A5060721659- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Nicotinic Acetylcholine Receptors Study
- Carcinogens and Genotoxicity Assessment
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Cholinesterase and Neurodegenerative Diseases
- Tryptophan and brain disorders
- Mast cells and histamine
- Neuroinflammation and Neurodegeneration Mechanisms
- Autism Spectrum Disorder Research
- Parkinson's Disease Mechanisms and Treatments
- Molecular Sensors and Ion Detection
- Acute Ischemic Stroke Management
- Pharmacological Receptor Mechanisms and Effects
- Neurological disorders and treatments
- Olfactory and Sensory Function Studies
- Adipose Tissue and Metabolism
- CRISPR and Genetic Engineering
- DNA and Nucleic Acid Chemistry
- Synthesis and Biological Evaluation
- Ion channel regulation and function
- Bioactive Compounds and Antitumor Agents
Semmelweis University
2006-2024
Gedeon Richter (Hungary)
2015-2024
Egis Pharmaceuticals (Hungary)
2005-2022
Institute of Cognitive Neuroscience and Psychology
2017
Egis (France)
1998-2009
HUN-REN Institute of Experimental Medicine
1988-2009
Servier (France)
2008
University of California, San Francisco
1991-2005
Neurological Surgery
1992-1996
We have examined DNA adduct formation and cytotoxicity in HL-60 cells treated with either hydroquinone (HQ) or p-benzoquinone (p-BQ Treatment of HQ p-BQ produced the same adduct. The level varied from 0.05 to 10 adducts per 107 nucleotides as a function treatment time concentration for both compounds. To achieve required higher concentrations longer times compared p-BQ. was also more cytotoxic than HQ. Reaction calf thymus p-BQ/HQ mixture five detected by 32P-postlabeling. Two isomers...
A series of potent 5-hydroxytryptamine 7 (5-HT 7) ligands has been synthesized that contain a 1,3-dihydro-2 H-indol-2-one (oxindole) skeleton. The binding these compounds to the 5-HT and 1A receptors was measured. Despite structural similarity two serotonin receptor subtypes, several derivatives exhibited high selectivity receptor. According structure-activity relationship observations, unsubstituted at oxindole nitrogen atom containing tetramethylene spacer between skeleton basic are most...
The aim of the present study was to establish an in vitro Kleefstra syndrome (KS) disease model using human induced pluripotent stem cell (hiPSC) technology. Previously, autism spectrum disorder (ASD) patient with (KS-ASD) carrying a deleterious premature termination codon mutation EHMT1 gene identified. Patient specific hiPSCs generated from peripheral blood mononuclear cells KS-ASD were differentiated into post-mitotic cortical neurons. Lower levels mRNA as well protein expression...
Using P1 nuclease enhanced 32P postlabeling, we investigated DNA adduct formation in HL-60 promyelocytic leukemia cells treated with the benzene metabolites hydroquinone, catechol, and 1,2,4-benzenetriol. Comparison of slopes dose-response curves showed that hydroquinone was 7-9 times more effective than 1,2,4,-benzenetriol catechol at inducing adducts. a good correlation between cytotoxicity. Similar comparisons suggest cellular processes addition to contributed In combination either or...
Journal Article Detection of dopamine DNA adducts: potential role in Parkinson's disease Get access György Lévay, Lévay 1Brain Tumor Research Center the Department Neurological SurgerySan Francisco, CA 94143, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar William J. Bodell 3 USA2Department Radiation Oncology, School Medicine, University CaliforniaSan 3To whom correspondence should be addressed at: Surgery, c/o The Editorial Office, 1360 Ninth Avenue,...
We have investigated the formation of DNA adducts in bone marrow and white blood cells male B6C3F1 mice treated with benzene using P1-enhanced 32P-postlabeling. No were detected controls or various doses once a day. After twice-daily treatment for 1 to 7 days benzene, 440 mg/kg, one major (no. 1) up two minor both cells. The relative adduct levels these ranged from 0.06 1.46 x 10(-7). significant correlation (r2 = 0.95) between was observed. 7-day mg/kg twice day, number per femur decreased...
While cerebellar alterations may play a crucial role in the development of core autism spectrum disorder (ASD) symptoms, their pathophysiology on function cerebrocerebellar circuit loops is largely unknown. We combined multimodal MRI (9.4 T) brain assessment prenatal rat valproate (VPA) model and correlated immunohistological analysis Purkinje cell number to address this question. hypothesized that suitable functional (fMRI) paradigm might show some altered activity related disrupted...