A5017310008- HIV Research and Treatment
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- HIV/AIDS Research and Interventions
- Virus-based gene therapy research
- HIV-related health complications and treatments
- vaccines and immunoinformatics approaches
- Immunotherapy and Immune Responses
- CRISPR and Genetic Engineering
- Cytomegalovirus and herpesvirus research
- Immunodeficiency and Autoimmune Disorders
- HIV/AIDS drug development and treatment
- RNA Interference and Gene Delivery
- Virology and Viral Diseases
- Mental Health Research Topics
- Neurological and metabolic disorders
- RNA regulation and disease
- T-cell and Retrovirus Studies
- Herpesvirus Infections and Treatments
- Chemical and Physical Studies
- Growth Hormone and Insulin-like Growth Factors
- Diabetes and associated disorders
- Primate Behavior and Ecology
- Erythrocyte Function and Pathophysiology
- Renal Transplantation Outcomes and Treatments
Kindai University
2017-2024
Niigata University of Health and Welfare
2022-2024
Kumamoto University
2016-2020
UNSW Sydney
2017-2019
The University of Tokyo
2006-2012
National Institute of Infectious Diseases
2007-2010
Tokyo University of Science
2007-2009
Gag-specific cytotoxic T lymphocytes (CTLs) exert strong suppressive pressure on human immunodeficiency virus (HIV) and simian (SIV) replication. However, it has remained unclear whether they can actually contain primary viral Recent trials of prophylactic vaccines inducing virus-specific T-cell responses have indicated their potential to confer resistance against SIV replication in rhesus macaques, while the immunological determinant for this vaccine-based control not been elucidated thus...
ABSTRACT Induction of virus-specific CD8 + cytotoxic T-lymphocyte (CTL) responses is a promising strategy for AIDS vaccine development. However, it has remained unclear if or how long-term viral containment and disease control are attainable by CTL-based nonsterile protection. Here, we present three rhesus macaques that successfully maintained Env-independent vaccine-based simian immunodeficiency virus (SIV) mac239 replication without progression more than 3 years. SIV-specific neutralizing...
Cytotoxic T-lymphocyte (CTL) responses are crucial for the control of immunodeficiency virus replication. Possible involvement a dominant single epitope-specific CTL in viral replication has recently been indicated preclinical AIDS vaccine trials, but it remained unclear if multiple CTLs can be involved vaccine-based control. Here, by following up five rhesus macaques that showed primary simian virus, SIVmac239, we present evidence indicating this Three maintained more than 2 years without...
Rapid depletion of memory CD4(+) T cells and delayed induction neutralizing antibody (NAb) responses are characteristics human immunodeficiency virus (HIV) simian (SIV) infections. Although it was speculated that postinfection NAb could have only a limited suppressive effect on primary HIV replication, recent study has shown single passive immunization rhesus macaques 1 week after SIV challenge can result in reduction viral loads at the set point, indicating possible contribution to control....
ABSTRACT Nonhuman primate AIDS models are essential for the analysis of pathogenesis and evaluation vaccine efficacy. Multiple studies on human immunodeficiency virus simian (SIV) infection have indicated association major histocompatibility complex class I (MHC-I) genotypes with rapid or slow progression. The accumulation macaque groups that share not only a single MHC-I allele but also an haplotype consisting multiple polymorphic loci would greatly contribute to progress research. Here, we...
Despite many efforts to develop AIDS vaccines eliciting virus-specific T-cell responses, whether induction of these memory T cells by vaccination before human immunodeficiency virus (HIV) exposure can actually contribute effective responses postinfection remains unclear. In particular, HIV-specific CD4(+) may increase the target cell pool for HIV infection because preferentially infects cells. However, helper are thought be important functional CD8(+) cytotoxic-T-lymphocyte (CTL) in...
