A5100696235- Neuroinflammation and Neurodegeneration Mechanisms
- Neuropeptides and Animal Physiology
- Dementia and Cognitive Impairment Research
- Sleep and related disorders
- EEG and Brain-Computer Interfaces
- Peptidase Inhibition and Analysis
- Acute Ischemic Stroke Management
- Brain Tumor Detection and Classification
- Lung Cancer Research Studies
- Sleep and Wakefulness Research
- Alzheimer's disease research and treatments
- Pomegranate: compositions and health benefits
- Olfactory and Sensory Function Studies
- Parkinson's Disease Mechanisms and Treatments
- Inflammation biomarkers and pathways
- Trace Elements in Health
- Antioxidant Activity and Oxidative Stress
- Circadian rhythm and melatonin
- Phytochemicals and Antioxidant Activities
- Gut microbiota and health
- Nuclear Receptors and Signaling
- Clostridium difficile and Clostridium perfringens research
- Retinoids in leukemia and cellular processes
- Receptor Mechanisms and Signaling
- Intensive Care Unit Cognitive Disorders
WinnMed
2019-2023
Qingdao University
2021-2022
Affiliated Hospital of Qingdao University
2021-2022
Nanjing University of Chinese Medicine
2022
Zhejiang University
2021
First Affiliated Hospital of Xi'an Jiaotong University
2021
Hefei University of Technology
2020
First Hospital of Shijiazhuang
2019
Zhangjiakou Academy of Agricultural Sciences
1997
Objectives: Neurite outgrowth of neurons is essential for forming functional neural circuits. It believed that neuronal neurite an important mechanism brain plasticity. Rosuvastatin (RSV) a relatively new statin and may have neuroprotective properties. However, whether RSV exerts effect on extension its potential in cortical remains poorly documented.Methods: Immunofluorescence method was used to examine the primary neuron by measuring length confirmed promotion effect. Then, mechanisms...
Objective: Growing evidence suggests that sleep disturbance is a risk factor for Alzheimer's disease (AD). Amyloid-β (Aβ) deposition in the brain main pathophysiology of AD. Considering peripheral Aβ level associated with deposition, present study investigated relationship between and plasma levels. Methods: This population-based cross-sectional study. A total 1,459 participants from village suburbs Xi'an, China, were enrolled January 3, 2017 to March 26, 2017. Sleep quality was assessed...
CC-chemokine ligand 2 (CCL2), the key immunomodulatory chemokine for microglial activation, has been implicated in pathogenesis of Alzheimer's disease (AD). Whether association CCL2 single nucleotide polymorphisms (SNPs) and risk AD is still controversial.We aimed to investigate whether rs4586 SNP associated with pathological changes cognitive decline AD.A total 486 participants longitudinal cerebrospinal fluid (CSF) amyloid-β (Aβ) phospho-tau (P-tau) biomarkers, 18F-Florbetapir...
Cholecystokinin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on CCK [89]) are activated endogenous peptides cholecystokinin-8 (CCK-8), CCK-33, CCK-58 and gastrin (gastrin-17). There only two distinct subtypes of receptors, CCK1 CCK2 [63, 123], with some alternatively spliced forms most often identified in neoplastic cells. The receptor distinguished their peptide selectivity, requiring carboxyl-terminal heptapeptide-amide that includes a sulfated tyrosine for high affinity...
Objective: Pomegranate extract gallic acid inhibits the proliferation of prostate cancer PC-3 cells by promoting IGFBP7 expression.Methods: were divided into six groups: control group (NC), blank (BL), overexpression (IGFBP7), (5.0 μmol/L, 10.0 20.0 μmol/L).Cell was detected MTT assay; apoptosis each analyzed flow cytometry; expression levels IGFBP7, AKT and mTOR assessed Western blot.Results: The proliferative plural in pomegranate significantly lower than those NC BL groups (P < 0.05).The...
Cholecystokinin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on CCK [90]) are activated endogenous peptides cholecystokinin-8 (CCK-8), CCK-33, CCK-58 and gastrin (gastrin-17). There only two distinct subtypes of receptors, CCK1 CCK2 [64, 124], with some alternatively spliced forms most often identified in neoplastic cells. The receptor distinguished their peptide selectivity, requiring carboxyl-terminal heptapeptide-amide that includes a sulfated tyrosine for high affinity...
Alzheimer disease (AD) is a chronic neurodegenerative threating the health of human being. The clinical symptoms mainly consist severe cognitive impairment, comprehensive dementia, memory loss and other mental behavioral problems. According to data that collected in 2018, AD has become sixth fatal worldwide. Nevertheless, pathogenesis not been clarified, except for two main pathological features: from extracellular, amyloid plagues appear dendrites which caused by formation toxic amyloid-β...