A5060217047- Neuroscience and Neuropharmacology Research
- Adenosine and Purinergic Signaling
- Sleep and Wakefulness Research
- Stress Responses and Cortisol
- Photoreceptor and optogenetics research
- Epilepsy research and treatment
- Tryptophan and brain disorders
- Neural dynamics and brain function
- Neuroinflammation and Neurodegeneration Mechanisms
- Complement system in diseases
- Genetics and Neurodevelopmental Disorders
- Biochemical effects in animals
- Alzheimer's disease research and treatments
- Ion channel regulation and function
- Protease and Inhibitor Mechanisms
- S100 Proteins and Annexins
- Neuroendocrine regulation and behavior
- Blood Coagulation and Thrombosis Mechanisms
- Neuroscience of respiration and sleep
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Pharmacological Effects and Toxicity Studies
- Bipolar Disorder and Treatment
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
Eötvös Loránd University
2015-2024
Hungarian Academy of Sciences
2000-2017
HUN-REN Research Centre for Natural Sciences
2017
Institute of Neurobiology
2010-2012
University of Sopron
2011
University of California, San Diego
1994
Several aspects of perception, particularly those pertaining to vision, are closely linked the occipital alpha (α) rhythm. However, how α rhythm relates activity neurons that convey primary visual information is unknown. Here we show in behaving cats, thalamocortical lateral geniculate nucleus (LGN) operate a conventional relay-mode form two groups where cumulative firing subject cyclic suppression centered on negative peak one group and positive other. This leads an effective temporal...
Preeclampsia is a disease of the mother, fetus and placenta, gaps in our understanding complex interactions among their pathways withheld successful treatment prevention. The placenta has key role pathogenesis terminal pathway characterized by exaggerated maternal systemic inflammation, generalized endothelial damage, hypertension proteinuria. This sine qua non preeclampsia may be triggered distinct underlying mechanisms that occur at early stages pregnancy induce different phenotypes. To...
Significance Synaptic pruning is dominant in early ontogenesis when a large number of unnecessary synapses are eliminated, and it maintains synaptic plasticity the mature healthy brain, e.g., memory processes. Its malfunction involved degenerative diseases such as Alzheimer’s disease. C1q, member immune complement system, plays central role selective by microglial phagocytosis. Understanding molecular aspects complement-mediated synapse elimination high importance for developing effective...
Bradykinin (BK), generated from high-molecular-weight kininogen (HK) is the major mediator of swelling attacks in hereditary angioedema (HAE), a disease associated with C1-inhibitor deficiency. Plasma kallikrein, activated by factor XIIa, responsible for most HK cleavage. However other proteases, which activate during episodes angioedema, might also contribute to BK production. The lectin pathway complement system activates after infection and oxidative stress on endothelial cells generating...
Glutamate (Glu) and gamma-aminobutyric acid (GABA) transporters play important roles in regulating neuronal activity. Glu is removed from the extracellular space dominantly by glial transporters. In contrast, GABA mainly taken up neurons. However, transporter subtypes share their localization with expression confined to same subpopulation of astrocytes, raising possibility cooperation between transport processes.Here we used diverse biological models both vitro vivo explore interplay these...
The lectin pathway is an antibody-independent activation route of the complement system. It provides immediate defense against pathogens and altered self-cells, but it also causes severe tissue damage after stroke, heart attack, other ischemia reperfusion injuries. triggered by target binding pattern recognition molecules leading to zymogen mannan-binding lectin-associated serine proteases (MASPs). MASP-2 considered as autonomous pathway-activator, while MASP-1 auxiliary component. We...
Abstract Synaptic functional disturbances with concomitant synapse loss represent central pathological hallmarks of Alzheimer’s disease. Excessive accumulation cytotoxic amyloid oligomers is widely recognized as a key event that underlies neurodegeneration. Certain complement components are crucial instruments widespread because they can tag synapses impairments leading to their engulfment by microglia. However, an exact understanding the affected synaptic functions predispose...
The complement system, an essential part of the innate immune can be activated through three distinct routes: classical, alternative, and lectin pathways. contribution individual activation pathways to different biological processes assessed by using pathway-selective inhibitors. In this paper, we report pathway-specific short peptide inhibitors developed phage display against mannose-binding lectin-associated serine proteases (MASPs), MASP-1 MASP-2. On basis selected sequences, two 14-mer...
Probing molecular brain mechanisms related to increased suicide risk is an important issue in biological psychiatry research. Gene expression studies on post mortem brains indicate extensive changes prior a successful attempt; however, proteomic are scarce. Thus, we performed DIGE analysis of tissue samples from the prefrontal cortex and amygdala victims identify protein biomarker candidates suicide. Among our matched spots found 46 16 significant differences amygdala, respectively; by using...
S100A4 is a member of the S100 family calcium-binding proteins that directly involved in tumor metastasis. It binds to nonmuscle myosin IIA (NMIIA) tail near assembly competence domain (ACD) promoting filament disassembly, which could be associated with increasing metastatic potential cells. Here, we investigate mechanism S100A4–NMIIA interaction based on binding studies and crystal structure complex 45-residue-long heavy chain fragment. Interestingly, also find as strongly homologous...
Elements of the immune system particularly that innate immunity, play important roles beyond their traditional tasks in host defense, including manifold nervous system. Complement-mediated synaptic pruning is essential developing and healthy functioning brain becomes aberrant neurodegenerative disorders. C1q, component classical complement pathway, plays a central role tagging synapses for elimination; however, underlying molecular mechanisms interaction partners are mostly unknown. Neuronal...
Abstract Synaptosomes are frequently used research objects in neurobiology studies focusing on synaptic transmission as they mimic several aspects of the physiological functions. They contain whole apparatus for neurotransmission, presynaptic nerve ending with vesicles, mitochondria and often a segment postsynaptic membrane along density is attached to its outer surface. As being artificial functional organelles, synaptosomes viable hours, retain their activity, potential, capable store,...
The human placenta maintains pregnancy and supports the developing fetus by providing nutrition, gas-waste exchange, hormonal regulation, an immunological barrier from maternal immune system. villous syncytiotrophoblast carries most of these functions provides interface between fetal circulatory systems. is generated biochemical morphological differentiation underlying cytotrophoblast progenitor cells. dysfunction trophoblast development implicated in placenta-mediated complications. Herein,...