A5066629041- Iron and Steelmaking Processes
- Polymer Surface Interaction Studies
- Advanced Polymer Synthesis and Characterization
- Thermochemical Biomass Conversion Processes
- Mineral Processing and Grinding
- Coal and Coke Industries Research
- RNA Interference and Gene Delivery
- Coal Properties and Utilization
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Metal Extraction and Bioleaching
- Advanced materials and composites
- Membrane Separation Technologies
- Coal Combustion and Slurry Processing
- Advanced Drug Delivery Systems
- biodegradable polymer synthesis and properties
- Thermal and Kinetic Analysis
- Block Copolymer Self-Assembly
- Trypanosoma species research and implications
- Microplastics and Plastic Pollution
- Solar-Powered Water Purification Methods
- Membrane-based Ion Separation Techniques
- Recycling and Waste Management Techniques
- Surfactants and Colloidal Systems
- Lysosomal Storage Disorders Research
University of Newcastle Australia
2016-2024
The University of Melbourne
2011-2014
University of Sheffield
2007-2010
University of Oxford
2009
Biocompatibles (United Kingdom)
2008
A novel gene delivery vector based on the ability of a synthetic amphiphilic block copolymer to mimic biological phospholipids by forming membrane-enclosed structures, specifically nanometer-sized vesicles, is presented. pH-sensitive diblock forms vesicles (polymersomes) at neutral pH, and dissolves completely as unimers endocytic pH (see figure). GFP-encoding plasmid DNA are successfully encapsulated inside polymer delivered intracellularly. Supporting information for this article available...
Provided the right hydrophilic/hydrophobic balance can be achieved, amphiphilic block copolymers are able to assemble in water into membranes. These membranes enclose forming spheres with an aqueous core. Such structures, known as polymer vesicles or polymersomes (from Greek "-some" = "body of"), have sizes that vary from tens thousands of nanometers. The wholly synthetic nature affords control over parameters such molar mass and composition which ultimately determine structure properties...
The synthesis of a series thermo-responsive ABA triblock copolymers in which the outer A blocks comprise poly(2-hydroxypropyl methacrylate) and central B block is poly(2-(methacryloyloxy)ethyl phosphorylcholine) achieved using atom transfer radical polymerization. These novel form thermo-reversible physical gels with critical gelation temperatures mechanical properties that are highly dependent on copolymer composition concentration. TEM studies dried dilute solutions indicate presence...
Abstract The formation of a novel drug‐delivery carrier for the controlled release plasmid DNA that comprises layer‐by‐layer polymer capsules subcompartmentalized with pH‐sensitive nanometer‐sized polymersomes is reported. amphiphilic diblock copolymer poly(oligoethylene glycol methacrylate)‐ block ‐poly(2‐(diisopropylamino)ethyl methacrylate) forms at physiological pH, but transitions to unimeric chains upon acidification cellular endocytic pH. These can thus an encapsulated payload in...
Layer-by-layer (LbL)-engineered particles have recently emerged as a promising class of materials for applications in biomedicine, with studies progressing from vitro to vivo. The versatility LbL assembly coupled particle templating has led engineered specific properties (e.g., stimuli-responsive, high cargo encapsulation efficiency, targeting), thus offering new opportunities targeted and triggered therapeutic release. This Perspective highlights an important development by Poon et al. on...
Abstract We report the self‐assembly of a series amphiphilic diblock copolymers comprising biocompatible, hydrophilic block, poly(2‐methacryloyloxyethyl phosphorylcholine) (PMPC) and pH‐sensitive poly(2‐(diisopropylamino)ethyl methacrylate) (PDPA), into dispersion colloidally stable, nanometer‐sized polymersomes at physiological pH salt concentration. The pH‐sensitivity PDPA block affords electrostatic interaction these with nucleic acids endocytic pH, as result protonation its tertiary...
In recent years, interest in mimicking the complex hierarchical architectures and functionalities of biological systems associated spatially confined reactions has led to design synthesis a range multicompartment particles. Multicompartmentalization allows incorporation structures single particle, thus allowing optimization physicochemical properties assembly (e.g., permeability, stability, stimuli-response) various multiple, separated reactions. this Perspective, we describe particle-based...
The N-alkylated deoxynojirimycin compound, N-(6'-(4''-azido-2''-nitrophenylamino)hexyl)-1-deoxynojirimycin (6) was synthesised as a potential photoaffinity probe for endoplasmic reticulum (ER) alpha-glucosidases I and II. Surprisingly this compound highly potent inhibitor of alpha-glucosidase (IC(50), 17 nM) in an vitro assay proved equally effective at inhibiting cellular ER glucosidases, determined by free oligosaccharide (FOS) analysis. A modest library compounds to obtain...
The steel industry is one of the largest industrial carbon dioxide emitters, accounting for up to 7% global emissions. Increasingly stringent emission regulations are prompting and coal industries explore implement abatement strategies through both incremental development current technologies incorporation new, innovative ones. This paper reviews status future sustainable cokemaking, aiming identify suitable carbonaceous materials partial displacement in metallurgical coking blends desirable...
The present study reports the synthesis of spray-coated cross-linked polyelectrolyte multilayer membranes. Membrane cross-linking was performed using alkyne-azide "click" chemistry, where alkyne and azide functional groups were used to modify poly(acrylic acid) (PAA) poly(allylamine) hydrochloride (PAH) polyelectrolytes. results demonstrate that deposition at lower ionic strength produced smoother denser membrane structures. Pore size analysis neutral poly(ethylene glycol) revealed a...
A novel approach was developed to examine coke abrasion resistance in-situ at temperatures of up 950 °C and in a controlled gas atmosphere using rotational tribological testing. The originality this lay the ability apply testing porous surface elevated under inert or CO2 reactive atmosphere. Coke wear characteristics were quantified via (i) application advanced microscopy image analysis techniques, (ii) coefficient friction (COF) during Two pilot oven cokes examined study, which generated...