A5032471367- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Monoclonal and Polyclonal Antibodies Research
- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Complement system in diseases
- Chronic Lymphocytic Leukemia Research
- Ubiquitin and proteasome pathways
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Clinical Laboratory Practices and Quality Control
- Pesticide Exposure and Toxicity
- Cancer Treatment and Pharmacology
- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Cancer therapeutics and mechanisms
- Climate Change and Health Impacts
- Peptidase Inhibition and Analysis
- Esophageal and GI Pathology
- Viral Infections and Immunology Research
- Colorectal Cancer Surgical Treatments
- Glycosylation and Glycoproteins Research
- Gastric Cancer Management and Outcomes
- Fungal Plant Pathogen Control
- Neonatal and Maternal Infections
- Neutropenia and Cancer Infections
Memorial Sloan Kettering Cancer Center
2015-2024
Mayo Clinic
2011
Mayo Clinic in Arizona
2010
Johns Hopkins University
2000-2009
Murata (Finland)
2008
Johns Hopkins Medicine
2000-2006
Associated Press
2004
University of Baltimore
2000
Summary Background The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was developed using both CKD and non-CKD patients to potentially replace the Modification of Diet in Renal (MDRD) that derived with only patients. objective our study compare accuracy MDRD CKD-EPI equations for estimating GFR a large group having measurements diverse clinical indications. Design, setting, participants, A cross-sectional conducted who underwent renal function assessment purposes by...
Abstract We studied the prevalence of monoclonal gammopathy undetermined significance (MGUS) in younger individuals, age 10–49 years, using samples from National Health and Nutritional Examination Survey (NHANES) III. NHANES rates were standardized to 2000 US total population. Among 12 372 individuals (4073 blacks, 4146 Mexican-Americans, 3595 whites, 558 others), MGUS was identified 63 persons (0.34%, 95% CI 0.23–0.50). The significantly higher blacks (0.88%, 0.62–1.26) compared with whites...
Recently, the benefit of adding daratumumab to proteasome inhibitor-based, 3-drug combination bortezomib, lenalidomide, and dexamethasone for patients with newly diagnosed multiple myeloma who underwent high-dose melphalan chemotherapy autologous hemopoietic cell transplant was assessed. Here, we examine addition second-generation carfilzomib, dexamethasone.To assess safety effectiveness carfilzomib-lenalidomide-dexamethasone-daratumumab therapy myeloma, in absence transplant.Clinical...
Abstract B-cell maturation antigen (BCMA)–targeting therapeutics have dramatically improved outcomes in relapsed/refractory multiple myeloma (RRMM). However, whether the mechanisms of resistance between these therapies are shared and how identification such before therapy initiation could refine clinical decision-making remains undefined. We analyzed for 72 RRMM patients treated with teclistamab, a CD3 × BCMA bispecific antibody, 42% (30/72) whom had prior BCMA-directed exposure. Malignant...
Teclistamab, a B-cell maturation antigen (BCMA)- and CD3-targeting bispecific antibody, is an effective novel treatment for relapsed/refractory multiple myeloma (R/RMM), but efficacy in patients exposed to BCMA-directed therapies mechanisms of resistance have yet be fully delineated. We conducted real-world retrospective study commercial teclistamab, capturing both clinical outcomes immune correlates response cohort (n = 52) with advanced R/RMM. Teclistamab was highly overall rate (ORR) 64%,...
Platelets recruit leukocytes and mediate interactions between endothelial cells. Most studies examining this important platelet immune function have focused on the development of atherosclerosis, but similar mechanisms may contribute to acute chronic vascular lesions in transplants. been described as markers transplant rejection, little investigation has critically examined a role for platelets vasculopathy and, particular, alloantibody-mediated rejection. We now demonstrate using skin model...
Background. Antibody-mediated rejection is characterized by macrophage margination against vascular endothelium. The potential interactions triggered antibodies between endothelial cells (EC) and macrophages have not been examined thoroughly in transplants. We used vivo vitro models of antibody-mediated rejection. Methods. Passive transfer monoclonal alloantibodies (Allo-mAbs) to donor major histocompatibility complex-class I antigens was restore acute B10.A (H-2a) hearts C57BL/6 (H-2b)...
Background: Farmers have a higher incidence of multiple myeloma, and there is suggestive evidence an elevated prevalence its precursor, monoclonal gammopathy undetermined significance (MGUS), relative to the general population. Pesticide exposures are suspected play role; however, biologic plausibility for associations with myeloma remains unclear. Objectives: Our objectives were examine MGUS evaluate wide range pesticides in large sample farmers. Methods: We obtained sera assessed among...
An explosion of knowledge and technology is revolutionizing medicine patient care. Novel testing must be brought to the clinic with safety accuracy, but also in a timely cost-effective manner, so that patients can benefit laboratories offer consistent current guidelines. Under oversight provided by Clinical Laboratory Improvement Amendments, have been able develop optimize laboratory procedures for use in-house. Quality improvement programs, interlaboratory comparisons, ability adjust assays...
A 53-year-old woman presented to the orthopedic department with severe diffuse muscular and bone pain. An x-ray of her right upper extremity revealed a lytic destructive lesion in humerus. Computed tomography scans showed multiple lesions spine pelvis, biopsy confirmed presence 70% plasma cells, which were κ light chain restricted. The patient was referred hematologist. Although no monoclonal protein detected serum by electrophoresis or immunofixation (IFE),1 free (FLC) increased at 47.2...
Many patients on the waiting list for transplants are sensitized from previous blood transfusions, pregnancy, or transplants. We investigated role of complement in acute and chronic pathology hearts transplanted to rats.Blood was transfused allogeneic PVG.R8 rats control isogeneic PVG.1U C6-sufficient -deficient rats. Three weeks later were donors low-dose cyclosporin A initiated.Allogeneic but not transfusion elicited strong immunoglobulin (Ig) M, IgG1 IgG2b alloantibody responses....
Posttransplant lymphoproliferative disorder (PTLD) is a neoplastic complication of transplantation, with early cases largely due to immunosuppression and primary Epstein-Barr virus infection. Etiology may differ for later-onset cases, but the contributions immunosuppression, immune reactivity donor organ, chronic B cell activation are uncertain.We conducted case-control study late-onset PTLD (diagnosed >1 year posttransplant) in cohort liver recipients. We assessed serum samples (obtained >6...
Background. C4d is a useful marker of antibody-mediated rejection in cardiac and renal transplants, but clinical studies examining correlations between circulating alloantibodies, deposition, lung transplants have yielded conflicting results. Methods. We studied alloantibody levels deposition two rat models transplantation: Brown Norway (BN) to Wistar-Kyoto (WKY) PVG.R8 PVG.1U allografts. The availability C6 deficient (C6−) sufficient (C6+) PVG 1U rats allowed evaluation the effects terminal...
Serum immunofixation (IF) is a common laboratory test used to diagnose and monitor patients with monoclonal gammopathies. Similarly, immunotyping (IT) by capillary electrophoresis can confirm the presence of protein (M-protein) determine its isotype. The goal this study was compare ability IT IF detect M-proteins.IT results for 1000 waste clinical serum samples were obtained. All interpreted blindly reviewers who experienced in each technique. Results compared band. also patient history if...