A5044489867- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Cellular transport and secretion
- Ion Transport and Channel Regulation
- Blood Pressure and Hypertension Studies
- Receptor Mechanisms and Signaling
- Healthcare cost, quality, practices
- Reproductive Health and Contraception
- Health Systems, Economic Evaluations, Quality of Life
- Reproductive Health and Technologies
- Ubiquitin and proteasome pathways
- Retinal Development and Disorders
- Health and Medical Research Impacts
- Lipid metabolism and biosynthesis
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Endoplasmic Reticulum Stress and Disease
- Maternal and Perinatal Health Interventions
AmerisourceBergen (United States)
2023
University College London
2015-2019
Many membrane receptors activate phospholipase C (PLC) during signalling, triggering changes in the levels of several plasma (PM) lipids including PtdIns, PtdOH and PtdIns(4,5)P2. It is widely believed that exchange between PM endoplasmic reticulum (ER) required to restore lipid homeostasis PLC yet mechanism remains unresolved. RDGB a multi-domain protein with PITP domain (RDGB-PITPd). We find vitro, RDGB-PITPd binds transfers both PtdIns. In Drosophila photoreceptors experience high rates...
CDP diacylglycerol synthase (CDS) catalyses the conversion of phosphatidic acid (PA) to CDP-diacylglycerol, an essential intermediate in synthesis phosphatidylglycerol, cardiolipin and phosphatidylinositol (PI). CDS activity has been identified mitochondria endoplasmic reticulum mammalian cells apparently encoded by two highly-related genes, CDS1 CDS2. Cardiolipin is exclusively synthesised recent studies cardiomyocytes suggest that peroxisome proliferator-activated receptor γ coactivator 1...
We describe the substantial shortfall in adherence to guideline-recommended albumin-to-creatinine ratio (uACR) testing for people United States with type 2 diabetes. Poor compliance current guidelines leads delays diagnosis-and treatment- of chronic kidney disease, which adversely affects clinical outcomes and contributes incremental economic burden.
Chronic stimulation (24 h) with vasopressin leads to hypertrophy in H9c2 cardiomyoblasts and this is accompanied by continuous activation of phospholipase C. Consequently, a depletion phosphatidylinositol levels. The substrate for C (4, 5) bisphosphate (PIP2) resynthesis its subsequent phosphorylation maintains the supply PIP2. PI requires conversion phosphatidic acid CDP-diacylglycerol catalysed synthase (CDS) enzymes. To examine whether regulated stimulation, we focussed on CDS Three...