A5050428325- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Cutaneous Melanoma Detection and Management
- Silicon Carbide Semiconductor Technologies
- Cancer Immunotherapy and Biomarkers
- Biosimilars and Bioanalytical Methods
- Immunotherapy and Immune Responses
- Integrated Circuits and Semiconductor Failure Analysis
- Chronic Myeloid Leukemia Treatments
- COVID-19 and healthcare impacts
- Immune Cell Function and Interaction
- Venous Thromboembolism Diagnosis and Management
- Urologic and reproductive health conditions
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Melanoma and MAPK Pathways
- Gastroesophageal reflux and treatments
- Blood disorders and treatments
- Quality and Supply Management
- Porphyrin Metabolism and Disorders
- Neutropenia and Cancer Infections
- Virus-based gene therapy research
- Testicular diseases and treatments
- COVID-19 Clinical Research Studies
Brigham and Women's Hospital
2018-2022
Dana-Farber Cancer Institute
2018-2022
Harvard University
2020-2022
University of Washington
2017-2020
Fred Hutch Cancer Center
2017-2020
Dana-Farber Brigham Cancer Center
2018-2020
Seattle Cancer Care Alliance
2018-2020
Cancer Research Center
2020
Mercy St. Vincent Medical Center
2020
University of Washington Medical Center
2017-2019
Axicabtagene ciloleucel (axi-cel) was approved by the Food and Drug Administration for relapsed aggressive B-cell non-Hodgkin lymphoma in part on basis of durable remission rates approximately 40% a clinical trial population. Whether this efficacy, toxicity, would be consistent postcommercial setting, with relaxed eligibility criteria bridging therapy, is unknown. This study describes efficacy safety correlates outcomes setting.
Allogeneic hematopoietic cell transplantation (alloHCT) can potentially salvage large B-cell lymphoma (LBCL) patients experiencing treatment failure after chimeric antigen receptor T-cell therapy (CAR T). Nonetheless, data on the efficacy and toxicities of alloHCT receipt CAR T are limited. We report a multicenter retrospective study assessing safety, toxicities, outcomes in LBCL following failure. Eighty-eight with relapsed, refractory received an anti-CD19 The median number lines between...
Some forms of pharmacotherapy are shown to increase the risk community-acquired pneumonia (CAP). The purpose this study is investigate whether with proton pump inhibitors (PPI), inhaled corticosteroids, and atypical antipsychotics was associated increased for CAP in hospitalized older adults adjustment known factors (such as smoking status serum albumin levels).A retrospective case-control aged 65 years or at a rural community hospital during 2004 2006 conducted. Cases (N = 194) were those...
Abstract The novel coronavirus severe acute respiratory syndrome 2 (SARS-CoV-2), identified in late 2019 as the causative agent of COVID-19, was declared a pandemic by World Health Organization on 11 March 2020. Widespread community transmission United States triggered nationwide shutdown, raising major challenges for administration hematopoietic stem cell transplant (HSCT) and chimeric antigen receptor (CAR)-T therapies, leading many centers to delay or cancel operations. We sought assess...
Abstract Concurrent hemolysis in patients with vitamin B12 deficiency is a well-recognized phenomenon and has been attributed to intramedullary destruction of erythrocytes (ineffective erythropoiesis). Recent studies revealed that homocysteine increased the risk vitro there high frequency (30%) asymptomatic homozygous methylene tetrahydrofolate reductase (MTHFR) C677T mutation, known cause hyperhomocysteinemia. Here we report three MTHFR mutations presenting hemolytic anemia severely...
Aim: Acute myeloid leukemia (AML) is an aggressive hematopoietic clonal disorder characterized by the increased blasts and poor survival outcome, which mainly driven cytogenetic molecular abnormalities. Here, we investigated prognostic impact of other demographic parameters on outcomes in AML patients. Method: We reviewed Surveillance, Epidemiology, End Result (SEER) database to collect information, including age, diagnosis, gender, race, geographic region patients with non-acute...
Indian industries have gone for ISO certification in a big way since the beginning of 1990. This independent survey was undertaken to assimilate experiences companies gathered path certification, its impact on their business, opinion about auditing firms and hurdles faced certification. is largest most wide-ranging kind be conducted this country. It covers well over 1200 9000-certified organizations all sizes industry sectors registered by different bodies. Analysis data revealed that 9000...
Proton pump inhibitor (PPI) may suppress adrenal cortical steroid synthesis and release, thereby leading to electrolyte disturbances. Both hyponatremia hyperkalemia in the setting of PPI therapy have been documented case reports. The objective this study was examine association between serum potassium (K(+)) level use.A retrospective data analysis hospitalized adults aged > or = 65 years during 2006, including users (N 257) non-users 388), conducted. Multiple linear logistic regression...
Constipation is highly prevalent in older adults and may be associated with greater frequency of acute exacerbation chronic obstructive pulmonary disease (AECOPD). We investigated the prevalence lower defecation (DF) risk factors (including AECOPD) DF among hospitalized elderly patients.We conducted a retrospective case-control study community hospital Southeast Ohio. Adults aged 65 years or admitted during 2004 2006 were reviewed (N = 1288). Patients excluded 212) if their length stay was...
The very premises on which ISO 9000 certification was marketed seem to have fallen by the wayside during past 8 years. Thousands of companies across India and also world embraced route. After a few years togetherness with 9001/9002 system, companies' chief executive officers are disillusioned. Apparently, anticipated result, 'quality improvement', has not materialized. Instead, they see only costs being accrued, documents records piling up. In some extreme cases, parallel system even...
BackgroundIn relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) patients (pts) who had previously failed ibrutinib, we observed durable responses after CD19 chimeric antigen receptor-modified T-cell immunotherapy (Turtle CJ et al, JCO, 2017; NCT01865617). The combination of CAR-T cells with ibrutinib might improve response and decrease toxicity.ObjectivesTo evaluate the efficacy toxicity cell alone or in for R/R CLL.MethodsOur phase 1/2 study established a preferred regimen CLL pts...
Summary.— The effect of the oral contraceptive on previously asymptomatic variegate porphyria is described. importance presence X‐porphyrins in discussed.