ABSTRACT Cytotoxic T lymphocyte (CTL) responses play a central role in viral suppression human immunodeficiency virus (HIV) infections. Prophylactic vaccination resulting effective CTL after exposure would contribute to HIV control. It is important know how memory induction by affects postexposure responses. We previously showed vaccine-based control of simian (SIV) challenge group Burmese rhesus macaques sharing major histocompatibility complex class I haplotype. Gag 206-216 and 241-249...
Abstract Objectives Galectin‐9 (Gal‐9) is an immune checkpoint ligand for T‐cell immunoglobulin and mucin domain 3. Although the roles of Gal‐9 in regulating responses have been well investigated, their biological yet to be fully documented. This study aimed analyse expression bone marrow (BM) cells C57BL/6J (B6) mice. Furthermore, co‐expression with mammalian target rapamycin (mTOR) AMP‐activated protein kinase (AMPK) was investigated. Methods The BM adult mice were collected analysed...
Recent recombinant viral vector-based AIDS vaccine trials inducing cellular immune responses have shown control of CXCR4-tropic simian-human immunodeficiency virus (SHIV) replication but difficulty in containment pathogenic CCR5-tropic simian (SIV) rhesus macaques. In contrast, controlled infection live attenuated SIV/SHIV can confer the ability to contain SIV superchallenge The specific responsible for this may be induced by not consistently vector vaccination, although those been...
Objectives: Hematological abnormalities that include changes in bone marrow, such as anemia and pancytopenia, are common among HIV-infected patients, particularly the advanced stage of disease. Such may be caused by a reduced marrow function for hematopoiesis. The aim this study was to determine whether transcriptional gene silencing can help preserve hosts’ hematopoietic potential addition peripheral CD4+ T cells against CCR5-tropic HIV infection. Design: NOD/SCID/JAK3null (NOJ) mice were...
Objective: In our prior study on a prophylactic T-cell-based vaccine, some vaccinated macaques controlled simian immunodeficiency virus (SIV) challenge. These animals allowed viremia in the acute phase but showed persistent viral control after setpoint. Here, we examined breadth of postchallenge virus-specific cellular immune responses these SIV controllers. Design: We previously reported that group Burmese rhesus possessing MHC haplotype 90-120-Ia, immunization with Gag-expressing vaccine...
HIV-1 causes the loss of CD4+ T cells via depletion or impairment their production. The latter involves infection thymocytes, but involvement hematopoietic CD34+ remains unclear even though HIV-positive patients frequently manifest myelosuppression. In order to have a closer look at impact on T-lineage differentiation, this study utilized OP9-DL1 coculture system, which supports in vitro differentiation human stem/progenitor cells. newly developed OP9-DL1/HIV-1 model, cord-derived were...
The X4-tropic simian/human immunodeficiency virus (SHIV) 89.6P (or 89.6PD) causes rapid CD4(+) T-cell depletion leading to an acute crash of the host immune system, whereas pathogenic R5-tropic simian (SIV) infection, like HIV-1 infection in humans, results chronic disease progression macaques. Recent pre-clinical vaccine trials inducing cytotoxic T lymphocyte (CTL) responses have succeeded controlling replication former but shown difficulty control latter. Analysis involved consistent SHIV...
Cytotoxic-T-lymphocyte (CTL) responses are important to control the replication of human immunodeficiency virus (HIV) and simian (SIV). Accumulating evidence suggests that ability a few immunodominant T-cell populations detect kill HIV/SIV-infected cells is in individuals with protective major histocompatibility complex class I (MHC-I) allele. On other hand, immunization live(-attenuated) viruses may be effective against superinfection virulent viral strains regardless host's MHC-I...
Anti-Yo (also called PCA-1, APCA-1, or Type I) antibody is present in the sera and CSF patients with gynecologic breast cancers paraneoplastic cerebellar degeneration (PCD). Immunohistochemistry revealed anti-Purkinje cell a patient PCD associated ovarian cancer. [1] Cunningham et al. [2] reported that this recognized 62-kd 34-kd bands on an immunoblot of human Purkinje extracts. Tsukamoto [3] four uterine cancer whose labeled cytoplasm cells other neurons CNS 52-kd band rat homogenates....