Donald P. Fraser

ORCID: 0000-0002-5951-6365
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Light effects on plants
  • Greenhouse Technology and Climate Control
  • Biosensors and Analytical Detection
  • SARS-CoV-2 detection and testing
  • Plant Molecular Biology Research
  • Genetic diversity and population structure
  • SARS-CoV-2 and COVID-19 Research
  • Genomics and Phylogenetic Studies
  • Molecular Biology Techniques and Applications
  • Chromosomal and Genetic Variations
  • Photosynthetic Processes and Mechanisms
  • Plant Gene Expression Analysis
  • Circadian rhythm and melatonin
  • Spaceflight effects on biology

Royal Botanic Gardens, Kew
2021-2022

University of Bristol
2016-2021

University of Warwick Science Park
2020

Coventry (United Kingdom)
2020

Small increases in ambient temperature can elicit striking effects on plant architecture, collectively termed thermomorphogenesis [1Quint M. Delker C. Franklin K.A. Wigge P.A. Halliday K.J. van Zanten Molecular and genetic control of thermomorphogenesis.Nat. Plants. 2016; 2: 15190Crossref PubMed Scopus (304) Google Scholar]. In Arabidopsis thaliana, these include marked stem elongation leaf elevation, responses that have been predicted to enhance cooling [2Gray W.M. Östin A. Sandberg G....

10.1016/j.cub.2016.11.004 article EN cc-by Current Biology 2016-12-15

High temperature promotes guard cell expansion, which opens stomatal pores to facilitate leaf cooling. How the high-temperature signal is perceived and transmitted regulate aperture is, however, unknown. Here, we used a reverse-genetics approach understand high temperature-mediated opening in Arabidopsis (

10.1104/pp.19.01528 article EN cc-by PLANT PHYSIOLOGY 2020-01-16

Genome size varies 2400-fold across plants, influencing their evolution through changes in cell and division rates which impact plants' environmental stress tolerance. Repetitive element expansion explains much genome diversity, the processes structuring repeat 'communities' are analogous to those ecological communities. However, stressors influence community dynamics has not yet been examined from an perspective. We measured leveraged climatic data for 91% of genera within ecologically...

10.1111/nph.18323 article EN cc-by New Phytologist 2022-06-19

Despite controlling a diverse array of regulatory processes in plants, UV-B wavelengths (280-315 nm) are attenuated by common greenhouse materials such as glass and polycarbonate therefore depleted many commercial growing environments. In this study, we analysed the architecture, pigment accumulation antioxidant capacity coriander (Coriandrum sativum, also known cilantro) plants grown with without supplementary (1.5 µmol m-2 s-1). We demonstrate that limits stem elongation responses to...

10.1038/s41598-017-18073-8 article EN cc-by Scientific Reports 2017-12-13

Shade-avoiding plants can detect the presence of neighboring vegetation and evoke escape responses before canopy cover limits photosynthesis. Rapid stem elongation facilitates light foraging enables to overtop competitors. A major regulator this response is phytochrome B photoreceptor, which becomes inactivated in environments with a low ratio red far-red (low R:FR), characteristic vegetational shade. Although shade avoidance provide competitive advantage fast-growing stands, excessive be...

10.1073/pnas.2108176118 article EN Proceedings of the National Academy of Sciences 2021-06-29

Shortage of reagents and consumables required for the extraction molecular detection SARS-CoV-2 RNA in respiratory samples has led many laboratories to investigate alternative approaches sample preparation. Many groups recently presented results using heat processing method prior RT-qPCR as an economical enabling extremely fast streamlining processes at virtually no cost. Here, we present our this highlight some major pitfalls that diagnostics should be aware before proceeding with...

10.1371/journal.pone.0243266 article EN cc-by PLoS ONE 2020-12-07

Polymerase chain reaction (PCR)-based assays were widely deployed during the SARS-CoV-2 pandemic for population-scale testing. High-throughput molecular diagnostic laboratories required a high degree of process automation to cope with huge testing demands, fast turnaround times, and quality requirements. However, developers optimizers often neglected critical step preparing PCR Master Mix. The construction Mix depends on operator skill manual pipetting reagents. Manual procedures introduce...

10.1016/j.slast.2024.100195 article EN cc-by SLAS TECHNOLOGY 2024-09-28

Abstract In late 2021, the Omicron SARS-CoV-2 variant spread rapidly worldwide. To track its emergence, and continued evolution of while giving actionable epidemiological data that informs public health policy, we developed a high-throughput, automated, genotyping workflow pairs flexible liquid handling with re-configurable LIMS system. This facilitated real-time monitoring BA.4 BA.5, by time retirement, system was responsible for typing c . 400,000 samples. When combined population-scale...

10.1101/2023.06.03.23289684 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2023-06-05

Summary Genome size varies 2,400-fold across plants, influencing their evolution through changes in cell and division rates which impact plants’ environmental stress tolerance. Repetitive element expansion explains much genome diversity, the processes structuring repeat ‘communities’ are analogous to those ecological communities. However, stressors influence community dynamics has not yet been examined from an perspective. We measured leveraged climatic data for 91% of genera within...

10.1101/2021.11.04.467295 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2021-11-08

Abstract Polymerase Chain Reaction (PCR)-based assays were widely deployed during the SARS-CoV-2 pandemic for population-scale testing. High-throughput molecular diagnostic labora-tories required a high degree of process automation to cope with huge testing demand, fast turn-around times and quality requirements. However, critical step preparing PCR MasterMix has often been neglected by developers optimisers, is largely dependent upon operator skill manual pipetting reagents construct...

10.1101/2023.10.04.23296537 preprint EN cc-by-nd medRxiv (Cold Spring Harbor Laboratory) 2023-10-05
Coming Soon ...