This paper describes the double phase transition behavior of a thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) brush at surface hydrophobic core. Reversible addition-fragmentation transfer (RAFT) polymerization N-isopropylacrylamide (NIPAM) was conducted by using hyperbranched polyester (Boltorn H40) based macroRAFT agent. The resultant multiarm star block copolymer (H40-PNIPAM) exists as unimolecular micelles with H40 core, densely grafted PNIPAM shell. A combination laser light...

Poly(N-isopropylacrylamide) (PNIPAM)-based tetrafunctional atom transfer radical polymerization (ATRP) macroinitiator (1b) was synthesized via addition reaction of mono-amino-terminated PNIPAM (1a) with glycidol, followed by esterification excess 2-bromoisobutyryl bromide. Well-defined double hydrophilic miktoarm AB4 star copolymer, PNIPAM-b-(PDEA)4, then polymerizing 2-(diethylamino)ethyl methacrylate (DEA) ATRP in 2-propanol at 45 degrees C using 1b, where PDEA poly(2-(diethylamino)ethyl...

Abstract The formation of a novel drug‐delivery carrier for the controlled release plasmid DNA that comprises layer‐by‐layer polymer capsules subcompartmentalized with pH‐sensitive nanometer‐sized polymersomes is reported. amphiphilic diblock copolymer poly(oligoethylene glycol methacrylate)‐ block ‐poly(2‐(diisopropylamino)ethyl methacrylate) forms at physiological pH, but transitions to unimeric chains upon acidification cellular endocytic pH. These can thus an encapsulated payload in...

Two oppositely charged graft ionomers, P(MAA-co-AzPMA)-g-PNIPAM and P(QDMA-co-AzPMA)-g-PNIPAM, containing thermosensitive PNIPAM chains were successfully synthesized via a combination of atom transfer radical polymerization (ATRP) "click" reactions, where PAzPMA, PMAA, PNIPAM, PQDMA are poly(3-azidopropyl methacrylate), poly(methacrylic acid), poly(N-isopropylacrylamide), poly(2-(dimethylamino)ethyl methacrylate) (PDMA) fully quaternized with methyl iodide, respectively. In aqueous solution,...

Highly stable hybrid unimolecular micelles with thermosensitive poly(N-isopropylacrylamide) (PNIPAM) shells incorporated Ag nanoparticles were prepared in situ via a facile approach. Heating the micellar solutions leads to shrinkage of PNIPAM shell and allows for tuning relative spatial distances between neighboring nanoparticles. Because anchoring stabilization brush nanoparticles, distribution within is completely reversible heating/cooling cycles. The preparation procedures their...

Using a narrowly distributed poly($N$-isoporpylacrylamide) (PNIPAM) chain with degree of polymerization ($N$) 3100, randomly labeled pyrene, we have, for the first time, observed two-stage kinetics coil-to-globule transition. Two characteristic relaxation times, ${\ensuremath{\tau}}_{\mathrm{fast}}$ crumpling random coil ($\ensuremath{\sim}12\text{ }\text{ }\mathrm{ms}$) and ${\ensuremath{\tau}}_{\mathrm{slow}}$ collapsing crumpled to compact globule ($\ensuremath{\sim}270\text{...

The synthesis of cross-linker free layer-by-layer (LbL) capsules that solely utilize cellular pH variations as a trigger to specifically deconstruct and subsequently release cargo in cells is reported. These demonstrate retention water-soluble therapeutic molecules small 500 Da at extracellular pH. Triggered capsule degradation observed within 30 min cell uptake. As service our authors readers, this journal provides supporting information supplied by the authors. Such materials are peer...

The interactions between chemicals and DNA molecules provide effective regulation tools for dynamically controlling the self-assembly of higher-order nanostructures, which mostly rely on non-covalent π−π stacking, hydrogen-bonding electrostatic...

Tile‐based self‐assembly is a simple yet highly efficient bottom‐up nanofabrication strategy, which has been widely applied in many fields such as structural DNA nanotechnology. The of tile determined by not only the sequence design, but also existing nick tile, it would influence flexibility and symmetry tile. Herein, we systematically investigated impact on tile‐based assembly three‐dimensional (3D) polyhedra various conditions. A series concentrations, four different sticky ends, two...

Background: This study aims to analyze the vaccination status and factors influencing delayed among toddlers born hepatitis B surface antigen (HBsAg)-positive mothers. Methods: Data of HBsAg-positive mothers between 1 January 2021 31 December 2022 were provided by Suzhou Maternal Child Health Care Family Planning Service Center. The records obtained from Jiangsu Province Immunization Management Information System. Logistic regression analysis was used vaccination. Results: A total 4250...

We describe the first account of synthesis and intriguing micellization properties nonlinear double hydrophilic block copolymers (DHBCs) A2BA2 A4BA4 type. Atom transfer radical polymerization (ATRP) macroinitiators with two four initiating sites at both ends poly(propylene oxide) (PPO) chain were synthesized via reacting 2-hydroxyethyl acrylate glycidol commercially available diamine-terminated PPO, respectively, followed by esterification excess 2-bromoisobutyryl bromide or 2-bromopropionyl...

It is known that the zwitterionic diblock copolymer, poly(4-vinylbenzoic acid)-b-poly(N-(morpholino)ethyl methacrylate) (VBA-b-MEMA), exhibits interesting "schizophrenic" micellization behavior (see: Liu, S.; Armes, S. P. Langmuir 2003, 19, 4432−4438). The kinetics of pH-induced formation and dissociation VBA−core micelles, salt-induced dilution-induced MEMA−core micelles at pH 10, micellar inversion between VBA− in presence 0.8 M Na2SO4 were studied detail using stopped-flow apparatus...

Gold nanoparticles were covalently conjugated onto the surface of thiol-functionalized thermosensitive unimolecular micelles to fabricate novel satellite-like nanostructures. The resultant nanostructures consist gold distributed across isolated micelles. Because covalent linkage between thiol groups and nanoparticles, this type hybrid nanostructure was highly stable. Most importantly, micelle templates can reversibly swell shrink in response external temperatures. This made it possible...

Abstract Nano‐/micrometer‐scaled films and capsules made of low‐fouling materials such as poly(ethylene glycol) (PEG) are interest for drug delivery tissue engineering applications. Herein, the assembly degradation low‐fouling, alkyne‐functionalized PEG (PEG Alk ) multilayer capsules, which prepared by combining layer‐by‐layer (LbL) click chemistry, reported. A nonlinear, temperature‐responsive is synthesized, then used to form hydrogen‐bonded multilayers with poly(methacrylic acid) (PMA) at...

We report a versatile approach for controlling the intracellular degradation of polymer capsules by tailoring degree cross-linking in capsules. Poly(2-diisopropylaminoethyl methacrylate) were assembled layer-by-layer technique and covalently stabilized with redox-responsive bisazide cross-linker using click chemistry. The cross-linking, determined radiation scintillation counting, was tuned from 65% to 98% adjusting amount used stabilize films. Transmission electron microscopy fluorescence...

Proton transfer polymerization between thiol and epoxide groups is shown to be an adaptable utilitarian method for the synthesis of hydrogels. For instance, catalyst can organic or inorganic, medium pure water, buffer solutions, solvents. The gelation mechanism triggered at ambient conditions, a physiological temperature 37 °C, through using light as external stimulus. photochemical methods both allow nanoimprint lithography produce freestanding patterned thick films. required thiol-...