A5057987538- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Cancer, Lipids, and Metabolism
- Diet and metabolism studies
- Connexins and lens biology
Pontificia Universidad Católica de Chile
2017-2021
Abstract Clinical localization of primary tumors and sites metastasis by PET is based on the enhanced cellular uptake 2-deoxy-2-[18F]-fluoro-D-glucose (FDG). In prostate cancer, however, PET-FDG imaging has shown limited clinical applicability, suggesting that cancer cells may utilize hexoses other than glucose, such as fructose, preferred energy source. Our previous studies suggested overexpress fructose transporters, but not glucose compared with benign cells. Here, we focused validating...
Abstract The elevated level of glucose uptake and metabolism in cancers is the basis for clinical localization primary sites metastasis by positron emission tomography (PET scanning), based on enhanced cellular 2-deoxy-2-[18F]-fluoro-D-glucose (FDG). In prostate cancer (CaP), however, FDG-PET imaging has shown limited applicability. This striking difference suggests that CaP cells utilize hexoses other than glucose, such as fructose, principal energy source. purpose this study was to...
Abstract Prostate cancer (CaP) is the most commonly diagnosed and second leading cause of deaths among males in United States. Androgen deprivation therapy (ADT) standard treatment for advanced or metastatic CaP. However, during ADT, CaP progresses from an androgen-sensitive (AS-CaP) to a more aggressive, eventually lethal, castration-resistant (CRPC) phenotype. There evidence suggest that prostate tumor mass under tight control endothelial microvasculature due increase angiogenesis by...
Introduction PET-scanning can detect primary tumours relaying on their high glucose uptake ability through overexpression of the transporter Glut-1. However, this method has shown limited clinical applicability for prostate cancer (PCa) diagnosis, suggesting that PCa cells do not use as its source energy. Preliminary data from our laboratory fructose Glut-5 in cell lines and specimens PCa, which suggest could play an important role biology. Material methods We analysed effect aggressiveness...
Introduction The clinical localization of primary cancers and sites metastasis by positron emission tomography (PET) is based on the enhanced cellular uptake 2-deoxy-2-[ 18 F]-fluoro-d-glucose (FDG). In prostate cancer (CaP), however, FDG-PET imaging has shown limited applicability. This striking difference suggests that CaP cells utilise hexoses other than glucose, such as fructose, principal energy source. purpose this study was to determine whether or not fructose a/the source for cells....