with origins vertebrate parasitism itself, or prior this. To examine timing...
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